Mitotic hyperploidy for chromosomes VIII and III in Saccharomyces cerevisiae View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1992-04

AUTHORS

Lorraine M. Spector, Seymour Fogel

ABSTRACT

The arg4-8 and cup1s markers comprise a copy-number-dependent signal device in the yeast Saccharomyces cerevisiae. These alleles permit reliable discrimination between euploid and disomic haploids as well as between euploid and trisomic diploids. To investigate and compare inherent inter-chromosomal differences as regards propensity for hyperploidy, we transplaced arg4-8 and cup1s by deleting them from chromosome VIII and then re-introducing them at the leu2 locus on chromosome III. The rate of chromosome gain was significantly greater for the chromosome III construct compared to the native chromosome VIII, in both diploid and haploid strains. In addition, more coincident aneuploidy for other chromosomes was found among chromosome VIII hyperploids compared to chromosome III hyperploids. More... »

PAGES

309-318

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00351688

DOI

http://dx.doi.org/10.1007/bf00351688

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1038606721

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/1525859


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