The induction of a specific pigment cell type by total genomic DNA injected into the neural crest region of fish ... View Full Text


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Article Info

DATE

1982-05

AUTHORS

Jürgen Vielkind, Hertraut Haas-Andela, Ursula Vielkind, Fritz Anders

ABSTRACT

We report genetic transformation in an intact higher organism, i.e., in xiphophorine fish. The gene to be transferred (Tu) is responsible for the formation of T-melanophores in the platyfish and is involved in the formation of melanomas in platyfish-swordtail hybrids. After injection of Tu-donor DNA into the neural crest region of embryos from Tu-free fish, some of the recipients developed T-melanophores. In a few cases, one or two single T-melanophores were formed during late embryo-genesis. In most cases, many T-melanophores developed in young fish and were arranged in several colonies or in a pattern. DNase-degraded Tu-donor DNA, Tu-free fish DNA, as well as DNA from E. coli and adenovirus-2, did not induce T-melanophores. When using DNA from different strains of Tu-donor fish which differed in a regulating gene linked to Tu, the percentages of fish showing T-melanophores paralleled the degree of phenotypic expression of the Tu gene in the DNA donor. The results suggest that the Tu gene has been successfully transferred together with the linked regulating gene. More... »

PAGES

379-389

References to SciGraph publications

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/bf00334128

    DOI

    http://dx.doi.org/10.1007/bf00334128

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1021451910

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/6954345


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