Specific immune responses after booster immunization with tetanus toxoid in man: Study of kinetics, family segregation, and linkage to HLA ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1983-10

AUTHORS

J. J. Ballet, C. Rabian-Herzog, M. Lathrop, J. -F. Bourge, M. Agrapart, J. Drouet, J. -M. Lalouel, J. Dausset

ABSTRACT

Kinetics and family transmission of antigen-specific in vitro cell-mediated responses were investigated in 68, and serum-antibody responses to tetanus toxoid (TT) in 73 individuals from a total of 12 families. Proliferative responses to highly purified TT monomer were studied in 6- to 7-day lymphocyte cultures. The effect of booster immunization was detectable 7 (D7) and 30 (D30), but not 120 days (D120) later. The sex of donors was not found to have any influence. A significant influence of the time interval since the last immunization was found for the responses at D7 and D30. Data were correspondingly adjusted for segregation and linkage analyses. Several transmission hypotheses for the data obtained at D7 and D30 were evaluated by likelihood ratio tests. Observations at D30 were compatible with the hypothesis of a control by a dominant genetic determinant for high responses closely linked to the major histocompatibility complex region. No such evidence could be found for D7. After booster immunization, mean antibody levels determined on D7, D30 (peak of response), and D120 were found to be higher than those prior to immunization (D0). The sex of the donors was found to have no influence on antibody responses. The time interval since the last immunization and the age of donors both had a slight influence, and data were correspondingly adjusted for segregation and linkage analyses, which showed no evidence of genetic control of the antibody responses or of linkage to HLA. More... »

