Screening of gene deletions by polymerase chain reaction in Japanese patients with Duchenne muscular dystrophy View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1991-02

AUTHORS

T. Nakajima, M. Matsuo, Y. Kitoh, T. Takumi, H. Nishio, T. Masumura, J. Koga, H. Nakamura

ABSTRACT

Gene deletions were screened in 49 Japanese Duchenne muscular dystrophy patients from 43 families, using the polymerase chain reaction. Enzymatic amplification was carried out on six regions prone to deletion. Fifteen of 43 families (33%) had gene deletions in at least one of the six regions. This frequency was almost the same as that previously reported in Caucasians. The mid-part of the dystrophin gene was the location most frequently deleted. The frequency of deletion of the region encompassing exon 45 was higher in Japanese families (18.4%) than in Caucasians. More... »

PAGES

6-8

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00319701

DOI

http://dx.doi.org/10.1007/bf00319701

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1013646659

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/2030378


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