Prolonged exercise reduces Ca2+ release in rat skeletal muscle sarcoplasmic reticulum View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1993-02

AUTHORS

Terence G. Favero, Isaac N. Pessah, Gary A. Klug

ABSTRACT

Prolonged exercise decreased the rate of Ca+ release in sarcoplasmic reticulum (SR) vesicles isolated from rat muscle by 20-30% when release was initiated by 5, 10, and 20 microM AgNO3 [3H]Ryanodine binding was also depressed by 20% in SR vesicles isolated from the exercised animals. In contrast, the maximum amount of Ca2+ release in the presence of ruthenium red, a known inhibitor of the Ca2+ release mechanism, was not affected by prolonged exercise. These results suggest that exercise depressed Ca2+ release from SR by directly modifying the Ca2+ release channel. More... »

PAGES

472-475

References to SciGraph publications

  • 1989-04. Critical sulfhydryls regulate calcium release from sarcoplasmic reticulum in JOURNAL OF BIOENERGETICS AND BIOMEMBRANES
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/bf00375074

    DOI

    http://dx.doi.org/10.1007/bf00375074

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1036600524

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/7682687


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