Polymorphism of genes involved in anti-tubular basement membrane disease in rats View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1983-01

AUTHORS

Eric G. Neilson, David L. Gasser, Eileen McCafferty, Bruce Zakheim, S. Michael Phillips

ABSTRACT

Inbred strains of rats differ widely in their susceptibility to interstitial nephritis induced by rabbit renal tubular basement membrane (TBM) preparations. We now report that susceptibility is determined in part by an RTI-linked gene for effector cell responsiveness producing interstitial lesions. Furthermore we also obtained evidence that the gene determining expression of the target TBM antigen is linked to the gene for albinism on the first linkage group. When non-susceptible rats lacking the TBM antigen but having the gene for cellular responsiveness were mated with non-susceptible rats which had the TBM antigen but lacked the gene for cellular responsiveness, the F1 hybrids were susceptible to the induction of interstitial nephritis. Although strains varied widely in the amount of anti-TBM antibody (αTBM-Ab) they produced, this variation does not appear to be controlled by RTI-linked genes, nor does the isotype or amount of antibody appear to be related to the susceptibility to infiltrating cellular lesions. More... »

PAGES

55-65

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00364289

DOI

http://dx.doi.org/10.1007/bf00364289

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1010269683

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/6826209


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Immunology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Albinism", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antibody Formation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Autoantibodies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Autoimmune Diseases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Basement Membrane", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genetic Linkage", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Kidney Tubules", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lymphocyte Activation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nephritis, Interstitial", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Renal Electrolyte Section, University of Pennsylvania School of Medicine, 19104, Philadelphia, Pennsylvania", 
          "id": "http://www.grid.ac/institutes/grid.25879.31", 
          "name": [
            "Renal Electrolyte Section, University of Pennsylvania School of Medicine, 19104, Philadelphia, Pennsylvania"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Neilson", 
        "givenName": "Eric G.", 
        "id": "sg:person.01261253004.94", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01261253004.94"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Human Genetics, University of Pennsylvania School of Medicine, 19104, Philadelphia, Pennsylvania", 
          "id": "http://www.grid.ac/institutes/grid.25879.31", 
          "name": [
            "Department of Human Genetics, University of Pennsylvania School of Medicine, 19104, Philadelphia, Pennsylvania"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gasser", 
        "givenName": "David L.", 
        "id": "sg:person.01320443624.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01320443624.18"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Renal Electrolyte Section, University of Pennsylvania School of Medicine, 19104, Philadelphia, Pennsylvania", 
          "id": "http://www.grid.ac/institutes/grid.25879.31", 
          "name": [
            "Renal Electrolyte Section, University of Pennsylvania School of Medicine, 19104, Philadelphia, Pennsylvania"
          ], 
          "type": "Organization"
        }, 
        "familyName": "McCafferty", 
        "givenName": "Eileen", 
        "id": "sg:person.0765745261.65", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0765745261.65"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Renal Electrolyte Section, University of Pennsylvania School of Medicine, 19104, Philadelphia, Pennsylvania", 
          "id": "http://www.grid.ac/institutes/grid.25879.31", 
          "name": [
            "Renal Electrolyte Section, University of Pennsylvania School of Medicine, 19104, Philadelphia, Pennsylvania"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zakheim", 
