Ionic currents contributing to the action potential in single ventricular myocytes of the guinea pig studied with action potential clamp View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1990-05

AUTHORS

T. Doerr, R. Denger, A. Doerr, W. Trautwein

ABSTRACT

With the action potential clamp procedure we studied the contribution of various ionic currents to the action potential in single ventricular myocytes. Action potentials were elicited by a current pulse through the suction pipette and recorded by a computer. A representative action potential was then repetitively replayed to the same cell under voltage-clamp conditions. Successive pharmacological blocks of ionic currents allowed for the first time the measurement of the contribution of the L-type calcium current (ICa) and the [Ca2+]i-activated currents as well as the potassium current to the action potential. Experiments using caffeine as a tool to increase calcium release from the sarcoplasmic reticulum supported the idea that INaCa contributes to the plateau during the second half of the action potential and even lasts into diastole, whereas strong elevation of the intracellular [Ca]i during the action potential additionally activated the non-specific cation channel. More... »

PAGES

230-237

References to SciGraph publications

  • 1986-02. Na-Ca exchange current in mammalian heart cells in NATURE
  • 1987-06. Evidence for inhibition by ICS 205-930 and stimulation by BRL 34915 of K+ conductance in cardiac muscle in NAUNYN-SCHMIEDEBERG'S ARCHIVES OF PHARMACOLOGY
  • 1972-12. Differentiation of the transmembrane Na and Ca channels in mammalian cardiac fibres by the use of specific inhibitors in PFLÜGERS ARCHIV - EUROPEAN JOURNAL OF PHYSIOLOGY
  • 1986-08. Modulation of Ca current during the phosphorylation cycle in the guinea pig heart in PFLÜGERS ARCHIV - EUROPEAN JOURNAL OF PHYSIOLOGY
  • 1985. Voltage-Dependent Gating of Single Calcium Channels in the Cardiac Cell Membrane and Its Modulation by Drugs in CALCIUM AND CELL PHYSIOLOGY
  • 1982-08. Injection of subunits of cyclic AMP-dependent protein kinase into cardiac myocytes modulates Ca2+ current in NATURE
  • 1982-10. Calcium tolerant ventricular myocytes prepared by preincubation in a “KB medium” in PFLÜGERS ARCHIV - EUROPEAN JOURNAL OF PHYSIOLOGY
  • 1986-02. Identification of Na-Ca exchange current in single cardiac myocytes in NATURE
  • 1981-12. Inward current channels activated by intracellular Ca in cultured cardiac cells in NATURE
  • 1989-04-01. Sodium and potassium currents recorded during an action potential in EUROPEAN BIOPHYSICS JOURNAL
  • 1981-08. Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches in PFLÜGERS ARCHIV - EUROPEAN JOURNAL OF PHYSIOLOGY
  • 1989-04. Calcium currents in single SA nodal cells of the rabbit heart studied with action potential clamp in PFLÜGERS ARCHIV - EUROPEAN JOURNAL OF PHYSIOLOGY
  • 1964-03. Voltage clamp technique in mammalian cardiac fibres in PFLÜGERS ARCHIV - EUROPEAN JOURNAL OF PHYSIOLOGY
  • 1986. Activation and Inactivation of Single Calcium Channels in Cardiac Cells in CALCIUM ELECTROGENESIS AND NEURONAL FUNCTIONING
  • 1985-10. On the mechanism of β-adrenergic regulation of the Ca channel in the guinea-pig heart in PFLÜGERS ARCHIV - EUROPEAN JOURNAL OF PHYSIOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/bf00392058

