CD15 (LeuM1) immunoreactivity: Prognostic factor for sporadic and hereditary medullary thyroid cancer? View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1994-07

AUTHORS

Friedrich Längle, Thomas Soliman, Nikolaus Neuhold, Gerold Widhalm, Bruno Niederle, Sebastian Roka, K. Kaserer, Wolfgang Blauensteiner, Karl Dam, Martin Clodi, Juan Flores, Almute Loidl, Bernhard Schwarzlmüller, Eva Huber, Gerald Jahl, Klaus Wamprechtshammer, Rudolf Roka, Study Group on Multiple Endocrine Neoplasia of Austria

ABSTRACT

Patients treated for sporadic and hereditary medullary thyroid carcinoma (MTC) have varying rates of persistent disease, recurrence, and survival. The aim of this study was to correlate the immunoreactivity of the monoclonal antibody CD15 (LeuM1) to initial clinical findings and the outcome of treatment. The primary tumors of 75 patients with sporadic MTC, 7 with hereditary disease, and 3 members of MEN 2A families were studied. Of these subjects 74 (87%) showed no or little immunoreactivity (<15% positive cells; score 0) in most tumors. The remaining 13% had surgery for tumors with more than 15% cells with positive staining (score I). There was no correlation between LeuM1 immunoreactivity and sex, age, and type of MTC. There was, however, a significant correlation with the pTNM classification and UICC staging. The prognosis for patients with score 0 was significantly better than score 1 patients. CD15 immunoreactivity appears to be a predictive factor in sporadic and hereditary MTC. Lymph node dissection seems to be more successful in patients with score 0 tumors than in those with score 1 tumors. The question of reoperation in patients with recurrence of disease (especially with biochemical recurrence or persistence) should be discussed on the basis of CD15 immunoreactivity. More... »

PAGES

583-587

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00353771

DOI

http://dx.doi.org/10.1007/bf00353771

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1030369814

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/7725748


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26 schema:description Patients treated for sporadic and hereditary medullary thyroid carcinoma (MTC) have varying rates of persistent disease, recurrence, and survival. The aim of this study was to correlate the immunoreactivity of the monoclonal antibody CD15 (LeuM1) to initial clinical findings and the outcome of treatment. The primary tumors of 75 patients with sporadic MTC, 7 with hereditary disease, and 3 members of MEN 2A families were studied. Of these subjects 74 (87%) showed no or little immunoreactivity (<15% positive cells; score 0) in most tumors. The remaining 13% had surgery for tumors with more than 15% cells with positive staining (score I). There was no correlation between LeuM1 immunoreactivity and sex, age, and type of MTC. There was, however, a significant correlation with the pTNM classification and UICC staging. The prognosis for patients with score 0 was significantly better than score 1 patients. CD15 immunoreactivity appears to be a predictive factor in sporadic and hereditary MTC. Lymph node dissection seems to be more successful in patients with score 0 tumors than in those with score 1 tumors. The question of reoperation in patients with recurrence of disease (especially with biochemical recurrence or persistence) should be discussed on the basis of CD15 immunoreactivity.
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34 CD15 immunoreactivity
35 MEN 2A families
36 UICC staging
37 age
38 aim
39 basis
40 cancer
41 carcinoma
42 cells
43 classification
44 clinical findings
45 correlation
46 disease
47 dissection
48 factors
49 family
50 findings
51 hereditary disease
52 hereditary medullary thyroid cancer
53 hereditary medullary thyroid carcinoma
54 immunoreactivity
55 initial clinical findings
56 little immunoreactivity
57 lymph
58 medullary thyroid cancer
59 medullary thyroid carcinoma
60 members
61 most tumors
62 outcome of treatment
63 outcomes
64 pTNM classification
65 patients
66 persistent disease
67 positive staining
68 predictive factors
69 primary tumor
70 prognosis
71 prognostic factors
72 questions
73 rate
74 recurrence
75 recurrence of disease
76 reoperation
77 score 0
78 sex
79 significant correlation
80 sporadic medullary thyroid carcinoma
81 staging
82 staining
83 study
84 surgery
85 survival
86 thyroid cancer
87 thyroid carcinoma
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89 tumors
90 types
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