Proximal tubular reabsorption of some organic acids in the rat kidney in vivo View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1965-06

AUTHORS

Harald Sonnenberg, Hellmut Oelert, Karl Baumann

ABSTRACT

Using a microperfusion technique proximal tubular reabsorption of sulfamerazine, phenobarbital, p-aminohippuric acid, uric acid, sulfaurea and N4-acetylsulfamerazine was studied as a function of intratubular pH in the rat kidney in vivo. Transtubular permeabilities were related to in vitro lipoid solubility measurements and degrees of non-dissociation of the acids. It was found thatsulfamerazine and phenobarbital exhibit nonionic backdiffusion, the magnitude of which is dependent on lipoid solubility,p-aminohippuric acid, uric acid and sulfaurea do not show this backdiffusion, a finding explained by lack of lipoid solubility,N4-acetylsulfamerazine, despite relatively high lipoid solubility, is not reabsorbed in the proximal tubule. sulfamerazine and phenobarbital exhibit nonionic backdiffusion, the magnitude of which is dependent on lipoid solubility, p-aminohippuric acid, uric acid and sulfaurea do not show this backdiffusion, a finding explained by lack of lipoid solubility, N4-acetylsulfamerazine, despite relatively high lipoid solubility, is not reabsorbed in the proximal tubule. More... »

PAGES

171-180

References to SciGraph publications

  • 1965-03. Der tubuläre Transport von p-Aminohippursäure in PFLÜGERS ARCHIV - EUROPEAN JOURNAL OF PHYSIOLOGY
  • 1902-10. Beiträge zur allgemeinen Muskel- und Nervenphysiologie in PFLÜGERS ARCHIV - EUROPEAN JOURNAL OF PHYSIOLOGY
  • 1958-08. Wasserrückresorption und Ionentransport durch die Sammelrohrzellen der Säugetierniere in PFLÜGERS ARCHIV - EUROPEAN JOURNAL OF PHYSIOLOGY
  • 1962-01. Pressure and flow in proximal tubules of rat kidneys in CELLULAR AND MOLECULAR LIFE SCIENCES
  • 1964-11. Methode zur Durchströmung einzelner Nephronabschnitte in PFLÜGERS ARCHIV - EUROPEAN JOURNAL OF PHYSIOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/bf00363859

    DOI

    http://dx.doi.org/10.1007/bf00363859

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1032560748

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/5221295


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