    DOI

    http://dx.doi.org/10.1007/bf00392058

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1046545723

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/1696371


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1116", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical Physiology", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Action Potentials", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Caffeine", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Calcium", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Calcium Channels", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Carrier Proteins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Guinea Pigs", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Heart", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Ion Channels", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Ion Exchange", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Myocardium", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Potassium", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Potassium Channels", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Sodium-Calcium Exchanger", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "II. Physiologisches Institut, Universit\u00e4t des Saarlandes, D-6650, Homburg/Saar, Federal Republic of Germany", 
              "id": "http://www.grid.ac/institutes/grid.11749.3a", 
              "name": [
                "II. Physiologisches Institut, Universit\u00e4t des Saarlandes, D-6650, Homburg/Saar, Federal Republic of Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Doerr", 
            "givenName": "T.", 
            "id": "sg:person.01233036267.41", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01233036267.41"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "II. Physiologisches Institut, Universit\u00e4t des Saarlandes, D-6650, Homburg/Saar, Federal Republic of Germany", 
              "id": "http://www.grid.ac/institutes/grid.11749.3a", 
              "name": [
                "II. Physiologisches Institut, Universit\u00e4t des Saarlandes, D-6650, Homburg/Saar, Federal Republic of Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Denger", 
            "givenName": "R.", 
            "id": "sg:person.01301151467.01", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01301151467.01"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "II. Physiologisches Institut, Universit\u00e4t des Saarlandes, D-6650, Homburg/Saar, Federal Republic of Germany", 
              "id": "http://www.grid.ac/institutes/grid.11749.3a", 
              "name": [
                "II. Physiologisches Institut, Universit\u00e4t des Saarlandes, D-6650, Homburg/Saar, Federal Republic of Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Doerr", 
            "givenName": "A.", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "II. Physiologisches Institut, Universit\u00e4t des Saarlandes, D-6650, Homburg/Saar, Federal Republic of Germany", 
              "id": "http://www.grid.ac/institutes/grid.11749.3a", 
              "name": [
                "II. Physiologisches Institut, Universit\u00e4t des Saarlandes, D-6650, Homburg/Saar, Federal Republic of Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Trautwein", 
            "givenName": "W.", 
            "id": "sg:person.01010003233.11", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01010003233.11"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/294752a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018721316", 
              "https://doi.org/10.1038/294752a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/319597a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026526318", 
              "https://doi.org/10.1038/319597a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00257145", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001902228", 
              "https://doi.org/10.1007/bf00257145"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/319596a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044733136", 
              "https://doi.org/10.1038/319596a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00656997", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014806333", 
              "https://doi.org/10.1007/bf00656997"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00166988", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031497837", 
              "https://doi.org/10.1007/bf00166988"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-3-642-70070-5_3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016004375", 
              "https://doi.org/10.1007/978-3-642-70070-5_3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-3-642-70744-5_3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1089780406", 
              "https://doi.org/10.1007/978-3-642-70744-5_3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00412615", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051590079", 
              "https://doi.org/10.1007/bf00412615"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00586221", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047748458", 
              "https://doi.org/10.1007/bf00586221"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00580662", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021059232", 
              "https://doi.org/10.1007/bf00580662"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00584963", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039653041", 
              "https://doi.org/10.1007/bf00584963"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00581808", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012230866", 
              "https://doi.org/10.1007/bf00581808"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/298576a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053152341", 
              "https://doi.org/10.1038/298576a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00582573", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029037032", 
              "https://doi.org/10.1007/bf00582573"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "1990-05", 
        "datePublishedReg": "1990-05-01", 
        "description": "With the action potential clamp procedure we studied the contribution of various ionic currents to the action potential in single ventricular myocytes. Action potentials were elicited by a current pulse through the suction pipette and recorded by a computer. A representative action potential was then repetitively replayed to the same cell under voltage-clamp conditions. Successive pharmacological blocks of ionic currents allowed for the first time the measurement of the contribution of the L-type calcium current (ICa) and the [Ca2+]i-activated currents as well as the potassium current to the action potential. Experiments using caffeine as a tool to increase calcium release from the sarcoplasmic reticulum supported the idea that INaCa contributes to the plateau during the second half of the action potential and even lasts into diastole, whereas strong elevation of the intracellular [Ca]i during the action potential additionally activated the non-specific cation channel.", 
        "genre": "article", 
        "id": "sg:pub.10.1007/bf00392058", 
        "inLanguage": "en", 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1005222", 
            "issn": [
              "0031-6768", 
              "1432-2013"
            ], 
            "name": "Pfl\u00fcgers Archiv - European Journal of Physiology", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "3", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "416"
          }
        ], 
        "keywords": [
          "single ventricular myocytes", 
          "action potentials", 
          "ventricular myocytes", 
          "type calcium current", 
          "non-specific cation channels", 
          "voltage-clamp conditions", 
          "action potential clamp", 
          "ionic currents", 
          "clamp procedure", 
          "calcium current", 
          "pharmacological block", 
          "guinea pigs", 
          "calcium release", 
          "cation channels", 
          "sarcoplasmic reticulum", 
          "strong elevation", 
          "myocytes", 
          "suction pipette", 
          "same cells", 
          "INaCa", 
          "diastole", 
          "clamp", 
          "intracellular", 
          "pigs", 
          "elevation", 
          "caffeine", 
          "pipette", 
          "cells", 
          "release", 
          "potential", 
          "half", 
          "reticulum", 
          "current pulses", 
          "potassium", 
          "procedure", 
          "first time", 
          "time", 
          "second half", 
          "block", 
          "tool", 
          "contribution", 
          "conditions", 
          "measurements", 
          "current", 
          "plateau", 
          "channels", 
          "pulses", 
          "experiments", 
          "computer", 
          "idea"
        ], 
        "name": "Ionic currents contributing to the action potential in single ventricular myocytes of the guinea pig studied with action potential clamp", 
        "pagination": "230-237", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1046545723"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/bf00392058"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "1696371"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/bf00392058", 
          "https://app.dimensions.ai/details/publication/pub.1046545723"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-05-20T07:19", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20220519/entities/gbq_results/article/article_230.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1007/bf00392058"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/bf00392058'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/bf00392058'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/bf00392058'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/bf00392058'


