Islet amyloid polypeptide: demonstration of mRNA in human pancreatic islets by in situ hybridization in islets with and without amyloid ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1993-04

AUTHORS

G. T. Westermark, L. Christmanson, G. Terenghi, J. Permerth, C. Betsholtz, J. Larsson, J. M. Polak, P. Westermark

ABSTRACT

Islet amyloid polypeptide which is normally coexpressed with insulin in beta cells, forms amyloid deposits especially in islets of Type 2 (non-insulin-dependent) diabetic subjects. Occurrence of islet amyloid is paradoxically associated with loss of islet amyloid polypeptide immunoreactivity in beta cells. The present study was undertaken to examine whether the islet amyloid polypeptide gene is expressed in islets with decreased islet amyloid polypeptide immunoreactivity. Pancreatic tissue from 14 patients, 7 with Type 2 diabetes and 7 non-diabetic, were obtained at autopsy or surgery and studied for islet amyloid polypeptide expression by in situ hybridization and for presence of insulin and islet amyloid polypeptide by immunohistochemistry. Six of the specimens from the diabetic and three of those from the non-diabetic patients had varying degrees of islet amyloid polypeptide-derived islet amyloid. Amyloid deposits were associated with decreased numbers of beta cells with islet amyloid polypeptide immunoreactivity despite an apparent normal frequency of insulin-containing cells. This discrepancy might reflect an alteration in islet amyloid polypeptide production or processing at a transcriptional or post-transcriptional level. In contrast to the varying immunohistochemical patterns, islets of all categories showed strong labelling using an islet amyloid polypeptide probe for in situ hybridization. It is concluded that islet amyloid polypeptide production is not altered at the transcriptional level. The following possibilities remain: (1) islet amyloid polypeptide production may be altered at a post-transcriptional level or (2) that islet amyloid polypeptide production is normal but the reduced immunoreactivity of the cells reflects a reduced storage of IAPP in secretory granules. We favour the second possibility since islet amyloid deposition is incompatible with reduced islet amyloid polypeptide synthesis. More... »