        "givenName": "Bruce", 
        "id": "sg:person.01150307061.98", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01150307061.98"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Allergy-Immunology Section, University of Pennsylvania School of Medicine, 19104, Philadelphia, Pennsylvania", 
          "id": "http://www.grid.ac/institutes/grid.25879.31", 
          "name": [
            "Allergy-Immunology Section, University of Pennsylvania School of Medicine, 19104, Philadelphia, Pennsylvania"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Phillips", 
        "givenName": "S. Michael", 
        "id": "sg:person.01056265317.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01056265317.51"
        ], 
        "type": "Person"
      }
    ], 
    "datePublished": "1983-01", 
    "datePublishedReg": "1983-01-01", 
    "description": "Inbred strains of rats differ widely in their susceptibility to interstitial nephritis induced by rabbit renal tubular basement membrane (TBM) preparations. We now report that susceptibility is determined in part by an RTI-linked gene for effector cell responsiveness producing interstitial lesions. Furthermore we also obtained evidence that the gene determining expression of the target TBM antigen is linked to the gene for albinism on the first linkage group. When non-susceptible rats lacking the TBM antigen but having the gene for cellular responsiveness were mated with non-susceptible rats which had the TBM antigen but lacked the gene for cellular responsiveness, the F1 hybrids were susceptible to the induction of interstitial nephritis. Although strains varied widely in the amount of anti-TBM antibody (\u03b1TBM-Ab) they produced, this variation does not appear to be controlled by RTI-linked genes, nor does the isotype or amount of antibody appear to be related to the susceptibility to infiltrating cellular lesions.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/bf00364289", 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2682080", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2461099", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1019755", 
        "issn": [
          "0093-7711", 
          "1432-1211"
        ], 
        "name": "Immunogenetics", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "17"
      }
    ], 
    "keywords": [
      "cellular responsiveness", 
      "TBM antigen", 
      "first linkage group", 
      "interstitial nephritis", 
      "linkage groups", 
      "anti-tubular basement membrane disease", 
      "F1 hybrids", 
      "genes", 
      "strains of rats", 
      "polymorphisms of genes", 
      "basement membrane preparation", 
      "TBM antibody", 
      "interstitial lesions", 
      "membrane disease", 
      "amount of antibody", 
      "cell responsiveness", 
      "cellular lesions", 
      "rats", 
      "membrane preparations", 
      "antigen", 
      "nephritis", 
      "lesions", 
      "responsiveness", 
      "antibodies", 
      "strains", 
      "susceptibility", 
      "expression", 
      "polymorphism", 
      "albinism", 
      "hybrids", 
      "disease", 
      "induction", 
      "isotypes", 
      "group", 
      "variation", 
      "evidence", 
      "RTI", 
      "amount", 
      "part", 
      "preparation"
    ], 
    "name": "Polymorphism of genes involved in anti-tubular basement membrane disease in rats", 
    "pagination": "55-65", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1010269683"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/bf00364289"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "6826209"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/bf00364289", 
      "https://app.dimensions.ai/details/publication/pub.1010269683"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-10-01T06:27", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221001/entities/gbq_results/article/article_178.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/bf00364289"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/bf00364289'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/bf00364289'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/bf00364289'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/bf00364289'


