Ontology type: schema:ScholarlyArticle
1984-09
AUTHORSGeorge A. Carlson, Benjamin A. Taylor, Susan T. Marshall, Arnold H. Greenberg
ABSTRACTThe genetic control of natural resistance in vivo to four natural killer (NK) cell-resistant H-2 homozygous lymphoid tumor cell lines was investigated by following the survival and organ distribution of cells prelabeled with radioactive iododeoxyuridine. Backcross mice derived from DBA/2J and CBA/J parents were injected with H-2dtumor cells and tumor cell elimination was lowest in H-2dhomozygotes. Natural killer cell activity was also reduced in mice with the H-2dhaplotype, but no direct correlation between NK cell levels against YAC-1 or SL2-5 lymphoma cells and natural resistance in vivo was demonstrable. Analysis of 23 BXD recombinant inbred strains indicated that natural resistance to H-2dtumors was restricted to H-2bstrains. There was no direct association of NK cell activity with H-2 type in the BXD strains and NK cell levels did not correlate with tumor survival in vivo. By comparing natural resistance to H-2dand H-2btumors in DBA/2, C57BL/6, B6D2F1, and B10.D2 mice we found that H-2 nonidentity between the tumor and the host, rather than the host H-2 haplotype, determined whether natural resistance occurred. Again, NK cell activity against YAC-1 cells was not predictive of tumor survival in these strains. These results provide genetic evidence that NK cells alone cannot account for natural resistance to H-2 nonidentical cells of hemopoietic origin. More... »
PAGES287-300
http://scigraph.springernature.com/pub.10.1007/bf00364210
DOIhttp://dx.doi.org/10.1007/bf00364210
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PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/6469290
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