Ontology type: schema:ScholarlyArticle
1991-05
AUTHORSM. Sasaki, T. Arai, Y. Oki, K. Komeda
ABSTRACTAn ultrastructural study was performed on the pancreatic islet cells of normal herbivorous voles and of voles in which diet-induced diabetes had been induced by feeding a low-fibre, high-concentrate diet. Examination of the pancreatic islet cells revealed degranulation and a well-developed Golgi apparatus and rough endoplasmic reticulum in the B cells of the slightly diabetic voles showing moderate hyperglycaemia and hyperinsulinaemia, and markedly degenerative B cells with almost complete absence of secretory granules in the severely diabetic voles showing marked hyperglycaemia and hypoinsulinaemia.These results indicate that the pancreatic B cells had become hyperfunctional so that insulin secretion was increased in the slightly diabetic voles; thereafter the B cells degenerated rapidly and the voles fell into insulin deficiency. More... »
PAGES205-210
http://scigraph.springernature.com/pub.10.1007/bf00343225
DOIhttp://dx.doi.org/10.1007/bf00343225
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PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/1882514
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