 

This table displays all metadata directly associated to this object as RDF triples.

181 TRIPLES      20 PREDICATES      77 URIs      69 LITERALS      18 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/bf00364289 schema:about N089cd5a22d394eca960abeb346a3d4c6
2 N1dff920cdeb24a049439519422fb57ea
3 N389b29db58164aaebea4b4507eb02790
4 N44754f49ceef41099ff76efa4195c833
5 N5457654b12a145f2ac377bc243ba7599
6 N65a1559cd1ff4560b68849c8d8e7714c
7 N8603119d1ccf4959a2a23aec365c6977
8 N9786f885fc174cf9a35c44e446784cd8
9 Na8436107b72c405a8fc2425307baf96a
10 Nedad4fa52a75422da8282666818f2154
11 Nf19db6b79fb240d98c3364e8dcb61b23
12 anzsrc-for:11
13 anzsrc-for:1107
14 schema:author N24a225d3682d47cba08a215e7408d353
15 schema:datePublished 1983-01
16 schema:datePublishedReg 1983-01-01
17 schema:description Inbred strains of rats differ widely in their susceptibility to interstitial nephritis induced by rabbit renal tubular basement membrane (TBM) preparations. We now report that susceptibility is determined in part by an RTI-linked gene for effector cell responsiveness producing interstitial lesions. Furthermore we also obtained evidence that the gene determining expression of the target TBM antigen is linked to the gene for albinism on the first linkage group. When non-susceptible rats lacking the TBM antigen but having the gene for cellular responsiveness were mated with non-susceptible rats which had the TBM antigen but lacked the gene for cellular responsiveness, the F1 hybrids were susceptible to the induction of interstitial nephritis. Although strains varied widely in the amount of anti-TBM antibody (αTBM-Ab) they produced, this variation does not appear to be controlled by RTI-linked genes, nor does the isotype or amount of antibody appear to be related to the susceptibility to infiltrating cellular lesions.
18 schema:genre article
19 schema:isAccessibleForFree false
20 schema:isPartOf N275824edb3874d9cbb96fd762c484446
21 N7e10f035bed043d499da26012750641b
22 sg:journal.1019755
23 schema:keywords F1 hybrids
24 RTI
25 TBM antibody
26 TBM antigen
27 albinism
28 amount
29 amount of antibody
30 anti-tubular basement membrane disease
31 antibodies
32 antigen
33 basement membrane preparation
34 cell responsiveness
35 cellular lesions
36 cellular responsiveness
37 disease
38 evidence
39 expression
40 first linkage group
41 genes
42 group
43 hybrids
44 induction
45 interstitial lesions
46 interstitial nephritis
47 isotypes
48 lesions
49 linkage groups
50 membrane disease
51 membrane preparations
52 nephritis
53 part
54 polymorphism
55 polymorphisms of genes
56 preparation
57 rats
58 responsiveness
59 strains
60 strains of rats
61 susceptibility
62 variation
63 schema:name Polymorphism of genes involved in anti-tubular basement membrane disease in rats
64 schema:pagination 55-65
65 schema:productId Na26d45465c644661b107e01fcd08612f
66 Nb6d1bf150c9f42349a43dcffdfae5e5b
67 Nbba4674dd470499194ff723178deff98
68 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010269683
69 https://doi.org/10.1007/bf00364289
70 schema:sdDatePublished 2022-10-01T06:27
71 schema:sdLicense https://scigraph.springernature.com/explorer/license/
72 schema:sdPublisher N2c3b7d96832a4f898afed3b094cdb707
73 schema:url https://doi.org/10.1007/bf00364289
74 sgo:license sg:explorer/license/
75 sgo:sdDataset articles
76 rdf:type schema:ScholarlyArticle
77 N089cd5a22d394eca960abeb346a3d4c6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
78 schema:name Albinism
79 rdf:type schema:DefinedTerm
80 N1dff920cdeb24a049439519422fb57ea schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
81 schema:name Genetic Linkage
82 rdf:type schema:DefinedTerm
83 N24a225d3682d47cba08a215e7408d353 rdf:first sg:person.01261253004.94
84 rdf:rest Ne99ae6492b124255aaff2324ea589f68
85 N275824edb3874d9cbb96fd762c484446 schema:issueNumber 1
86 rdf:type schema:PublicationIssue
87 N2c3b7d96832a4f898afed3b094cdb707 schema:name Springer Nature - SN SciGraph project
88 rdf:type schema:Organization
89 N389b29db58164aaebea4b4507eb02790 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
90 schema:name Kidney Tubules
91 rdf:type schema:DefinedTerm
92 N3b4a8dfcc53b4e0f98a57c376a14ac8c rdf:first sg:person.01150307061.98
93 rdf:rest N546fd3843fdb4d4690b73e6ac9f09d6c
94 N44754f49ceef41099ff76efa4195c833 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
95 schema:name Rats
96 rdf:type schema:DefinedTerm
