1984-09
AUTHORSRobert E. Click, David Schneider, Lisa A. Sitzmann, Miguel M. Azar
ABSTRACTThe Mls locus was originally defined to have four alleles; three controlled products that were detectable in primary mixed leukocyte reactions (MLR), whereas one, b, was described as being null. Recently, other investigators postulated that the Mls locus is nonpolymorphic, being composed of the b null allele and of a singly expressed allele previously thought to be the a and d alleles. We previously reported that products controlled by Mlsaand Mlsdwere antigenically distinct and therefore are not controlled by the same allele, and the product of Mlsbon cells of three different strains was easily detectable by Mlsaand Mlsdresponding cells. Thus the b allele is not null. In the present report evidence is presented which indicates that both Mlsband Mlscencoded products were undetectable by MLR when in the presence of Mlsaor Mlsd. This was demonstrated by (a) the inability of Mlsa/Mlscand Mlsa/MlsbF1 cells to stimulate Mlsaresponding cells and Mlsd/Mlscand Mlsd/Mlsbcells to stimulate Mlsdcells; (b) the positive response of Mlsa/Mlsband Mlsd/MlsbF1-hybrid cells to Mlsb-encoded products; and (c) the reactivity of Mlsa/Mlscand Mlsd/MlscF1 hybrid cells to Mlsc-encoded determinants. More... »
PAGES301-310
http://scigraph.springernature.com/pub.10.1007/bf00364211
DOIhttp://dx.doi.org/10.1007/bf00364211
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1030530578
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/6205991
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Immunology",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Alleles",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Animals",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Crosses, Genetic",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Epitopes",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Genes, MHC Class II",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "H-2 Antigens",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Lymphocytes",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Major Histocompatibility Complex",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Mice",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Mice, Inbred Strains",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Species Specificity",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Research Service, VA Medical Center and Departments of Microbiology and Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota",
"id": "http://www.grid.ac/institutes/grid.17635.36",
"name": [
"Research Service, VA Medical Center and Departments of Microbiology and Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota"
],
"type": "Organization"
},
"familyName": "Click",
"givenName": "Robert E.",
"id": "sg:person.07452362074.22",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07452362074.22"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Research Service, VA Medical Center and Departments of Microbiology and Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota",
"id": "http://www.grid.ac/institutes/grid.17635.36",
"name": [
"Research Service, VA Medical Center and Departments of Microbiology and Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota"
],
"type": "Organization"
},
"familyName": "Schneider",
"givenName": "David",
"id": "sg:person.01112270765.23",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01112270765.23"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Research Service, VA Medical Center and Departments of Microbiology and Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota",
"id": "http://www.grid.ac/institutes/grid.17635.36",
"name": [
"Research Service, VA Medical Center and Departments of Microbiology and Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota"
],
"type": "Organization"
},
"familyName": "Sitzmann",
"givenName": "Lisa A.",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Research Service, VA Medical Center and Departments of Microbiology and Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota",
"id": "http://www.grid.ac/institutes/grid.17635.36",
"name": [
"Research Service, VA Medical Center and Departments of Microbiology and Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota"
],
"type": "Organization"
},
"familyName": "Azar",
"givenName": "Miguel M.",
"id": "sg:person.074540472.35",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.074540472.35"
],
"type": "Person"
}
],
"citation": [
{
"id": "sg:pub.10.1038/306080a0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1042014029",
"https://doi.org/10.1038/306080a0"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/bf01572583",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1038611513",
"https://doi.org/10.1007/bf01572583"
],
"type": "CreativeWork"
}
],
"datePublished": "1984-09",
"datePublishedReg": "1984-09-01",
"description": "The Mls locus was originally defined to have four alleles; three controlled products that were detectable in primary mixed leukocyte reactions (MLR), whereas one, b, was described as being null. Recently, other investigators postulated that the Mls locus is nonpolymorphic, being composed of the b null allele and of a singly expressed allele previously thought to be the a and d alleles. We previously reported that products controlled by Mlsaand Mlsdwere antigenically distinct and therefore are not controlled by the same allele, and the product of Mlsbon cells of three different strains was easily detectable by Mlsaand Mlsdresponding cells. Thus the b allele is not null. In the present report evidence is presented which indicates that both Mlsband Mlscencoded products were undetectable by MLR when in the presence of Mlsaor Mlsd. This was demonstrated by (a) the inability of Mlsa/Mlscand Mlsa/MlsbF1 cells to stimulate Mlsaresponding cells and Mlsd/Mlscand Mlsd/Mlsbcells to stimulate Mlsdcells; (b) the positive response of Mlsa/Mlsband Mlsd/MlsbF1-hybrid cells to Mlsb-encoded products; and (c) the reactivity of Mlsa/Mlscand Mlsd/MlscF1 hybrid cells to Mlsc-encoded determinants.",
"genre": "article",
"id": "sg:pub.10.1007/bf00364211",
"inLanguage": "en",
"isAccessibleForFree": false,
"isPartOf": [
{
"id": "sg:journal.1019755",
"issn": [
"0093-7711",
"1432-1211"
],
"name": "Immunogenetics",
"publisher": "Springer Nature",
"type": "Periodical"
},
{
"issueNumber": "3",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "20"
}
],
"keywords": [
"mixed leukocyte reaction",
"primary mixed leukocyte reaction",
"Mls locus",
"leukocyte reaction",
"immune response",
"report evidence",
"positive response",
"cells",
"different strains",
"alleles",
"same allele",
"response",
"MLSB",
"hybrid cells",
"Mlsc",
"investigators",
"null alleles",
"evidence",
"determinants",
"inability",
"reactivity",
"presence",
"strains",
"loci",
"MLSD",
"products",
"reaction"
],
"name": "Immune responses in vitro",
"pagination": "301-310",
"productId": [
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1030530578"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1007/bf00364211"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"6205991"
]
}
],
"sameAs": [
"https://doi.org/10.1007/bf00364211",
"https://app.dimensions.ai/details/publication/pub.1030530578"
],
"sdDataset": "articles",
"sdDatePublished": "2022-05-20T07:17",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-springernature-scigraph/baseset/20220519/entities/gbq_results/article/article_178.jsonl",
"type": "ScholarlyArticle",
"url": "https://doi.org/10.1007/bf00364211"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/bf00364211'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/bf00364211'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/bf00364211'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/bf00364211'
This table displays all metadata directly associated to this object as RDF triples.
161 TRIPLES
22 PREDICATES
67 URIs
57 LITERALS
18 BLANK NODES