A DR3-related DXα gene polymorphism strongly associates with insulin-dependent diabetes mellitus View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1986-01

AUTHORS

G. A. Hitman, J. Sachs, P. Cassell, J. Awad, G. F. Bottazzo, A. C. Tarn, G. Schwartz, J. P. Monson, H. Festenstein

ABSTRACT

HLA-DQ alpha and HLA-DX alpha gene polymorphisms were analyzed by Southern blot techniques in 78 Caucasoid insulin-dependent diabetes mellitus (IDDM) subjects and 55 control subjects. Five restriction fragment length polymorphisms of the HLA-DQ alpha gene correlated with HLA-DR typing. Two allelic DX alpha-related gene fragments, of 2.1 kb (U) and 1.9 kb (L) in size were identified. Genotype frequencies in the IDDM group for UU, UL, and LL were 54%, 38.5%, and 7.5%, respectively, whereas the corresponding frequencies in the control group were 24%, 40%, and 36% (P less than 0.00005 for differences in genotype frequencies). The U allele was associated particularly with IDDM patients who were DR3, with healthy controls who were DR3, as well as with IDDM patients who were not DR3. Thus, if this DX alpha U allele is not the DR3-associated IDDM susceptibility gene, it is the closest marker hitherto studied. More... »

PAGES

47-51

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00376521

DOI

http://dx.doi.org/10.1007/bf00376521

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1015580892

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/3002976


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