Cytostatic activity of steroid linked nitrosoureas View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1984-07

AUTHORS

W. J. Zeller, J. Schreiber, A. D. Ho, D. Schmähl, G. Eisenbrand

ABSTRACT

First investigations on the therapeutic activity of a new group of steroid-linked N-(2-chloroethyl)-N-nitrosocarbamoyl-l-alanine esters (CNC-l-alanine esters) in a nitrosourea-sensitive rat leukemia (L 5222) characterized by a relatively high content of glucocorticoid binding sites are presented. Despite a considerable range of optimal and toxic doses of the different analogs, the respective therapeutic ratios do not appear to be significantly influenced by the nature of the carrier molecules to which CNC-l-alanine is attached. However several steroid-linked representatives are distinctly more active than CNC-l-alanine. The androsterone-3-ester and the dihydrotestosterone-17-ester, in particular effected high percentages of cures in contrast to CNC-l-alanine. More... »

PAGES

164-168

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00390991

DOI

http://dx.doi.org/10.1007/bf00390991

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1013262801

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/6746709


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