Ionic currents contributing to the action potential in single ventricular myocytes of the guinea pig studied with action potential clamp View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1990-05

AUTHORS

T. Doerr, R. Denger, A. Doerr, W. Trautwein

ABSTRACT

With the action potential clamp procedure we studied the contribution of various ionic currents to the action potential in single ventricular myocytes. Action potentials were elicited by a current pulse through the suction pipette and recorded by a computer. A representative action potential was then repetitively replayed to the same cell under voltage-clamp conditions. Successive pharmacological blocks of ionic currents allowed for the first time the measurement of the contribution of the L-type calcium current (ICa) and the [Ca2+]i-activated currents as well as the potassium current to the action potential. Experiments using caffeine as a tool to increase calcium release from the sarcoplasmic reticulum supported the idea that INaCa contributes to the plateau during the second half of the action potential and even lasts into diastole, whereas strong elevation of the intracellular [Ca]i during the action potential additionally activated the non-specific cation channel. More... »

PAGES

230-237

References to SciGraph publications

  • 1986-02. Na-Ca exchange current in mammalian heart cells in NATURE
  • 1987-06. Evidence for inhibition by ICS 205-930 and stimulation by BRL 34915 of K+ conductance in cardiac muscle in NAUNYN-SCHMIEDEBERG'S ARCHIVES OF PHARMACOLOGY
  • 1972-12. Differentiation of the transmembrane Na and Ca channels in mammalian cardiac fibres by the use of specific inhibitors in PFLÜGERS ARCHIV - EUROPEAN JOURNAL OF PHYSIOLOGY
  • 1986-08. Modulation of Ca current during the phosphorylation cycle in the guinea pig heart in PFLÜGERS ARCHIV - EUROPEAN JOURNAL OF PHYSIOLOGY
  • 1985. Voltage-Dependent Gating of Single Calcium Channels in the Cardiac Cell Membrane and Its Modulation by Drugs in CALCIUM AND CELL PHYSIOLOGY
  • 1982-08. Injection of subunits of cyclic AMP-dependent protein kinase into cardiac myocytes modulates Ca2+ current in NATURE
  • 1982-10. Calcium tolerant ventricular myocytes prepared by preincubation in a “KB medium” in PFLÜGERS ARCHIV - EUROPEAN JOURNAL OF PHYSIOLOGY
  • 1986-02. Identification of Na-Ca exchange current in single cardiac myocytes in NATURE
  • 1981-12. Inward current channels activated by intracellular Ca in cultured cardiac cells in NATURE
  • 1989-04-01. Sodium and potassium currents recorded during an action potential in EUROPEAN BIOPHYSICS JOURNAL
  • 1981-08. Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches in PFLÜGERS ARCHIV - EUROPEAN JOURNAL OF PHYSIOLOGY
  • 1989-04. Calcium currents in single SA nodal cells of the rabbit heart studied with action potential clamp in PFLÜGERS ARCHIV - EUROPEAN JOURNAL OF PHYSIOLOGY
  • 1964-03. Voltage clamp technique in mammalian cardiac fibres in PFLÜGERS ARCHIV - EUROPEAN JOURNAL OF PHYSIOLOGY
  • 1986. Activation and Inactivation of Single Calcium Channels in Cardiac Cells in CALCIUM ELECTROGENESIS AND NEURONAL FUNCTIONING
  • 1985-10. On the mechanism of β-adrenergic regulation of the Ca channel in the guinea-pig heart in PFLÜGERS ARCHIV - EUROPEAN JOURNAL OF PHYSIOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/bf00392058

    DOI

    http://dx.doi.org/10.1007/bf00392058

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1046545723

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/1696371


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