Leukoencephalopathy following high-dose intravenous methotrexate chemotherapy: Quantitative assessment of white matter attenuation using computed tomography View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1978-12

AUTHORS

J. C. Allen, H. T. Thaler, M. D. F. Deck, D. A. Rottenberg

ABSTRACT

A clinical or subclinical leukoencephalopathy occurs in some children after treatment of acute lymphatic leukemia with prophylactic cranial radiation therapy and parenteral or intrathecal methotrexate. We have observed a similar clinical leukoencephalopathy in patients with bone tumors treated with intravenous high-dose methotrexate and citrovorum factor without cranial irradiation. CT scans of such patients may indicate decreased white matter attenuation, but visual appraisal of this phenomenon is occasionally misleading. A computerized method for analyzing white matter hypodensity by determining the mean attenuation coefficient for one or several contiguous CT slices has therefore been developed. Serial comparisons of this mean attenuation coefficient appear to be more reliable than simple visual appraisal. More... »

PAGES

44-47

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00395199

DOI

http://dx.doi.org/10.1007/bf00395199

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1003724570

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/740209


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