Polymorphism of genes involved in anti-tubular basement membrane disease in rats View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1983-01

AUTHORS

Eric G. Neilson, David L. Gasser, Eileen McCafferty, Bruce Zakheim, S. Michael Phillips

ABSTRACT

Inbred strains of rats differ widely in their susceptibility to interstitial nephritis induced by rabbit renal tubular basement membrane (TBM) preparations. We now report that susceptibility is determined in part by an RTI-linked gene for effector cell responsiveness producing interstitial lesions. Furthermore we also obtained evidence that the gene determining expression of the target TBM antigen is linked to the gene for albinism on the first linkage group. When non-susceptible rats lacking the TBM antigen but having the gene for cellular responsiveness were mated with non-susceptible rats which had the TBM antigen but lacked the gene for cellular responsiveness, the F1 hybrids were susceptible to the induction of interstitial nephritis. Although strains varied widely in the amount of anti-TBM antibody (αTBM-Ab) they produced, this variation does not appear to be controlled by RTI-linked genes, nor does the isotype or amount of antibody appear to be related to the susceptibility to infiltrating cellular lesions. More... »

PAGES

55-65

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00364289

DOI

http://dx.doi.org/10.1007/bf00364289

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1010269683

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/6826209


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