PAGES

323-328

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00400235

DOI

http://dx.doi.org/10.1007/bf00400235

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1020885656

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/8477877


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged, 80 and over", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Amyloid", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Diabetes Mellitus, Type 2", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunohistochemistry", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "In Situ Hybridization", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Insulin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Islet Amyloid Polypeptide", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Islets of Langerhans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA, Messenger", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Pathology, University of Link\u00f6ping, Link\u00f6ping, Sweden", 
          "id": "http://www.grid.ac/institutes/grid.5640.7", 
          "name": [
            "Department of Pathology, University of Link\u00f6ping, Link\u00f6ping, Sweden"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Westermark", 
        "givenName": "G. T.", 
        "id": "sg:person.01345174777.77", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01345174777.77"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pathology, University of Uppsala, Uppsala, Sweden", 
          "id": "http://www.grid.ac/institutes/grid.8993.b", 
          "name": [
            "Department of Pathology, University of Link\u00f6ping, Link\u00f6ping, Sweden", 
            "Department of Pathology, University of Uppsala, Uppsala, Sweden"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Christmanson", 
        "givenName": "L.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Histochemistry, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK", 
          "id": "http://www.grid.ac/institutes/grid.413629.b", 
          "name": [
            "Department of Histochemistry, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Terenghi", 
        "givenName": "G.", 
        "id": "sg:person.01012162261.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01012162261.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Surgery, University of Link\u00f6ping, Link\u00f6ping, Sweden", 
          "id": "http://www.grid.ac/institutes/grid.5640.7", 
          "name": [
            "Department of Surgery, University of Link\u00f6ping, Link\u00f6ping, Sweden"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Permerth", 
        "givenName": "J.", 
        "id": "sg:person.0746750552.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0746750552.51"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pathology, University of Uppsala, Uppsala, Sweden", 
          "id": "http://www.grid.ac/institutes/grid.8993.b", 
          "name": [
            "Department of Pathology, University of Uppsala, Uppsala, Sweden"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Betsholtz", 
        "givenName": "C.", 
        "id": "sg:person.01273525553.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01273525553.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Surgery, University of Link\u00f6ping, Link\u00f6ping, Sweden", 
          "id": "http://www.grid.ac/institutes/grid.5640.7", 
          "name": [
            "Department of Surgery, University of Link\u00f6ping, Link\u00f6ping, Sweden"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Larsson", 
        "givenName": "J.", 
        "id": "sg:person.0606410663.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0606410663.46"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Histochemistry, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK", 
          "id": "http://www.grid.ac/institutes/grid.413629.b", 
          "name": [
            "Department of Histochemistry, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Polak", 
        "givenName": "J. M.", 
        "id": "sg:person.0670441457.36", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0670441457.36"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pathology Faculty of Health Sciences, University Hospital, S-581 85, Link\u00f6ping, Sweden", 
          "id": "http://www.grid.ac/institutes/grid.411384.b", 
          "name": [
            "Department of Pathology, University of Link\u00f6ping, Link\u00f6ping, Sweden", 
            "Department of Pathology Faculty of Health Sciences, University Hospital, S-581 85, Link\u00f6ping, Sweden"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Westermark", 
        "givenName": "P.", 
        "id": "sg:person.01006211233.89", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01006211233.89"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/bf00404025", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031992201", 
          "https://doi.org/10.1007/bf00404025"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00401195", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011721008", 
          "https://doi.org/10.1007/bf00401195"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00221649", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023661065", 
          "https://doi.org/10.1007/bf00221649"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00401051", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018870446", 
          "https://doi.org/10.1007/bf00401051"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00285291", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051998306", 
          "https://doi.org/10.1007/bf00285291"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00500385", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001244111", 
          "https://doi.org/10.1007/bf00500385"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/335632a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007052076", 
          "https://doi.org/10.1038/335632a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00400848", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019757701", 
          "https://doi.org/10.1007/bf00400848"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00251821", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020239032", 
