Anti-LFA1 monoclonal antibody (25.3) for treatment of steroid-resistant grade III–IV acute graft-versus-host disease View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1991-04

AUTHORS

A. M. Stoppa, D. Maraninchi, D. Blaise, P. Viens, M. Hirn, D. Olive, J. Reiffers, N. Milpied, M. H. Gaspard, C. Mawas

ABSTRACT

The in vivo efficacy of 25.3 monoclonal antibody (mAb) directed against human LFA1 molecule was assessed in ten patients with steroid-resistant grade III–IV acute graft-versus-host disease (AGVHD). These patients received non-T-cell-depleted allogeneic bone marrow transplantation for aplastic anemia in two cases and hematologic malignancies in eight cases. Five grafts were fully matched, three were one antigen-mismatched, and two were two antigen-mismatched. Despite GVHD prophylaxis with cyclosporin A and short-term methotrexate, AGVHD occurred after a median of 24 days and clearly progressed under prednisone (median 2 mg/kg), given for a median of 12 days. 25.3 mAb was given at a dosage of 0.1 mg/kg in a 4-h perfusion for five daily doses without any clinical or biological side effects. Thirty percent of the patients experienced a reduction in the overall grading with two complete responses. Partial response in at least one involved organ (mostly skin) occurred in 80% of the patients. However, seven out of the eight responding patients experienced a new episode of AGVHD. This observation, which confirms that inhibiting a functional molecule is as efficient as a cytolytic therapy, offers an alternative strategy to antithymocyte globulin (ATG) and cytotoxic mAb in controlling steroid-resistant GVHD. More... »

PAGES

3-7

References to SciGraph publications

  • 1983-03. High dose bolus methylprednisolone for the treatment of acute graft versus host disease in BLUT ZEITSCHRIFT FÜR DIE GESAMTE BLUTFORSCHUNG
  • 1985. Human Lymphocyte Functional Antigens in HUMAN T CELL CLONES
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/bf00335508

    DOI

    http://dx.doi.org/10.1007/bf00335508

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1035276645

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/2059297


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