Epidermal growth factor and transferrin receptor expression in human embryonic and fetal epidermal cells View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1990-12

AUTHORS

G. Zambruno, G. Girolomoni, V. Manca, A. Segre, A. Giannetti

ABSTRACT

Epidermal growth factor receptors (EGFR) and transferrin receptors (TFR) are known to be involved in cell proliferation and to be expressed in normal human epidermis. To date little is known about EGFR and TRF expression in human skin during embryonic and fetal development. In the present work, we studied skin specimens from 30 aborted embryos and fetuses ranging from 7 to 31 weeks estimated gestational age. Monoclonal antibodies to EGFR and TFR were applied on frozen skin sections using an amplification biotin-streptavidin-fluorescein technique. TFR was faintly expressed on epidermal basal cells throughout embryonic and fetal development, as it is in adult epidermis. Up to week 12, EGFR was uniformly expressed on cells of the basal, intermediate and periderm cell layers. From the midfetal period onwards, the suprabasal cell layers showed a decreased staining compared with the basal layer. During the third trimester the cornified cell layer was completely negative. The hair germ and heir peg cells were positive. Later, the outer root sheath and hair bulb remained labelled, with less staining of the hair cone. The sebaceous and eccrine sweat glands were also labelled. These results suggest that in embryonic and fetal epidermis, TFR expression is not correlated with cellular proliferation, whereas EGFR appear to be associated with proliferating and undifferentiated cells. More... »

PAGES

544-548

References to SciGraph publications

  • 1988-07. Phenotypic expression of human epidermal growth factor in foetal submandibular gland and pleomorphic adenoma of salivary gland in VIRCHOWS ARCHIV A PATHOLOGICAL ANATOMY AND HISTOPATHOLOGY
  • 1987-08. Production and auto-induction of transforming growth factor-α in human keratinocytes in NATURE
  • 1974-10. Effect of foetal calf serum and epidermal growth factor on DNA synthesis in explants of chick embryo epidermis in NATURE
  • 1977-02. Epidermal growth factor and the multiplication of cultured human epidermal keratinocytes in NATURE
  • 1987-01. Label-Retaining Cells in Human Embryonic and Fetal Epidermis in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 1988-10. Epidermal growth factor receptor expression in human foetal tissues is age-dependent in BRITISH JOURNAL OF CANCER
  • 1984. Monoclonal Antibodies to Transferrin Receptors in MONOCLONAL ANTIBODIES TO RECEPTORS
  • 1984-02. Visualization of Epidermal Growth Factor Receptors in Human Epidermis in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 1979-02. Effect of Epidermal Growth Factor on Lung Maturation in Fetal Rabbits in PEDIATRIC RESEARCH
  • 1984-08. Distribution of Epidermal Growth Factor Receptors in Rat Tissues During Embryonic Skin Development, Hair Formation, and the Adult Hair Growth Cycle in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 1987-09. Identification of Somatomedin/Insulin-Like Growth Factor Immunoreactive Cells in the Human Fetus in PEDIATRIC RESEARCH
  • 1985-09. Differences in Human Skin Between the Epidermal Growth Factor Receptor Distribution Detected by EGF Binding and Monoclonal Antibody Recognition in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/bf00371951

    DOI

    http://dx.doi.org/10.1007/bf00371951

    DIMENSIONS

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    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/2082838


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