          "https://doi.org/10.1007/bf00251821"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00274799", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1079687840", 
          "https://doi.org/10.1007/bf00274799"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1993-04", 
    "datePublishedReg": "1993-04-01", 
    "description": "Islet amyloid polypeptide which is normally coexpressed with insulin in beta cells, forms amyloid deposits especially in islets of Type 2 (non-insulin-dependent) diabetic subjects. Occurrence of islet amyloid is paradoxically associated with loss of islet amyloid polypeptide immunoreactivity in beta cells. The present study was undertaken to examine whether the islet amyloid polypeptide gene is expressed in islets with decreased islet amyloid polypeptide immunoreactivity. Pancreatic tissue from 14 patients, 7 with Type 2 diabetes and 7 non-diabetic, were obtained at autopsy or surgery and studied for islet amyloid polypeptide expression by in situ hybridization and for presence of insulin and islet amyloid polypeptide by immunohistochemistry. Six of the specimens from the diabetic and three of those from the non-diabetic patients had varying degrees of islet amyloid polypeptide-derived islet amyloid. Amyloid deposits were associated with decreased numbers of beta cells with islet amyloid polypeptide immunoreactivity despite an apparent normal frequency of insulin-containing cells. This discrepancy might reflect an alteration in islet amyloid polypeptide production or processing at a transcriptional or post-transcriptional level. In contrast to the varying immunohistochemical patterns, islets of all categories showed strong labelling using an islet amyloid polypeptide probe for in situ hybridization. It is concluded that islet amyloid polypeptide production is not altered at the transcriptional level. The following possibilities remain: (1) islet amyloid polypeptide production may be altered at a post-transcriptional level or (2) that islet amyloid polypeptide production is normal but the reduced immunoreactivity of the cells reflects a reduced storage of IAPP in secretory granules. We favour the second possibility since islet amyloid deposition is incompatible with reduced islet amyloid polypeptide synthesis.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/bf00400235", 
    "inLanguage": "en", 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1001482", 
        "issn": [
          "0012-186X", 
          "1432-0428"
        ], 
        "name": "Diabetologia", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "4", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "36"
      }
    ], 
    "keywords": [
      "islet amyloid polypeptide immunoreactivity", 
      "polypeptide immunoreactivity", 
      "beta cells", 
      "amyloid deposits", 
      "islet amyloid", 
      "non-diabetic patients", 
      "type 2 diabetic subjects", 
      "islet amyloid polypeptide expression", 
      "insulin-containing cells", 
      "type 2 diabetes", 
      "islet amyloid deposition", 
      "islet amyloid polypeptide gene", 
      "situ hybridization", 
      "human pancreatic islets", 
      "presence of insulin", 
      "diabetic subjects", 
      "islet amyloid polypeptide", 
      "amyloid deposition", 
      "demonstration of mRNA", 
      "immunohistochemical pattern", 
      "pancreatic tissue", 
      "pancreatic islets", 
      "polypeptide production", 
      "immunoreactivity", 
      "decreased number", 
      "islets", 
      "amyloid polypeptide", 
      "strong labeling", 
      "amyloid", 
      "patients", 
      "polypeptide expression", 
      "insulin", 
      "post-transcriptional level", 
      "secretory granules", 
      "present study", 
      "cells", 
      "polypeptide gene", 
      "normal frequency", 
      "diabetics", 
      "diabetes", 
      "immunohistochemistry", 
      "transcriptional level", 
      "levels", 
      "subjects", 
      "alterations", 
      "tissue", 
      "IAPP", 
      "mRNA", 
      "hybridization", 
      "polypeptide synthesis", 
      "expression", 
      "production", 
      "study", 
      "labeling", 
      "specimens", 
      "granules", 
      "occurrence", 
      "contrast", 
      "genes", 
      "loss", 
      "presence", 
      "second possibility", 
      "possibility", 
      "frequency", 
      "polypeptide", 
      "categories", 
      "patterns", 
      "demonstration", 
      "number", 
      "degree", 
      "discrepancy", 
      "deposits", 
      "form", 
      "probe", 
      "synthesis", 
      "polypeptide probe", 
      "deposition", 
      "processing", 
      "storage", 
      "amyloid polypeptide immunoreactivity", 
      "amyloid polypeptide gene", 
      "amyloid polypeptide expression", 
      "islet amyloid polypeptide-derived islet amyloid", 
      "amyloid polypeptide-derived islet amyloid", 
      "polypeptide-derived islet amyloid", 
      "apparent normal frequency", 
      "islet amyloid polypeptide production", 
      "amyloid polypeptide production", 
      "islet amyloid polypeptide probe", 
      "amyloid polypeptide probe", 
      "storage of IAPP", 
      "islet amyloid polypeptide synthesis", 
      "amyloid polypeptide synthesis"
    ], 
    "name": "Islet amyloid polypeptide: demonstration of mRNA in human pancreatic islets by in situ hybridization in islets with and without amyloid deposits", 
    "pagination": "323-328", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1020885656"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/bf00400235"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "8477877"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/bf00400235", 
      "https://app.dimensions.ai/details/publication/pub.1020885656"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-01-01T18:05", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220101/entities/gbq_results/article/article_226.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/bf00400235"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/bf00400235'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/bf00400235'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/bf00400235'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/bf00400235'


