Evidence for distinct polygenic regulation of antibody responses to some unrelated antigens in lines of mice selected for high or ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1982-12

AUTHORS

Wafa H. Cabrera, Olga M. Ibanez, Silvio L. Oliveira, Osvaldo A. Sant'Anna, Maria Siqueira, Denise Mouton, Guido Biozzi

ABSTRACT

The effect of the selective breeding of mice for high or low antibody production to complex immunogens is largely “nonspecific”, since it modifies the responsiveness of high (H) and low (L) lines to many antigens unrelated to the selection antigen. However, the nonspecific effect of the polygenic control operating in these lines is not a general feature. For example, the group of genes in selection IV, carried out for responsiveness to somatic antigen of Salmonella, does not modify the responses to sheep erythrocytes (SE). Despite equivalent responses in H and L mice of selection IV, a large variability was found in individual responses of F2 interline hybrids, which demonstrates the presence of alleles with high or low effect on responses to SE. A selective breeding (Selection IV-A) was therefore initiated from this F2 population for responsiveness to SE. A progressive interline divergence occurred during the first seven generations of selection; the interline separation was due to polygenic regulation (about four independent loci from a preliminary estimate).Equivalent responses to the s antigen of Salmonella are observed in the two lines. This constitutes additional evidence for distinct polygenic regulation of responses to SE and to somatic antigen. Moreover, the pattern of responses to several unrelated antigens (nonspecific effect) also differs between Selections IV and IV-A. More... »

PAGES

583-592

References to SciGraph publications

  • 1979. Genetics of Immunoresponsiveness to Natural Antigens in the Mouse in CURRENT TOPICS IN MICROBIOLOGY AND IMMUNOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/bf00372027

    DOI

    http://dx.doi.org/10.1007/bf00372027

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1041308412

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/6763916


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