Metabolic origin of insulin resistance in obesity with and without Type 2 (non-insulin-dependent) diabetes mellitus View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1993-12

AUTHORS

J. P. Felber, E. Haesler, E. Jéquier

ABSTRACT

A metabolic hypothesis is presented for insulin resistance in obesity, in the presence or absence of Type 2 (non-insulin-dependent) diabetes mellitus. It is based on physiological mechanisms including a series of negative feed-back mechanisms, with the inhibition of the function of the glycogen cycle in skeletal muscle as a consequence of decreased glucose utilization resulting from increased lipid oxidation in the obese. It considers the inhibition of glycogen synthase activity together with inhibition of glucose storage and impaired glucose tolerance. The prolonged duration of increased lipid oxidation, considered as the initial cause, may lead to Type 2 diabetes. This hypothesis is compatible with others based on the inhibition of insulin receptor kinase and of glucose transporter activities. More... »

PAGES

1221-1229

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00400798

DOI

http://dx.doi.org/10.1007/bf00400798

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1039817823

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/8307248


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