 

This table displays all metadata directly associated to this object as RDF triples.

312 TRIPLES      22 PREDICATES      144 URIs      126 LITERALS      21 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/bf00400235 schema:about N0093bb2446134122bfa845b3c315c53d
2 N0e8ef61ecd5c4372be9ffce06c3d7dab
3 N11fd065c59ef4161bd256431e80a5062
4 N13cae4df83d5495d91e8737729e007b2
5 N1808322ea84e480fa0830332205da0ae
6 N3a53ae82660e4733ae8e127c76d7bd19
7 N5980ee008ab14f5ab512fd947db4e73d
8 N75588e8eb1b7475e816069fe90ddecca
9 N78cfd94b1c53454eabed9fac8b00a192
10 N9fe660d54ea44702b751ce1911193024
11 Nacca65c29e9e4cc88306341ffb3d991b
12 Nbb58390784e14412858248700783bb21
13 Nd2d075b3625a48f6b90d4221ffb3fe5e
14 Nff6d6f93a96b42cd823f18a43fa0c3b9
15 anzsrc-for:11
16 anzsrc-for:1103
17 schema:author Nbc57b7e4d57141e1902b2588324af035
18 schema:citation sg:pub.10.1007/bf00221649
19 sg:pub.10.1007/bf00251821
20 sg:pub.10.1007/bf00274799
21 sg:pub.10.1007/bf00285291
22 sg:pub.10.1007/bf00400848
23 sg:pub.10.1007/bf00401051
24 sg:pub.10.1007/bf00401195
25 sg:pub.10.1007/bf00404025
26 sg:pub.10.1007/bf00500385
27 sg:pub.10.1038/335632a0
28 schema:datePublished 1993-04
29 schema:datePublishedReg 1993-04-01
30 schema:description Islet amyloid polypeptide which is normally coexpressed with insulin in beta cells, forms amyloid deposits especially in islets of Type 2 (non-insulin-dependent) diabetic subjects. Occurrence of islet amyloid is paradoxically associated with loss of islet amyloid polypeptide immunoreactivity in beta cells. The present study was undertaken to examine whether the islet amyloid polypeptide gene is expressed in islets with decreased islet amyloid polypeptide immunoreactivity. Pancreatic tissue from 14 patients, 7 with Type 2 diabetes and 7 non-diabetic, were obtained at autopsy or surgery and studied for islet amyloid polypeptide expression by in situ hybridization and for presence of insulin and islet amyloid polypeptide by immunohistochemistry. Six of the specimens from the diabetic and three of those from the non-diabetic patients had varying degrees of islet amyloid polypeptide-derived islet amyloid. Amyloid deposits were associated with decreased numbers of beta cells with islet amyloid polypeptide immunoreactivity despite an apparent normal frequency of insulin-containing cells. This discrepancy might reflect an alteration in islet amyloid polypeptide production or processing at a transcriptional or post-transcriptional level. In contrast to the varying immunohistochemical patterns, islets of all categories showed strong labelling using an islet amyloid polypeptide probe for in situ hybridization. It is concluded that islet amyloid polypeptide production is not altered at the transcriptional level. The following possibilities remain: (1) islet amyloid polypeptide production may be altered at a post-transcriptional level or (2) that islet amyloid polypeptide production is normal but the reduced immunoreactivity of the cells reflects a reduced storage of IAPP in secretory granules. We favour the second possibility since islet amyloid deposition is incompatible with reduced islet amyloid polypeptide synthesis.
31 schema:genre article
32 schema:inLanguage en
33 schema:isAccessibleForFree true
34 schema:isPartOf N9caa2f66a2db439a9ee2880f0023713e
35 Nc528b1b5aa65489f92620f31eeb098e9
36 sg:journal.1001482
37 schema:keywords IAPP
38 alterations
39 amyloid
40 amyloid deposition
41 amyloid deposits
42 amyloid polypeptide
43 amyloid polypeptide expression
44 amyloid polypeptide gene
45 amyloid polypeptide immunoreactivity
46 amyloid polypeptide probe
47 amyloid polypeptide production
48 amyloid polypeptide synthesis
49 amyloid polypeptide-derived islet amyloid
50 apparent normal frequency
