Synthesis of a defective H-2 histocompatibility antigen by mutant mouse strain BALB/c-H-2dm2 View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1982-04

AUTHORS

Peter J. Robinson

ABSTRACT

Mutant mouse strain BALB/c-H-2dm2 (dm2), which fails to express the H-2Ld histocompatibility antigen associated with the wild type, BALB/c, synthesizes instead a smaller molecule that is structurally related to H-2Ld but does not carry detectable alloantigenic determinants. This new protein, p40, is a membrane glycoprotein found in dm2 cells but not in BALB/c. p40 was detected by electrophoresis of dm2 glycoprotein preparations and by immunoprecipitation with heterologous H-2-specific antibodies. The p40 molecule is found associated with intracellular membranes but was not detected at the cell surface. Peptide mapping studies suggest that dm2 carries an alteration in the H-2Ld structural gene, which prevents proper maturation of the protein product. More... »

PAGES

333-340

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00364257

DOI

http://dx.doi.org/10.1007/bf00364257

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1017972666

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/7076287


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