Meiotic mapping of murine chromosome 17: The string of loci around l(17)-2Pas View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1991-03

AUTHORS

Thomas R. King, William F. Dove, Jean-Louis Guénet, Bernhard G. Herrmann, Alexandra Shedlovsky

ABSTRACT

We describe a genetic analysis of l(17)-2Pas, an embryonic lethal mutation on murine chromosome 17. Males transmitted the l(17)-2 allele to only 38% of their offspring, whereas females transmitted this allele at 50%. Two-point crosses revealed tight linkage between l(17)-2 and brachyury (T), and deletion mapping placed l(17)-2 outside of the hairpin-tail deletion (Thp). To map this mutation more precisely, we intercrossed hybrid mice that carry distinct alleles at many classical and DNA loci on chromosome 17 and obtained 172 animals recombinant in the T to H-2 region. Strong positive interference was observed over the 14 cM interval from T to H-2K. Thus, a single recombinant can be informative; one such recombinant places l(17)-2 distal of the molecular marker D17Leh66D. Robust genetic maps can be constructed with multilocus crosses that share anchor loci. DNA markers can be interpolated onto these maps retrospectively. More... »

PAGES

37-46

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00350844

DOI

http://dx.doi.org/10.1007/bf00350844

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1034736314

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/1794044


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Turtle is a human-readable linked data format.

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RDF/XML is a standard XML format for linked data.

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