51 beta cells
52 categories
53 cells
54 contrast
55 decreased number
56 degree
57 demonstration
58 demonstration of mRNA
59 deposition
60 deposits
61 diabetes
62 diabetic subjects
63 diabetics
64 discrepancy
65 expression
66 form
67 frequency
68 genes
69 granules
70 human pancreatic islets
71 hybridization
72 immunohistochemical pattern
73 immunohistochemistry
74 immunoreactivity
75 insulin
76 insulin-containing cells
77 islet amyloid
78 islet amyloid deposition
79 islet amyloid polypeptide
80 islet amyloid polypeptide expression
81 islet amyloid polypeptide gene
82 islet amyloid polypeptide immunoreactivity
83 islet amyloid polypeptide probe
84 islet amyloid polypeptide production
85 islet amyloid polypeptide synthesis
86 islet amyloid polypeptide-derived islet amyloid
87 islets
88 labeling
89 levels
90 loss
91 mRNA
92 non-diabetic patients
93 normal frequency
94 number
95 occurrence
96 pancreatic islets
97 pancreatic tissue
98 patients
99 patterns
100 polypeptide
101 polypeptide expression
102 polypeptide gene
103 polypeptide immunoreactivity
104 polypeptide probe
105 polypeptide production
106 polypeptide synthesis
107 polypeptide-derived islet amyloid
108 possibility
109 post-transcriptional level
110 presence
111 presence of insulin
112 present study
113 probe
114 processing
115 production
116 second possibility
117 secretory granules
118 situ hybridization
119 specimens
120 storage
121 storage of IAPP
122 strong labeling
123 study
124 subjects
125 synthesis
126 tissue
127 transcriptional level
128 type 2 diabetes
129 type 2 diabetic subjects
130 schema:name Islet amyloid polypeptide: demonstration of mRNA in human pancreatic islets by in situ hybridization in islets with and without amyloid deposits
131 schema:pagination 323-328
132 schema:productId N8bd1640099734d7c935ee3f3a923cb6b
133 Na783805cbf5240d0891c7f082dcfdcd5
134 Nc46833c90f9140338807842ceb64e96b
135 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020885656
136 https://doi.org/10.1007/bf00400235
137 schema:sdDatePublished 2022-01-01T18:05
138 schema:sdLicense https://scigraph.springernature.com/explorer/license/
139 schema:sdPublisher Nfac5494bcdae48a38b174d5b987364d3
140 schema:url https://doi.org/10.1007/bf00400235
141 sgo:license sg:explorer/license/
142 sgo:sdDataset articles
143 rdf:type schema:ScholarlyArticle
144 N0093bb2446134122bfa845b3c315c53d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Aged, 80 and over
146 rdf:type schema:DefinedTerm
147 N0887023d676e416b8d132e6acbe7f907 rdf:first sg:person.01273525553.31
148 rdf:rest N0b068e40a6bd4302927a947581e5543f
149 N0b068e40a6bd4302927a947581e5543f rdf:first sg:person.0606410663.46
150 rdf:rest N4e4d76579d9548f98ad8c62271236f85
151 N0e8ef61ecd5c4372be9ffce06c3d7dab schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Female
153 rdf:type schema:DefinedTerm
154 N11fd065c59ef4161bd256431e80a5062 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Islets of Langerhans
156 rdf:type schema:DefinedTerm
157 N13cae4df83d5495d91e8737729e007b2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Diabetes Mellitus, Type 2
159 rdf:type schema:DefinedTerm
160 N1808322ea84e480fa0830332205da0ae schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
161 schema:name Amyloid
162 rdf:type schema:DefinedTerm
163 N2185c944611142bab3ce1831eae37fca rdf:first sg:person.0746750552.51
164 rdf:rest N0887023d676e416b8d132e6acbe7f907
165 N26c5032c0a5e4594b22e4f6eb64842fc schema:affiliation grid-institutes:grid.8993.b
166 schema:familyName Christmanson
167 schema:givenName L.
168 rdf:type schema:Person
169 N3a53ae82660e4733ae8e127c76d7bd19 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
170 schema:name In Situ Hybridization
171 rdf:type schema:DefinedTerm