     

    This table displays all metadata directly associated to this object as RDF triples.

    248 TRIPLES      22 PREDICATES      106 URIs      83 LITERALS      21 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/bf00392058 schema:about N0dedec531a134fc291c286ed5571c1cd
    2 N154d0565b7f7480aae5343a9072d25eb
    3 N216b4722bc9b489cae8c3a10c375ea87
    4 N2778c72ed2ad437187d401c62f0f3fef
    5 N2a6c80941cd04618bdcac046730baed3
    6 N2ca5ea5933ae4fb4b0b10e7275d146bb
    7 N4dfa967a0d924c3d956336d0c12aa290
    8 N749243257c7d41ca8fec6c3cb8ec0c2c
    9 N79e986ed002b4912a4286d7e05b0c17c
    10 N9b096f1b35b646fd89fe2bdd2f8b3930
    11 N9da2a6e282ad49d9a40cc4a1eca346d7
    12 Na155963c53cc409590b0ff8a3e5fd03f
    13 Nb328aeb5120c40efaae6c0cd4b4b940c
    14 Nfef89bf614d5454c934bc16eb47382e6
    15 anzsrc-for:11
    16 anzsrc-for:1116
    17 schema:author Nfed6c15a801d4d0cbf8e24f3b7c4391a
    18 schema:citation sg:pub.10.1007/978-3-642-70070-5_3
    19 sg:pub.10.1007/978-3-642-70744-5_3
    20 sg:pub.10.1007/bf00166988
    21 sg:pub.10.1007/bf00257145
    22 sg:pub.10.1007/bf00412615
    23 sg:pub.10.1007/bf00580662
    24 sg:pub.10.1007/bf00581808
    25 sg:pub.10.1007/bf00582573
    26 sg:pub.10.1007/bf00584963
    27 sg:pub.10.1007/bf00586221
    28 sg:pub.10.1007/bf00656997
    29 sg:pub.10.1038/294752a0
    30 sg:pub.10.1038/298576a0
    31 sg:pub.10.1038/319596a0
    32 sg:pub.10.1038/319597a0
    33 schema:datePublished 1990-05
    34 schema:datePublishedReg 1990-05-01
    35 schema:description With the action potential clamp procedure we studied the contribution of various ionic currents to the action potential in single ventricular myocytes. Action potentials were elicited by a current pulse through the suction pipette and recorded by a computer. A representative action potential was then repetitively replayed to the same cell under voltage-clamp conditions. Successive pharmacological blocks of ionic currents allowed for the first time the measurement of the contribution of the L-type calcium current (ICa) and the [Ca2+]i-activated currents as well as the potassium current to the action potential. Experiments using caffeine as a tool to increase calcium release from the sarcoplasmic reticulum supported the idea that INaCa contributes to the plateau during the second half of the action potential and even lasts into diastole, whereas strong elevation of the intracellular [Ca]i during the action potential additionally activated the non-specific cation channel.
    36 schema:genre article
    37 schema:inLanguage en
    38 schema:isAccessibleForFree false
    39 schema:isPartOf N69e6f855fd2c4d3082b36e7df0b39ce8
    40 N9a6b8a2b28974e83afedd10a8de64aae
    41 sg:journal.1005222
    42 schema:keywords INaCa
    43 action potential clamp
    44 action potentials
    45 block
    46 caffeine
    47 calcium current
    48 calcium release
    49 cation channels
    50 cells
    51 channels
    52 clamp
    53 clamp procedure
    54 computer
    55 conditions
    56 contribution
    57 current
    58 current pulses
    59 diastole
    60 elevation
    61 experiments
    62 first time
    63 guinea pigs
    64 half
    65 idea
    66 intracellular
    67 ionic currents
    68 measurements
    69 myocytes
    70 non-specific cation channels
    71 pharmacological block
    72 pigs
    73 pipette
    74 plateau
    75 potassium
    76 potential
    77 procedure
    78 pulses
    79 release
    80 reticulum
    81 same cells
    82 sarcoplasmic reticulum
    83 second half
    84 single ventricular myocytes
    85 strong elevation
    86 suction pipette
    87 time
    88 tool
    89 type calcium current
    90 ventricular myocytes
    91 voltage-clamp conditions
    92 schema:name Ionic currents contributing to the action potential in single ventricular myocytes of the guinea pig studied with action potential clamp
    93 schema:pagination 230-237
    94 schema:productId N3b13f0f29bc34bf794e81eaa221ebe09
    95 N45be051895f4482b87bab25a5b6333b8
    96 N7004daa86c014a60a5ea46a2b5e7b7bc
    97 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046545723
    98 https://doi.org/10.1007/bf00392058
