Studies of multipolar mitoses in euploid tissue cultures View Full Text


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Article Info

DATE

1973-03

AUTHORS

F. Pera, B. Rainer

ABSTRACT

Cultures of kidney epithelium and fibroblasts of 39 specimens of Microtus agrestis were investigated. In all 77 cultures multipolar mitoses were found. They were studied in living state and after pulse labelling with 3H-thymidine. The ploidy of the multipolar mitoses and of their daughter nuclei was determined by measuring the relative Feulgen-DNA content and by counting the predominantly constitutive heterochromatic sex chromosomes. Constitutive heterochromatin was demonstrated by late replication, retarded separation of the chromatids in anaphase, heteropycnosis and by the Giemsa technique of Arrighi and Hsu (1971). The latter stained also the spindle apparatus of mitoses.—In living cells, transformation of multipolar mitoses into bipolar mitoses was observed. The chromosomes of multipolar mitoses are separated into complete genomes; the daughter nuclei can be haploid, diploid, triploid or tetraploid. The chromosomes of haploid and triploid metaphases were studied with the Giemsa banding technique. The banding pattern shows an exact monosomy and trisomy, respectively, for each chromosome. Haploid nuclei are likely to be viable only in multinucleate cells, whereas triploid cells behave like diploid cells during the S period and the mitosis. More... »

PAGES

71-86

References to SciGraph publications

  • 1971-06. Staining of Satellite DNA in Metaphase Chromosomes in NATURE
  • 1892-04. Über Kernteilung bei Riesenzellen nach Beobachtungen an der Embryonalen Säugetierleber in BRAIN STRUCTURE AND FUNCTION
  • 1969-09. Struktur und Position der heterochromatischen Chromosomen in Interphasekernen von Microtus agrestis in CELL AND TISSUE RESEARCH
  • 1959-08. Induction of multipolar spindles by single X-irradiated sperm in CELLULAR AND MOLECULAR LIFE SCIENCES
  • 1974-06. Studies of multipolar mitoses in euploid tissue cultures in CHROMOSOMA
  • 1972-09. Pattern of repetitive DNA of the chromosomes of Microtus agrestis in CHROMOSOMA
  • 1967-09. DNS-Replikation und Morphologie der X-Chromosomen während der Syntheseperiode bei Microtus agrestis in CHROMOSOMA
  • 1911-07. Die Reduktionsorte und Sauerstofforte des tierischen Gewebes in ARCHIV FÜR MIKROSKOPISCHE ANATOMIE
  • 1960-01. Rates of meiosis, spindle irregularities and microsporocyte division in Bromus trinii × B. carinatus in CHROMOSOMA
  • 1970-02. Polykaryocytosis and mitosis in a human cell line after treatment with measles virus in HEREDITAS
  • 1968-06. Formation and division of binucleated cells in kidney cell cultures of microtus agrestis in HUMANGENETIK
  • 1955-01. Die Identifizierung der Chromosomen im Karyotyp der Rattenleber in CHROMOSOMA
  • 1966-05. Cytologic and genetic evidence of somatic segregation in mammals, birds, and fishes in IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY
  • 1969-09. Die Verteilung der Chromosomen auf die Tochterzellkerne multipolarer Mitosen in euploiden Gewebekulturen von Microtus agrestis in CHROMOSOMA
  • 1967-03. Sporadic triploid cells in human blood and fibroblast cultures in HUMANGENETIK
  • 1971-12. Analysis of the human karyotype using a reassociation technique in CHROMOSOMA
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/bf00326331

    DOI

    http://dx.doi.org/10.1007/bf00326331

    DIMENSIONS

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    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/4123256


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