Biphasic short-circuit current response to noradrenaline mediated by Ca2+ and cAMP in cultured rat epididymal epithelium View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1994-03

AUTHORS

A. Y. H. Leung, P. Y. D. Wong

ABSTRACT

A study was carried out to investigate the short-circuit current (Isc) response to noradrenaline (NA) and the signal transduction mechanisms involved in cultured rat cauda epididymal epithelium. In normal Krebs-Henseleit solution, NA (10 μmol · l−1) added basolaterally elicited a biphasic Isc response consisting of a transient spike followed by a second sustained response. The biphasic response was almost abolished by removing ambient Cl−. Preloading the tissues witha cell-permeant Ca2+ chelator, 1,2-bis(2-aminophenoxy) eth-ane-N,N,N′,N′,-tetraacetic acid acetoxymethyl ester (BAPTA/AM), or pretreating them with thapsigargin (Tg), a microsomal adenosine triphosphatase inhibitor abolished the initial spike in the Isc response to NA, but had little effect on the second component. Pretreating the tissues with a non-selective β-antagonist, nadolol, reduced the second Isc response in a dose-dependent fashion but the initial spike was not affected. Microfluorimetric studies showed that NA (100 μmol · l−1) elicited single Ca2+ spikes in isolated epididymal cells, which could be abolished by prior treatment with Tg. Biochemical assays showed that NA (10 μmol · l−1) increased intracellular cyclic adenosine monophosphate concentration ([cAMP]i) and the response was abolished by prior treatment with nadolol (50 μmol · l−1). The results showed that NA elicited a biphasic Isc response mediated by a rise in intracellular Ca2+ concentration ([Ca2+]i) followed by a rise in [cAMP]i. The Ca2+-mediated Isc response had a faster onset and more transient action than the cAMP counterpart. It is suggested that NA released from noradrenergic nerve endings regulates transepithelial Cl− secretion in the epididymis thereby providing the specialized millieu vital for sperm storage and maturation. More... »

PAGES

396-401

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00388302

DOI

http://dx.doi.org/10.1007/bf00388302

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1023160943

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/8015889


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