Ontology type: schema:ScholarlyArticle
1968-06
AUTHORSO. Rougier, G. Vassort, R. Stämpfli
ABSTRACTVoltage clamp experiments with the double sucrose gap technique performed on frog heart atrial trabecles show:an initial sodium current as function of potential and time, blocked by TTX. Its activation is accelerated with increased depolarization. Its inactivation has a rapid phase with a time constant of the order of a millisecond, followed by a very slow phasea delayed rectification, superimposed on anomalous rectification. Steady state current voltage curves have sigmoid shape. The delayed currents are only very little reduced by TEAnegative currents decreasing with time during hyperpolarizing voltage steps. They are strongly reduced by TEA which suggests a high potassium conductance at the beginning of the steps.These results confirm the findings of McAllister and Noble (1966, 1967) concerning the existence of a delayed rectification in cardiac muscle fibres. With respect to the sodium system they are to a certain extent in agreement with the ones of Giebisch and Weidmann (1967) and with the hypothesis of Brady and Woodbury (1960). They can qualitatively explain the time course of the action potential. More... »
PAGES91-108
http://scigraph.springernature.com/pub.10.1007/bf00362729
DOIhttp://dx.doi.org/10.1007/bf00362729
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