172 N4e4d76579d9548f98ad8c62271236f85 rdf:first sg:person.0670441457.36
173 rdf:rest Nc17eab7a63dc45108311f159d44f7513
174 N5980ee008ab14f5ab512fd947db4e73d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
175 schema:name RNA, Messenger
176 rdf:type schema:DefinedTerm
177 N75588e8eb1b7475e816069fe90ddecca schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
178 schema:name Immunohistochemistry
179 rdf:type schema:DefinedTerm
180 N78cfd94b1c53454eabed9fac8b00a192 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
181 schema:name Humans
182 rdf:type schema:DefinedTerm
183 N8bd1640099734d7c935ee3f3a923cb6b schema:name dimensions_id
184 schema:value pub.1020885656
185 rdf:type schema:PropertyValue
186 N9caa2f66a2db439a9ee2880f0023713e schema:volumeNumber 36
187 rdf:type schema:PublicationVolume
188 N9fe660d54ea44702b751ce1911193024 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
189 schema:name Islet Amyloid Polypeptide
190 rdf:type schema:DefinedTerm
191 Na783805cbf5240d0891c7f082dcfdcd5 schema:name pubmed_id
192 schema:value 8477877
193 rdf:type schema:PropertyValue
194 Nacca65c29e9e4cc88306341ffb3d991b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
195 schema:name Aged
196 rdf:type schema:DefinedTerm
197 Nbb42f23c7eb2450b9be7bc3afbad714d rdf:first sg:person.01012162261.44
198 rdf:rest N2185c944611142bab3ce1831eae37fca
199 Nbb58390784e14412858248700783bb21 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
200 schema:name Insulin
201 rdf:type schema:DefinedTerm
202 Nbc57b7e4d57141e1902b2588324af035 rdf:first sg:person.01345174777.77
203 rdf:rest Nd559516f388a458fa1e8fbedaefb460e
204 Nc17eab7a63dc45108311f159d44f7513 rdf:first sg:person.01006211233.89
205 rdf:rest rdf:nil
206 Nc46833c90f9140338807842ceb64e96b schema:name doi
207 schema:value 10.1007/bf00400235
208 rdf:type schema:PropertyValue
209 Nc528b1b5aa65489f92620f31eeb098e9 schema:issueNumber 4
210 rdf:type schema:PublicationIssue
211 Nd2d075b3625a48f6b90d4221ffb3fe5e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
212 schema:name Adult
213 rdf:type schema:DefinedTerm
214 Nd559516f388a458fa1e8fbedaefb460e rdf:first N26c5032c0a5e4594b22e4f6eb64842fc
215 rdf:rest Nbb42f23c7eb2450b9be7bc3afbad714d
216 Nfac5494bcdae48a38b174d5b987364d3 schema:name Springer Nature - SN SciGraph project
217 rdf:type schema:Organization
218 Nff6d6f93a96b42cd823f18a43fa0c3b9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
219 schema:name Male
220 rdf:type schema:DefinedTerm
221 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
222 schema:name Medical and Health Sciences
223 rdf:type schema:DefinedTerm
224 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
225 schema:name Clinical Sciences
226 rdf:type schema:DefinedTerm
227 sg:journal.1001482 schema:issn 0012-186X
228 1432-0428
229 schema:name Diabetologia
230 schema:publisher Springer Nature
231 rdf:type schema:Periodical
232 sg:person.01006211233.89 schema:affiliation grid-institutes:grid.411384.b
233 schema:familyName Westermark
234 schema:givenName P.
235 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01006211233.89
236 rdf:type schema:Person
237 sg:person.01012162261.44 schema:affiliation grid-institutes:grid.413629.b
238 schema:familyName Terenghi
239 schema:givenName G.
240 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01012162261.44
241 rdf:type schema:Person
242 sg:person.01273525553.31 schema:affiliation grid-institutes:grid.8993.b
243 schema:familyName Betsholtz
244 schema:givenName C.
245 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01273525553.31
246 rdf:type schema:Person
247 sg:person.01345174777.77 schema:affiliation grid-institutes:grid.5640.7
248 schema:familyName Westermark
249 schema:givenName G. T.
