Nonexchange alignment: A meiotic process revealed by a synthetic meiotic mutant of Drosophila melanogaster View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1971-06

AUTHORS

Leonard G. Robbins

ABSTRACT

Summarymei-S51 is a meiotic mutant of Drosophila melanogaster having the following properties:mei-S51 consists of two recessive genes, located near the centromere regions of the second and third chromosomes, which are both required for the expression of the mutant phenotype. Salivary analysis reveals normal structures for both the second and third chromosomes.mei-S51 has no effect in males but in females it causes a uniform decrease in X chromosome exchange, second chromosome exchange between c and bw, and increased nondisjunction of all chromosomes. Both of these effects appear to result from a defect prior to both exchange and disjunction, rather than one being the cause of the other.Nondisjunction in mei-S51 females having a normal sex chromosome complement is the result of nonhomologous pairing as is the greatly increased nondisjunction found for XXY; mei-S51 females. This nondisjunction is not competitive with exchange; that is, exchange occurs as frequently between the X chromosomes of XXY females as those of XX females in spite of a greatly increased frequency of X chromosome nondisjunction in the former.There is a pronounced increase in the frequency of nondisjunction in both XX and XXY; mei-S51 females if the X chromosomes are heterozygous for the inversion, In(1)dl49, although heterozygosity for In(1)dl49 causes-only a slight increase in nondisjunction in mei-S51+ (normal) XX females.It appears unlikely that, in all instances of nonhomologous pairing, both chromosomes of each bivalent pair nonhomologously. Rather, in many instances one chromosome pairs with a nonhomolog and the other two elements are distributed at random and without loss to the poles.In XX; mei-S51 females, nonhomologous pairing of the fourth chromosomes occurs exclusively with the X chromosomes, implying that the specificity of nonhomologous pairing (perhaps the size recognition mechanism demonstrated by Grell) is not affected by mei-S51.An hypothesis explaining these observations and a discussion of its implications with regard to the normal course of meiosis and the mechanism of nonhomologous pairing are presented. More... »

PAGES

144-166

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00332645

DOI

http://dx.doi.org/10.1007/bf00332645

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1081163077

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/5550310


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