Bone marrow purging with mafosfamide — A critical survey View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1989-11

AUTHORS

H. Sindermann, M. Peukert, P. Hilgard

ABSTRACT

Autologous bone marrow transplantation (ABMT) is increasingly used to consolidate remissions, primarily in hematological disease. Various purging strategies have been developed to minimize the risk of reimplantation of tumor cells with the bone marrow autotransplant. Pharmacological purging with the oxazaphosphorine derivative mafosfamide has been studied extensively, and recent clinical data suggest that purging with mafosfamide may translate into superior remission duration if compared to nonpurged ABMT in acute leukemia. Chemical and experimental data relevant to mafosfamide-purging and clinical results are reviewed, with special emphasis on safety aspects. More... »

PAGES

432-441

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00349064

DOI

http://dx.doi.org/10.1007/bf00349064

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1021978212

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/2684298


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