Feasible model for locoregional and systemic longterm administration of drugs and concomitant blood sampling in Sprague-Dawley rats View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1987-02

AUTHORS

J. L. Aguiar, R. Bartkowski, M. R. Berger, E. Petru, P. Schlag, D. Schmähl

ABSTRACT

This methodological study describes three surgical prodedures for locoregional and systemic drug administration, which are based on a similar experimental design. Cannulation of the arterial and portal access to the liver in comparison to the general venous system, and arterial access to the large intestine through a permanently implantable system, suitable for serial bolus injections and infusions in unrestrained rats, is presented (experiment I). Furthermore, an infusion system for longterm administration (experiment II) and a method for blood sampling during locoregional or systemic infusion procedures (experiment III) have been developed. The positioning and free flow of the catheters were checked by means of scintigraphy, administration of fluorescein under UV light and angiography in animals of experimental series I. After 7 days, no obstruction was detected. On day 15 and 30 following implantation 73.3% and 58.3% of the animals, respectively, showed unimpeded flow through the catheter system. The methods described here were well tolerated by the animals without alteration of their general condition and are currently in use in a series of chemotherapeutic and pharmacokinetic investigations. More... »

PAGES

27-30

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00389963

DOI

http://dx.doi.org/10.1007/bf00389963

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1002871991

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/3818776


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206 schema:name Department of Surgery, University of Heidelberg, Im Neuenheimer Feld 110, D-6900, Heidelberg, Federal Republic of Germany
207 rdf:type schema:Organization
 




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