PAGES

343-358

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00372467

DOI

http://dx.doi.org/10.1007/bf00372467

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1011276274

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/6629440


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Immunology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adolescent", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antibody Formation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antigen-Antibody Complex", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Child", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genes, Dominant", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genes, Recessive", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genetic Linkage", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "HLA Antigens", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunization, Secondary", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Kinetics", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lymphocyte Activation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lymphocytes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Major Histocompatibility Complex", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tetanus Toxoid", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "H\u00f4pital Saint-Louis", 
          "id": "https://www.grid.ac/institutes/grid.413328.f", 
          "name": [
            "Laboratoire d'Immunochimie et d'Immunopathologie (INSERM U 108), H\u00f4pital Saint-Louis, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ballet", 
        "givenName": "J. J.", 
        "id": "sg:person.01167405116.77", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01167405116.77"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "H\u00f4pital Saint-Louis", 
          "id": "https://www.grid.ac/institutes/grid.413328.f", 
          "name": [
            "Unit\u00e9 de Recherches d'Immunog\u00e9n\u00e9tique de la Transplantation humaine (INSERM U 93) (Research Institute on Blood Diseases and Laboratory of Oncology and Immunohematology of CRNS), H\u00f4pital Saint-Louis, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rabian-Herzog", 
        "givenName": "C.", 
        "id": "sg:person.01336033013.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01336033013.47"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Paris Diderot University", 
          "id": "https://www.grid.ac/institutes/grid.7452.4", 
          "name": [
            "Laboratoire d'Anthropologie, Mus\u00e9e de l'Homme, and Laboratoire d'Anthropologie, Universit\u00e9 Paris VII, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lathrop", 
        "givenName": "M.", 
        "id": "sg:person.01132647725.77", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01132647725.77"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "H\u00f4pital Saint-Louis", 
          "id": "https://www.grid.ac/institutes/grid.413328.f", 
          "name": [
            "Unit\u00e9 de Recherches d'Immunog\u00e9n\u00e9tique de la Transplantation humaine (INSERM U 93) (Research Institute on Blood Diseases and Laboratory of Oncology and Immunohematology of CRNS), H\u00f4pital Saint-Louis, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bourge", 
        "givenName": "J. -F.", 
        "id": "sg:person.01300575136.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01300575136.18"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "H\u00f4pital Saint-Louis", 
          "id": "https://www.grid.ac/institutes/grid.413328.f", 
          "name": [
            "Laboratoire d'Immunochimie et d'Immunopathologie (INSERM U 108), H\u00f4pital Saint-Louis, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Agrapart", 
        "givenName": "M.", 
        "id": "sg:person.0100621157.61", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0100621157.61"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Minist\u00e8re des Affaires sociales et de la Sant\u00e9", 
          "id": "https://www.grid.ac/institutes/grid.418199.c", 
          "name": [
            "Centre National de Transfusion Sanguine, Orsay, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Drouet", 
        "givenName": "J.", 
        "id": "sg:person.073663026.81", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.073663026.81"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Paris Diderot University", 
          "id": "https://www.grid.ac/institutes/grid.7452.4", 
          "name": [
            "Laboratoire d'Anthropologie, Mus\u00e9e de l'Homme, and Laboratoire d'Anthropologie, Universit\u00e9 Paris VII, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lalouel", 
        "givenName": "J. -M.", 
        "id": "sg:person.0105106220.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0105106220.18"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "H\u00f4pital Saint-Louis", 
          "id": "https://www.grid.ac/institutes/grid.413328.f", 
          "name": [
            "Unit\u00e9 de Recherches d'Immunog\u00e9n\u00e9tique de la Transplantation humaine (INSERM U 93) (Research Institute on Blood Diseases and Laboratory of Oncology and Immunohematology of CRNS), H\u00f4pital Saint-Louis, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dausset", 
        "givenName": "J.", 
        "id": "sg:person.013525213657.60", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013525213657.60"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/272359b0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000344645", 
          "https://doi.org/10.1038/272359b0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.78.3.1858", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014617138"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0009-8981(70)90344-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014785617"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0009-8981(70)90344-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014785617"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/302067a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015473712", 
          "https://doi.org/10.1038/302067a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm197709292971303", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017530002"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-1-4684-3761-4_10", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020444986", 
          "https://doi.org/10.1007/978-1-4684-3761-4_10"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1399-0039.1980.tb00319.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022634484"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/eji.1830121010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032085603"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm197601012940104", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032328787"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.141.5.935", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036058344"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00372105", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039122005", 
          "https://doi.org/10.1007/bf00372105"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00372105", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039122005", 
          "https://doi.org/10.1007/bf00372105"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-197805000-00012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040793046"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-197805000-00012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040793046"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000152448", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041243572"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.150.2.246", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045428547"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1600-065x.1975.tb01554.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049218765"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000153231", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049560719"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01567780", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053041268", 
          "https://doi.org/10.1007/bf01567780"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2307/2529760", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1069975374"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1080024366", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1080630303", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1080787212", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1081750166", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082077058", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082093553", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082106547", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082854837", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1983-10", 
    "datePublishedReg": "1983-10-01", 
    "description": "Kinetics and family transmission of antigen-specific in vitro cell-mediated responses were investigated in 68, and serum-antibody responses to tetanus toxoid (TT) in 73 individuals from a total of 12 families. Proliferative responses to highly purified TT monomer were studied in 6- to 7-day lymphocyte cultures. The effect of booster immunization was detectable 7 (D7) and 30 (D30), but not 120 days (D120) later. The sex of donors was not found to have any influence. A significant influence of the time interval since the last immunization was found for the responses at D7 and D30. Data were correspondingly adjusted for segregation and linkage analyses. Several transmission hypotheses for the data obtained at D7 and D30 were evaluated by likelihood ratio tests. Observations at D30 were compatible with the hypothesis of a control by a dominant genetic determinant for high responses closely linked to the major histocompatibility complex region. No such evidence could be found for D7. After booster immunization, mean antibody levels determined on D7, D30 (peak of response), and D120 were found to be higher than those prior to immunization (D0). The sex of the donors was found to have no influence on antibody responses. The time interval since the last immunization and the age of donors both had a slight influence, and data were correspondingly adjusted for segregation and linkage analyses, which showed no evidence of genetic control of the antibody responses or of linkage to HLA.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/bf00372467", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1019755", 
        "issn": [
          "0093-7711", 
          "1432-1211"
        ], 
        "name": "Immunogenetics", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "4", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "18"
      }
    ], 
    "name": "Specific immune responses after booster immunization with tetanus toxoid in man: Study of kinetics, family segregation, and linkage to HLA of in vitro lymphocyte proliferative responses and serum-antibody responses", 
    "pagination": "343-358", 
    "productId": [
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/bf00372467"
        ]
      }, 
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "35b99ba9699b5ca6fd02bc45b3437c6a6575248679ac40cbed998018c9e5d99f"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1011276274"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0420404"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "6629440"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/bf00372467", 
      "https://app.dimensions.ai/details/publication/pub.1011276274"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-15T08:51", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000374_0000000374/records_119741_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007/BF00372467"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/bf00372467'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/bf00372467'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/bf00372467'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/bf00372467'


 

This table displays all metadata directly associated to this object as RDF triples.