250 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01345174777.77
251 rdf:type schema:Person
252 sg:person.0606410663.46 schema:affiliation grid-institutes:grid.5640.7
253 schema:familyName Larsson
254 schema:givenName J.
255 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0606410663.46
256 rdf:type schema:Person
257 sg:person.0670441457.36 schema:affiliation grid-institutes:grid.413629.b
258 schema:familyName Polak
259 schema:givenName J. M.
260 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0670441457.36
261 rdf:type schema:Person
262 sg:person.0746750552.51 schema:affiliation grid-institutes:grid.5640.7
263 schema:familyName Permerth
264 schema:givenName J.
265 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0746750552.51
266 rdf:type schema:Person
267 sg:pub.10.1007/bf00221649 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023661065
268 https://doi.org/10.1007/bf00221649
269 rdf:type schema:CreativeWork
270 sg:pub.10.1007/bf00251821 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020239032
271 https://doi.org/10.1007/bf00251821
272 rdf:type schema:CreativeWork
273 sg:pub.10.1007/bf00274799 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079687840
274 https://doi.org/10.1007/bf00274799
275 rdf:type schema:CreativeWork
276 sg:pub.10.1007/bf00285291 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051998306
277 https://doi.org/10.1007/bf00285291
278 rdf:type schema:CreativeWork
279 sg:pub.10.1007/bf00400848 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019757701
280 https://doi.org/10.1007/bf00400848
281 rdf:type schema:CreativeWork
282 sg:pub.10.1007/bf00401051 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018870446
283 https://doi.org/10.1007/bf00401051
284 rdf:type schema:CreativeWork
285 sg:pub.10.1007/bf00401195 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011721008
286 https://doi.org/10.1007/bf00401195
287 rdf:type schema:CreativeWork
288 sg:pub.10.1007/bf00404025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031992201
289 https://doi.org/10.1007/bf00404025
290 rdf:type schema:CreativeWork
291 sg:pub.10.1007/bf00500385 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001244111
292 https://doi.org/10.1007/bf00500385
293 rdf:type schema:CreativeWork
294 sg:pub.10.1038/335632a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007052076
295 https://doi.org/10.1038/335632a0
296 rdf:type schema:CreativeWork
297 grid-institutes:grid.411384.b schema:alternateName Department of Pathology Faculty of Health Sciences, University Hospital, S-581 85, Linköping, Sweden
298 schema:name Department of Pathology Faculty of Health Sciences, University Hospital, S-581 85, Linköping, Sweden
299 Department of Pathology, University of Linköping, Linköping, Sweden
300 rdf:type schema:Organization
301 grid-institutes:grid.413629.b schema:alternateName Department of Histochemistry, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK
302 schema:name Department of Histochemistry, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK
303 rdf:type schema:Organization
304 grid-institutes:grid.5640.7 schema:alternateName Department of Pathology, University of Linköping, Linköping, Sweden
305 Department of Surgery, University of Linköping, Linköping, Sweden
306 schema:name Department of Pathology, University of Linköping, Linköping, Sweden
307 Department of Surgery, University of Linköping, Linköping, Sweden
308 rdf:type schema:Organization
309 grid-institutes:grid.8993.b schema:alternateName Department of Pathology, University of Uppsala, Uppsala, Sweden
310 schema:name Department of Pathology, University of Linköping, Linköping, Sweden
311 Department of Pathology, University of Uppsala, Uppsala, Sweden
312 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...