Cloning and characterization of human phosphatase inhibitor-2 (IPP-2) sequences View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1994-08

AUTHORS

P. Sanséau, A. Jackson, R. P. Alderton, S. Beck, G. Senger, D. Sheer, A. Kelly, J. Trowsdale

ABSTRACT

cDNA clones similar to rabbit muscle phosphatase inhibitor-2 (IPP-2) were isolated from human libraries. On Northern blots two transcripts of approximately 2kbp and approximately 4kbp were detected in all tissues tested. Analysis of cDNA sequences showed that the longer transcripts were similar to the shorter clones but contained extended 3' ends. The human nucleotide sequence was highly homologous (94% identity) to the rabbit IPP-2 sequence and encoded a peptide of 205 amino acids. IPP-2 sequences were highly conserved throughout vertebrates. Southern hybridization results were consistent with the existence of a family of related IPP-2 sequences in the human genome. Most of these are likely to be pseudogenes, since all of the cDNA clones examined could have originated from a single gene. By in situ hybridization IPP-2 sequences were mapped to several different human chromosomes. We sequenced one gene located in the major histocompatibility complex (MHC) on Chromosome (Chr) 6 that contained the entire coding region of IPP-2. More... »

PAGES

490-496

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00369318

DOI

http://dx.doi.org/10.1007/bf00369318

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1021948392

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/7949733


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