276 TRIPLES      21 PREDICATES      74 URIs      40 LITERALS      28 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/bf00372467 schema:about N07de02e37dc74c9e9256c92aabac78d0
2 N0be1494d97a64f03adb5361da7c65dc6
3 N0dd05c955afb4865a7af49fe0239d45f
4 N0e6bfadc35544ef197d015a485181b00
5 N1e3546004d86469691490bf7dbc23e16
6 N3a0e6f3f049342718847f8ba85ce92e0
7 N448c9f75cf1f49e09fcfb846528f34a4
8 N4cb1f90e16134757a385a554a37cb5b6
9 N5320405e43834ab88c713e99c23a14db
10 N62e8805deab447168f4dbc58550d1b80
11 N6527c2da620f4c8a8dbad323b666d4fb
12 N808a4a2dc2854df089fa1b7f99648523
13 N8eb7262c00f140a2903bf482e3db6b8d
14 N911a6f61406947448cd9d42000e52f2d
15 Na0ce5ae032c5445c81fbe0b927c8e38c
16 Naae4c94c4b3641cfadda4956dc671a2a
17 Nb4fa06d3a4fe4de29839f6abc46be3f4
18 Nd3b5f9877a1a47bc86672f428287d888
19 Nef190d003c7d410f993ccc0b9e99ab07
20 anzsrc-for:11
21 anzsrc-for:1107
22 schema:author N8b5a17fb79354ef0895fe0b61d309a08
23 schema:citation sg:pub.10.1007/978-1-4684-3761-4_10
24 sg:pub.10.1007/bf00372105
25 sg:pub.10.1007/bf01567780
26 sg:pub.10.1038/272359b0
27 sg:pub.10.1038/302067a0
28 https://app.dimensions.ai/details/publication/pub.1080024366
29 https://app.dimensions.ai/details/publication/pub.1080630303
30 https://app.dimensions.ai/details/publication/pub.1080787212
31 https://app.dimensions.ai/details/publication/pub.1081750166
32 https://app.dimensions.ai/details/publication/pub.1082077058
33 https://app.dimensions.ai/details/publication/pub.1082093553
34 https://app.dimensions.ai/details/publication/pub.1082106547
35 https://app.dimensions.ai/details/publication/pub.1082854837
36 https://doi.org/10.1002/eji.1830121010
37 https://doi.org/10.1016/0009-8981(70)90344-x
38 https://doi.org/10.1056/nejm197601012940104
39 https://doi.org/10.1056/nejm197709292971303
40 https://doi.org/10.1073/pnas.78.3.1858
41 https://doi.org/10.1084/jem.141.5.935
42 https://doi.org/10.1084/jem.150.2.246
43 https://doi.org/10.1097/00007890-197805000-00012
44 https://doi.org/10.1111/j.1399-0039.1980.tb00319.x
45 https://doi.org/10.1111/j.1600-065x.1975.tb01554.x
46 https://doi.org/10.1159/000152448
47 https://doi.org/10.1159/000153231
48 https://doi.org/10.2307/2529760
49 schema:datePublished 1983-10
50 schema:datePublishedReg 1983-10-01
51 schema:description Kinetics and family transmission of antigen-specific in vitro cell-mediated responses were investigated in 68, and serum-antibody responses to tetanus toxoid (TT) in 73 individuals from a total of 12 families. Proliferative responses to highly purified TT monomer were studied in 6- to 7-day lymphocyte cultures. The effect of booster immunization was detectable 7 (D7) and 30 (D30), but not 120 days (D120) later. The sex of donors was not found to have any influence. A significant influence of the time interval since the last immunization was found for the responses at D7 and D30. Data were correspondingly adjusted for segregation and linkage analyses. Several transmission hypotheses for the data obtained at D7 and D30 were evaluated by likelihood ratio tests. Observations at D30 were compatible with the hypothesis of a control by a dominant genetic determinant for high responses closely linked to the major histocompatibility complex region. No such evidence could be found for D7. After booster immunization, mean antibody levels determined on D7, D30 (peak of response), and D120 were found to be higher than those prior to immunization (D0). The sex of the donors was found to have no influence on antibody responses. The time interval since the last immunization and the age of donors both had a slight influence, and data were correspondingly adjusted for segregation and linkage analyses, which showed no evidence of genetic control of the antibody responses or of linkage to HLA.
52 schema:genre research_article
53 schema:inLanguage en
54 schema:isAccessibleForFree false
55 schema:isPartOf N369c435833f1464e9002c49072e96095
56 N76ea10467e364f1da0febd7c6aab2288
57 sg:journal.1019755
