Incidence of macrovascular disease in diabetes mellitus: the London cohort of the WHO Multinational Study of Vascular Disease in Diabetics View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1991-08

AUTHORS

N. J. Morrish, L. K. Stevens, J. H. Fuller, H. Keen, R. J. Jarrett

ABSTRACT

We report on the incidence of new macrovascular disease among the 497 members of the London Cohort of the WHO Multinational Study of Vascular Disease in Diabetics (aged 35–54 years at recruitment) over a mean 8.33 year follow-up period. Overall at the end of the follow-up period the prevalence of macrovascular disease in the cohort was 45%; 43% of the subjects showed evidence of ischaemic heart disease, 4.5% of cerebrovascular disease and 4.2% of peripheral vascular disease. The incidence rates for new disease in those subjects who were free at baseline expressed per 1000 patient years of follow-up were: ischaemic ECG abnormality 23.6 (patients with insulin-dependent diabetes 19.8, patients with non-insulin-dependent diabetes 28.1), myocardial infarction 17.6 (patients with insulin-dependent diabetes 16.5, patients with non-insulin-dependent diabetes 18.8), all ichaemic heart disease 31.7 (patients with insulin-dependent diabetes 30.3, patients with non-insulin-dependent diabetes 33.4), cerebrovascular disease 5.9 and peripheral vascular disease 5.2. Incidence rates were generally similar among men and women except for myocardial infarction in patients with non-insulin-dependent diabetes where men had a significantly higher incidence rate. Macrovascular disease is a major problem in patients with diabetes and in this age group is mainly manifested as ischaemic heart disease. More... »

PAGES

584-589

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00400278

DOI

http://dx.doi.org/10.1007/bf00400278

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1026579380

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/1936662


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