Size variation in group A streptococcal M protein is generated by homologous recombination between intragenic repeats View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1987-05

AUTHORS

Susan K. Hollingshead, Vincent A. Fischetti, June R. Scott

ABSTRACT

M protein, a major surface protein and virulence factor for the group A streptococcus, exhibits extraordinary size variation in strains of the same serotype (Fischetti et al. 1985). RNA sequence analysis of spontaneous M protein size variants shows that deletion mutations arise in a single strain by homologous recombination events between intragenic tandem repeats. Similar deletion and duplication events also occur in serial streptococcal isolates from a single patient and among related strains in a recent outbreak. We discuss how homologous recombination events can lead to the generation of antigenic variation. More... »

PAGES

196-203

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00331578

DOI

http://dx.doi.org/10.1007/bf00331578

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1027520195

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/3039291


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