97 N5457654b12a145f2ac377bc243ba7599 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
98 schema:name Autoantibodies
99 rdf:type schema:DefinedTerm
100 N546fd3843fdb4d4690b73e6ac9f09d6c rdf:first sg:person.01056265317.51
101 rdf:rest rdf:nil
102 N65a1559cd1ff4560b68849c8d8e7714c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Basement Membrane
104 rdf:type schema:DefinedTerm
105 N7e10f035bed043d499da26012750641b schema:volumeNumber 17
106 rdf:type schema:PublicationVolume
107 N8603119d1ccf4959a2a23aec365c6977 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Nephritis, Interstitial
109 rdf:type schema:DefinedTerm
110 N9786f885fc174cf9a35c44e446784cd8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name Antibody Formation
112 rdf:type schema:DefinedTerm
113 Na0a7df7e4fb6491f9c4c4b6390358038 rdf:first sg:person.0765745261.65
114 rdf:rest N3b4a8dfcc53b4e0f98a57c376a14ac8c
115 Na26d45465c644661b107e01fcd08612f schema:name doi
116 schema:value 10.1007/bf00364289
117 rdf:type schema:PropertyValue
118 Na8436107b72c405a8fc2425307baf96a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Animals
120 rdf:type schema:DefinedTerm
121 Nb6d1bf150c9f42349a43dcffdfae5e5b schema:name dimensions_id
122 schema:value pub.1010269683
123 rdf:type schema:PropertyValue
124 Nbba4674dd470499194ff723178deff98 schema:name pubmed_id
125 schema:value 6826209
126 rdf:type schema:PropertyValue
127 Ne99ae6492b124255aaff2324ea589f68 rdf:first sg:person.01320443624.18
128 rdf:rest Na0a7df7e4fb6491f9c4c4b6390358038
129 Nedad4fa52a75422da8282666818f2154 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Autoimmune Diseases
131 rdf:type schema:DefinedTerm
132 Nf19db6b79fb240d98c3364e8dcb61b23 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Lymphocyte Activation
134 rdf:type schema:DefinedTerm
135 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
136 schema:name Medical and Health Sciences
137 rdf:type schema:DefinedTerm
138 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
139 schema:name Immunology
140 rdf:type schema:DefinedTerm
141 sg:grant.2461099 http://pending.schema.org/fundedItem sg:pub.10.1007/bf00364289
142 rdf:type schema:MonetaryGrant
143 sg:grant.2682080 http://pending.schema.org/fundedItem sg:pub.10.1007/bf00364289
144 rdf:type schema:MonetaryGrant
145 sg:journal.1019755 schema:issn 0093-7711
146 1432-1211
147 schema:name Immunogenetics
148 schema:publisher Springer Nature
149 rdf:type schema:Periodical
150 sg:person.01056265317.51 schema:affiliation grid-institutes:grid.25879.31
151 schema:familyName Phillips
152 schema:givenName S. Michael
153 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01056265317.51
154 rdf:type schema:Person
155 sg:person.01150307061.98 schema:affiliation grid-institutes:grid.25879.31
156 schema:familyName Zakheim
157 schema:givenName Bruce
158 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01150307061.98
159 rdf:type schema:Person
160 sg:person.01261253004.94 schema:affiliation grid-institutes:grid.25879.31
161 schema:familyName Neilson
162 schema:givenName Eric G.
163 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01261253004.94
164 rdf:type schema:Person
165 sg:person.01320443624.18 schema:affiliation grid-institutes:grid.25879.31
166 schema:familyName Gasser
167 schema:givenName David L.
168 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01320443624.18
169 rdf:type schema:Person
170 sg:person.0765745261.65 schema:affiliation grid-institutes:grid.25879.31
171 schema:familyName McCafferty
172 schema:givenName Eileen
173 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0765745261.65
174 rdf:type schema:Person
175 grid-institutes:grid.25879.31 schema:alternateName Allergy-Immunology Section, University of Pennsylvania School of Medicine, 19104, Philadelphia, Pennsylvania
176 Department of Human Genetics, University of Pennsylvania School of Medicine, 19104, Philadelphia, Pennsylvania
177 Renal Electrolyte Section, University of Pennsylvania School of Medicine, 19104, Philadelphia, Pennsylvania
178 schema:name Allergy-Immunology Section, University of Pennsylvania School of Medicine, 19104, Philadelphia, Pennsylvania
179 Department of Human Genetics, University of Pennsylvania School of Medicine, 19104, Philadelphia, Pennsylvania
180 Renal Electrolyte Section, University of Pennsylvania School of Medicine, 19104, Philadelphia, Pennsylvania
181 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...