58 schema:name Specific immune responses after booster immunization with tetanus toxoid in man: Study of kinetics, family segregation, and linkage to HLA of in vitro lymphocyte proliferative responses and serum-antibody responses
59 schema:pagination 343-358
60 schema:productId N1ed42a6235224e68909dc8f51f29de69
61 N21a426c4822347a3ad230e548946d27f
62 N58f64307c5a34750881280d183ce394d
63 N8bb23441634648d2b17355a3f85f4b34
64 Nb50b1fa60917440e92e8857f02fb4b78
65 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011276274
66 https://doi.org/10.1007/bf00372467
67 schema:sdDatePublished 2019-04-15T08:51
68 schema:sdLicense https://scigraph.springernature.com/explorer/license/
69 schema:sdPublisher Nd4002b8a4aa54e0684fae6f5b154ff43
70 schema:url http://link.springer.com/10.1007/BF00372467
71 sgo:license sg:explorer/license/
72 sgo:sdDataset articles
73 rdf:type schema:ScholarlyArticle
74 N07de02e37dc74c9e9256c92aabac78d0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
75 schema:name Female
76 rdf:type schema:DefinedTerm
77 N0be1494d97a64f03adb5361da7c65dc6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
78 schema:name Humans
79 rdf:type schema:DefinedTerm
80 N0dd05c955afb4865a7af49fe0239d45f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
81 schema:name Male
82 rdf:type schema:DefinedTerm
83 N0e6bfadc35544ef197d015a485181b00 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
84 schema:name Genes, Dominant
85 rdf:type schema:DefinedTerm
86 N1e3546004d86469691490bf7dbc23e16 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
87 schema:name Tetanus Toxoid
88 rdf:type schema:DefinedTerm
89 N1ed42a6235224e68909dc8f51f29de69 schema:name nlm_unique_id
90 schema:value 0420404
91 rdf:type schema:PropertyValue
92 N21a426c4822347a3ad230e548946d27f schema:name pubmed_id
93 schema:value 6629440
94 rdf:type schema:PropertyValue
95 N369c435833f1464e9002c49072e96095 schema:volumeNumber 18
96 rdf:type schema:PublicationVolume
97 N3a0e6f3f049342718847f8ba85ce92e0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
98 schema:name Middle Aged
99 rdf:type schema:DefinedTerm
100 N40c0fdb9a6c74f5baf8dd9d59667a994 rdf:first sg:person.0105106220.18
101 rdf:rest N4ba1cfe0342648ab8c45ce4fb3152ec8
102 N448c9f75cf1f49e09fcfb846528f34a4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Genes, Recessive
104 rdf:type schema:DefinedTerm
105 N4ba1cfe0342648ab8c45ce4fb3152ec8 rdf:first sg:person.013525213657.60
106 rdf:rest rdf:nil
107 N4cb1f90e16134757a385a554a37cb5b6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Antigen-Antibody Complex
109 rdf:type schema:DefinedTerm
110 N5320405e43834ab88c713e99c23a14db schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name Antibody Formation
112 rdf:type schema:DefinedTerm
113 N58f64307c5a34750881280d183ce394d schema:name dimensions_id
114 schema:value pub.1011276274
115 rdf:type schema:PropertyValue
116 N60762b91fe9645b0a60cb48efdc04e81 rdf:first sg:person.01132647725.77
117 rdf:rest N9f7e2c6d6ecc4d70bf1bd26b0525b13f
118 N62e8805deab447168f4dbc58550d1b80 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Immunization, Secondary
120 rdf:type schema:DefinedTerm
121 N6527c2da620f4c8a8dbad323b666d4fb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Adolescent
123 rdf:type schema:DefinedTerm
124 N6b7750f529c74c9a9f93dd6c01ba0c59 rdf:first sg:person.01336033013.47
125 rdf:rest N60762b91fe9645b0a60cb48efdc04e81
126 N76ea10467e364f1da0febd7c6aab2288 schema:issueNumber 4
127 rdf:type schema:PublicationIssue
128 N808a4a2dc2854df089fa1b7f99648523 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name HLA Antigens
130 rdf:type schema:DefinedTerm
131 N8b5a17fb79354ef0895fe0b61d309a08 rdf:first sg:person.01167405116.77
132 rdf:rest N6b7750f529c74c9a9f93dd6c01ba0c59
133 N8bb23441634648d2b17355a3f85f4b34 schema:name readcube_id
134 schema:value 35b99ba9699b5ca6fd02bc45b3437c6a6575248679ac40cbed998018c9e5d99f
135 rdf:type schema:PropertyValue
136 N8eb7262c00f140a2903bf482e3db6b8d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Kinetics
138 rdf:type schema:DefinedTerm
