Intramitochondrial ATP and cell functions View Full Text


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Article Info

DATE

1978-01

AUTHORS

Julius Šubík, Gizela Takácsová, Ladislav Kováč

ABSTRACT

Cells of Saccharomyces cerevisiae were depleted of intramitochondrial ATP by growing on a glucose-containing medium in the presence of antimycin A and bogkrekic acid. Antimycin A prevented ATP synthesis inside mitochondria by oxidative phosphorylation and bongkrekic acid inhibited import of glycol ytically-produced ATP from the cytosol into mitochondria. Growth of the cells containing ATP depleted mitochondria was accompanied by the following eventsMitochondrial genes were being continually lost from growing cells. The loss was random independently of whether the genes were located in the polar or the non-polar regions of the mitochondrial genome.The growing cells were being continuously converted into cytoplasmic respiration-deficient (petite) mutants. The number of mutants was raising rapidly and could be expressed as a power function of the total number of cells.Most of the ensuing petite mutants retained some of their mitochondrial genetic markers and suppressed the respiration-competent genotype in diploids which had been formed in crosses of the mutants with wild-type strains. This indicates that the mutants contained mitochondrial DNA and could not be produced as a suit of a simple dilution of mitochondrial DNA out of the cells lacking intramitochondrial ATP.When the growing cells lacking intramitochondrial ATP were crossed to strains which had not been energy-depleted transmission of mitochondrial genes from the depleted cells and frequency of recombinants were generally diminishing in accord with the assumption that the shortage in intramitochondrial energy led to decrease in input of mitochondrial alleles into the common mating pool.No respiration-deficient mutants were formed in culture of cells lacking intramitochondrial ATP under non-growing conditions.The events may be accounted for as a reaction of mitochondria to starvation for an energy source consisting in multiple random excisions of genes from the complete genophore in the form of elements that could spread away, replicate and reinsert into other genophores. The process may be considered as a remnant of an adaptive response of a common gene pool to a situation of emergency. More... »

PAGES

103-116

References to SciGraph publications

  • 1977-01. Site-specific recombination in “petite colony” mutants of Saccharomyces cerevisiae in MOLECULAR GENETICS AND GENOMICS
  • 1975-12. Biogenesis of mitochondria in MOLECULAR GENETICS AND GENOMICS
  • 1975-03. Mitochondrial genetics X: Effects of UV irradiation on transmission and recombination of mitochondrial genes in Saccharomyces cerevisiae in MOLECULAR GENETICS AND GENOMICS
  • 1977-01. On the formation of ρ−petites in yeast in MOLECULAR GENETICS AND GENOMICS
  • 1967. Antimycin A in ANTIBIOTICS
  • 1977-07. Transposable genetic elements as agents of gene instability and chromosomal rearrangements in NATURE
  • 1976-01. Mitochondrial genetics in MOLECULAR GENETICS AND GENOMICS
  • 1977-01. Comparative studies of the effects of acridines and other petite inducing drugs on the mitochondrial genome ofSaccharomyces cerevisiae in MOLECULAR GENETICS AND GENOMICS
  • 1977-02. Genetic determination of the mitochondrial adenine nucleotide translocation system and ITS role in the eukaryotic cell in MOLECULAR AND CELLULAR BIOCHEMISTRY
  • 1976-01. Mapping of mitochondrial genes in Saccharomyces cerevisiae in MOLECULAR GENETICS AND GENOMICS
  • 1974-09. Physical and genetic organization of petite and grande yeast mitochondrial DNA in MOLECULAR GENETICS AND GENOMICS
  • 1971-10. Mitochondrial DNA and suppressiveness of petite mutants in Saccharomyces cerevisiae in BIOCHEMICAL GENETICS
  • 1973-12. Induction of respiration deficient mutants in Saccharomyces cerevisiae by Berenil in MOLECULAR GENETICS AND GENOMICS
  • 1978-01. Genetic determination of ubiquinol-cytochromec reductase in MOLECULAR GENETICS AND GENOMICS
  • 1971-09. Induction of the cytoplasmic petite mutation in Saccharomyces cerevisiae by the antibacterial antibiotics erythromycin and chloramphenicol in MOLECULAR GENETICS AND GENOMICS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/bf00379735

    DOI

    http://dx.doi.org/10.1007/bf00379735

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1021344070

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/368566


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