    99 schema:sdDatePublished 2022-05-20T07:19
    100 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    101 schema:sdPublisher Nea93e0f6822d4ccb9e0ef6072359ec66
    102 schema:url https://doi.org/10.1007/bf00392058
    103 sgo:license sg:explorer/license/
    104 sgo:sdDataset articles
    105 rdf:type schema:ScholarlyArticle
    106 N0dedec531a134fc291c286ed5571c1cd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    107 schema:name Potassium
    108 rdf:type schema:DefinedTerm
    109 N154d0565b7f7480aae5343a9072d25eb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    110 schema:name Myocardium
    111 rdf:type schema:DefinedTerm
    112 N1e1529e8f8364c0081bf8dd82ed2f229 rdf:first sg:person.01010003233.11
    113 rdf:rest rdf:nil
    114 N216b4722bc9b489cae8c3a10c375ea87 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    115 schema:name Carrier Proteins
    116 rdf:type schema:DefinedTerm
    117 N2778c72ed2ad437187d401c62f0f3fef schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    118 schema:name Caffeine
    119 rdf:type schema:DefinedTerm
    120 N2a6c80941cd04618bdcac046730baed3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    121 schema:name Ion Channels
    122 rdf:type schema:DefinedTerm
    123 N2ca5ea5933ae4fb4b0b10e7275d146bb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    124 schema:name Guinea Pigs
    125 rdf:type schema:DefinedTerm
    126 N3b13f0f29bc34bf794e81eaa221ebe09 schema:name pubmed_id
    127 schema:value 1696371
    128 rdf:type schema:PropertyValue
    129 N45be051895f4482b87bab25a5b6333b8 schema:name dimensions_id
    130 schema:value pub.1046545723
    131 rdf:type schema:PropertyValue
    132 N4dfa967a0d924c3d956336d0c12aa290 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    133 schema:name Calcium
    134 rdf:type schema:DefinedTerm
    135 N69e6f855fd2c4d3082b36e7df0b39ce8 schema:volumeNumber 416
    136 rdf:type schema:PublicationVolume
    137 N7004daa86c014a60a5ea46a2b5e7b7bc schema:name doi
    138 schema:value 10.1007/bf00392058
    139 rdf:type schema:PropertyValue
    140 N749243257c7d41ca8fec6c3cb8ec0c2c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    141 schema:name Action Potentials
    142 rdf:type schema:DefinedTerm
    143 N79e986ed002b4912a4286d7e05b0c17c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    144 schema:name Sodium-Calcium Exchanger
    145 rdf:type schema:DefinedTerm
    146 N7e15f5c6a6494bf5a22057b1a983ba04 rdf:first Ne85746a771884a61a9b1bc13d8f8295f
    147 rdf:rest N1e1529e8f8364c0081bf8dd82ed2f229
    148 N9a6b8a2b28974e83afedd10a8de64aae schema:issueNumber 3
    149 rdf:type schema:PublicationIssue
    150 N9b096f1b35b646fd89fe2bdd2f8b3930 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    151 schema:name Ion Exchange
    152 rdf:type schema:DefinedTerm
    153 N9da2a6e282ad49d9a40cc4a1eca346d7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    154 schema:name Animals
    155 rdf:type schema:DefinedTerm
    156 Na155963c53cc409590b0ff8a3e5fd03f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    157 schema:name Potassium Channels
    158 rdf:type schema:DefinedTerm
    159 Nb328aeb5120c40efaae6c0cd4b4b940c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    160 schema:name Calcium Channels
    161 rdf:type schema:DefinedTerm
    162 Ne85746a771884a61a9b1bc13d8f8295f schema:affiliation grid-institutes:grid.11749.3a
    163 schema:familyName Doerr
    164 schema:givenName A.
    165 rdf:type schema:Person
    166 Nea93e0f6822d4ccb9e0ef6072359ec66 schema:name Springer Nature - SN SciGraph project
    167 rdf:type schema:Organization
    168 Neaee85911eae4df7866ef9780a60984c rdf:first sg:person.01301151467.01
    169 rdf:rest N7e15f5c6a6494bf5a22057b1a983ba04
    170 Nfed6c15a801d4d0cbf8e24f3b7c4391a rdf:first sg:person.01233036267.41
    171 rdf:rest Neaee85911eae4df7866ef9780a60984c
    172 Nfef89bf614d5454c934bc16eb47382e6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    173 schema:name Heart
    174 rdf:type schema:DefinedTerm
    175 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    176 schema:name Medical and Health Sciences
