Cortical tubers demonstrate reduced immunoreactivity for synapsin I View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1993-07

AUTHORS

C. F. Lippa, D. Pearson, T. W. Smith

ABSTRACT

To evaluate the effects of tuberous sclerosis (TS) on cortical synaptic organization, we analyzed synaptic densities within cortical tubers from the brains of two TS patients using a polyclonal antibody directed against synapsin I, a synaptic terminal-specific protein. The synaptic densities of the tubers and adjacent histologically normal cortex were obtained by determining optical densities using an IBAS (Zeiss) image analysis system. The tubers showed abnormally low levels of synapsin I compared with the normal cortex. The data suggest that cortical tubers do not contain a normal complement of synapses. This may reflect focal underdevelopment of normal cortical-cortical connections. Altered afferent corticla projections may also contribute to synaptic loss in cortical tubers. More... »

PAGES

449-451

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00334458

DOI

http://dx.doi.org/10.1007/bf00334458

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1053184202

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/8480517


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