139 N911a6f61406947448cd9d42000e52f2d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Genetic Linkage
141 rdf:type schema:DefinedTerm
142 N9f7e2c6d6ecc4d70bf1bd26b0525b13f rdf:first sg:person.01300575136.18
143 rdf:rest Nbf6f82edcc174e399a5672e612dad306
144 Na0ce5ae032c5445c81fbe0b927c8e38c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Major Histocompatibility Complex
146 rdf:type schema:DefinedTerm
147 Naae4c94c4b3641cfadda4956dc671a2a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Lymphocyte Activation
149 rdf:type schema:DefinedTerm
150 Nb4fa06d3a4fe4de29839f6abc46be3f4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Child
152 rdf:type schema:DefinedTerm
153 Nb50b1fa60917440e92e8857f02fb4b78 schema:name doi
154 schema:value 10.1007/bf00372467
155 rdf:type schema:PropertyValue
156 Nb6381560ded94520bdaff68f97c3846f rdf:first sg:person.073663026.81
157 rdf:rest N40c0fdb9a6c74f5baf8dd9d59667a994
158 Nbf6f82edcc174e399a5672e612dad306 rdf:first sg:person.0100621157.61
159 rdf:rest Nb6381560ded94520bdaff68f97c3846f
160 Nd3b5f9877a1a47bc86672f428287d888 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
161 schema:name Lymphocytes
162 rdf:type schema:DefinedTerm
163 Nd4002b8a4aa54e0684fae6f5b154ff43 schema:name Springer Nature - SN SciGraph project
164 rdf:type schema:Organization
165 Nef190d003c7d410f993ccc0b9e99ab07 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Adult
167 rdf:type schema:DefinedTerm
168 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
169 schema:name Medical and Health Sciences
170 rdf:type schema:DefinedTerm
171 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
172 schema:name Immunology
173 rdf:type schema:DefinedTerm
174 sg:journal.1019755 schema:issn 0093-7711
175 1432-1211
176 schema:name Immunogenetics
177 rdf:type schema:Periodical
178 sg:person.0100621157.61 schema:affiliation https://www.grid.ac/institutes/grid.413328.f
179 schema:familyName Agrapart
180 schema:givenName M.
181 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0100621157.61
182 rdf:type schema:Person
183 sg:person.0105106220.18 schema:affiliation https://www.grid.ac/institutes/grid.7452.4
184 schema:familyName Lalouel
185 schema:givenName J. -M.
186 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0105106220.18
187 rdf:type schema:Person
188 sg:person.01132647725.77 schema:affiliation https://www.grid.ac/institutes/grid.7452.4
189 schema:familyName Lathrop
190 schema:givenName M.
191 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01132647725.77
192 rdf:type schema:Person
193 sg:person.01167405116.77 schema:affiliation https://www.grid.ac/institutes/grid.413328.f
194 schema:familyName Ballet
195 schema:givenName J. J.
196 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01167405116.77
197 rdf:type schema:Person
198 sg:person.01300575136.18 schema:affiliation https://www.grid.ac/institutes/grid.413328.f
199 schema:familyName Bourge
200 schema:givenName J. -F.
201 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01300575136.18
202 rdf:type schema:Person
203 sg:person.01336033013.47 schema:affiliation https://www.grid.ac/institutes/grid.413328.f
204 schema:familyName Rabian-Herzog
205 schema:givenName C.
206 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01336033013.47
207 rdf:type schema:Person
208 sg:person.013525213657.60 schema:affiliation https://www.grid.ac/institutes/grid.413328.f
209 schema:familyName Dausset
210 schema:givenName J.
211 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013525213657.60
212 rdf:type schema:Person
213 sg:person.073663026.81 schema:affiliation https://www.grid.ac/institutes/grid.418199.c
214 schema:familyName Drouet
215 schema:givenName J.
216 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.073663026.81
217 rdf:type schema:Person
218 sg:pub.10.1007/978-1-4684-3761-4_10 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020444986
219 https://doi.org/10.1007/978-1-4684-3761-4_10
220 rdf:type schema:CreativeWork
221 sg:pub.10.1007/bf00372105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039122005