    177 rdf:type schema:DefinedTerm
    178 anzsrc-for:1116 schema:inDefinedTermSet anzsrc-for:
    179 schema:name Medical Physiology
    180 rdf:type schema:DefinedTerm
    181 sg:journal.1005222 schema:issn 0031-6768
    182 1432-2013
    183 schema:name Pflügers Archiv - European Journal of Physiology
    184 schema:publisher Springer Nature
    185 rdf:type schema:Periodical
    186 sg:person.01010003233.11 schema:affiliation grid-institutes:grid.11749.3a
    187 schema:familyName Trautwein
    188 schema:givenName W.
    189 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01010003233.11
    190 rdf:type schema:Person
    191 sg:person.01233036267.41 schema:affiliation grid-institutes:grid.11749.3a
    192 schema:familyName Doerr
    193 schema:givenName T.
    194 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01233036267.41
    195 rdf:type schema:Person
    196 sg:person.01301151467.01 schema:affiliation grid-institutes:grid.11749.3a
    197 schema:familyName Denger
    198 schema:givenName R.
    199 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01301151467.01
    200 rdf:type schema:Person
    201 sg:pub.10.1007/978-3-642-70070-5_3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016004375
    202 https://doi.org/10.1007/978-3-642-70070-5_3
    203 rdf:type schema:CreativeWork
    204 sg:pub.10.1007/978-3-642-70744-5_3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1089780406
    205 https://doi.org/10.1007/978-3-642-70744-5_3
    206 rdf:type schema:CreativeWork
    207 sg:pub.10.1007/bf00166988 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031497837
    208 https://doi.org/10.1007/bf00166988
    209 rdf:type schema:CreativeWork
    210 sg:pub.10.1007/bf00257145 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001902228
    211 https://doi.org/10.1007/bf00257145
    212 rdf:type schema:CreativeWork
    213 sg:pub.10.1007/bf00412615 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051590079
    214 https://doi.org/10.1007/bf00412615
    215 rdf:type schema:CreativeWork
    216 sg:pub.10.1007/bf00580662 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021059232
    217 https://doi.org/10.1007/bf00580662
    218 rdf:type schema:CreativeWork
    219 sg:pub.10.1007/bf00581808 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012230866
    220 https://doi.org/10.1007/bf00581808
    221 rdf:type schema:CreativeWork
    222 sg:pub.10.1007/bf00582573 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029037032
    223 https://doi.org/10.1007/bf00582573
    224 rdf:type schema:CreativeWork
    225 sg:pub.10.1007/bf00584963 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039653041
    226 https://doi.org/10.1007/bf00584963
    227 rdf:type schema:CreativeWork
    228 sg:pub.10.1007/bf00586221 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047748458
    229 https://doi.org/10.1007/bf00586221
    230 rdf:type schema:CreativeWork
    231 sg:pub.10.1007/bf00656997 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014806333
    232 https://doi.org/10.1007/bf00656997
    233 rdf:type schema:CreativeWork
    234 sg:pub.10.1038/294752a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018721316
    235 https://doi.org/10.1038/294752a0
    236 rdf:type schema:CreativeWork
    237 sg:pub.10.1038/298576a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053152341
    238 https://doi.org/10.1038/298576a0
    239 rdf:type schema:CreativeWork
    240 sg:pub.10.1038/319596a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044733136
    241 https://doi.org/10.1038/319596a0
    242 rdf:type schema:CreativeWork
    243 sg:pub.10.1038/319597a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026526318
    244 https://doi.org/10.1038/319597a0
    245 rdf:type schema:CreativeWork
    246 grid-institutes:grid.11749.3a schema:alternateName II. Physiologisches Institut, Universität des Saarlandes, D-6650, Homburg/Saar, Federal Republic of Germany
    247 schema:name II. Physiologisches Institut, Universität des Saarlandes, D-6650, Homburg/Saar, Federal Republic of Germany
    248 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...