Identification and nucleotide sequence of the class E tet regulatory elements and operator and inducer binding of the encoded purified ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1988-12

AUTHORS

K. Tovar, A. Ernst, W. Hillen

ABSTRACT

The regulatory region and repressor (tetRE) gene from the class E tetracycline resistance determinant previously isolated from Enterobacteriaceae have been identified and completely sequenced. The regulatory region is located between the resistance gene and the tetR gene which have opposite polarity. The tetR gene encodes a protein consisting of 211 amino acids with a calculated molecular weight of 23.6 kDa. Cloning of the tetR gene under transcriptional control of the λ PL promoter leads to overexpression of a polypeptide with an apparent molecular weight of 26 kDa. The purified protein binds sequence specifically to DNA fragments containing putative tet operators. This property is lost in the presence of tetracycline. The relationship of the tetRE sequence to four known tetracycline resistance determinants is discussed. More... »

PAGES

76-80

Journal

TITLE

Molecular Genetics and Genomics

ISSUE

1

VOLUME

215

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/bf00331306

    DOI

    http://dx.doi.org/10.1007/bf00331306

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1019299795

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/3241623


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