222 https://doi.org/10.1007/bf00372105
223 rdf:type schema:CreativeWork
224 sg:pub.10.1007/bf01567780 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053041268
225 https://doi.org/10.1007/bf01567780
226 rdf:type schema:CreativeWork
227 sg:pub.10.1038/272359b0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000344645
228 https://doi.org/10.1038/272359b0
229 rdf:type schema:CreativeWork
230 sg:pub.10.1038/302067a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015473712
231 https://doi.org/10.1038/302067a0
232 rdf:type schema:CreativeWork
233 https://app.dimensions.ai/details/publication/pub.1080024366 schema:CreativeWork
234 https://app.dimensions.ai/details/publication/pub.1080630303 schema:CreativeWork
235 https://app.dimensions.ai/details/publication/pub.1080787212 schema:CreativeWork
236 https://app.dimensions.ai/details/publication/pub.1081750166 schema:CreativeWork
237 https://app.dimensions.ai/details/publication/pub.1082077058 schema:CreativeWork
238 https://app.dimensions.ai/details/publication/pub.1082093553 schema:CreativeWork
239 https://app.dimensions.ai/details/publication/pub.1082106547 schema:CreativeWork
240 https://app.dimensions.ai/details/publication/pub.1082854837 schema:CreativeWork
241 https://doi.org/10.1002/eji.1830121010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032085603
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1016/0009-8981(70)90344-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1014785617
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1056/nejm197601012940104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032328787
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1056/nejm197709292971303 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017530002
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1073/pnas.78.3.1858 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014617138
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1084/jem.141.5.935 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036058344
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1084/jem.150.2.246 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045428547
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1097/00007890-197805000-00012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040793046
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1111/j.1399-0039.1980.tb00319.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1022634484
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1111/j.1600-065x.1975.tb01554.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1049218765
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1159/000152448 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041243572
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1159/000153231 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049560719
264 rdf:type schema:CreativeWork
265 https://doi.org/10.2307/2529760 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069975374
266 rdf:type schema:CreativeWork
267 https://www.grid.ac/institutes/grid.413328.f schema:alternateName Hôpital Saint-Louis
268 schema:name Laboratoire d'Immunochimie et d'Immunopathologie (INSERM U 108), Hôpital Saint-Louis, Paris, France
269 Unité de Recherches d'Immunogénétique de la Transplantation humaine (INSERM U 93) (Research Institute on Blood Diseases and Laboratory of Oncology and Immunohematology of CRNS), Hôpital Saint-Louis, Paris, France
270 rdf:type schema:Organization
271 https://www.grid.ac/institutes/grid.418199.c schema:alternateName Ministère des Affaires sociales et de la Santé
272 schema:name Centre National de Transfusion Sanguine, Orsay, France
273 rdf:type schema:Organization
274 https://www.grid.ac/institutes/grid.7452.4 schema:alternateName Paris Diderot University
275 schema:name Laboratoire d'Anthropologie, Musée de l'Homme, and Laboratoire d'Anthropologie, Université Paris VII, Paris, France
276 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...