Nonlinear kinetics of threo-methylphenidate enantiomers in a patient with narcolepsy and in healthy volunteers View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1993-01

AUTHORS

T. Aoyama, H. Kotaki, T. Sasaki, Y. Sawada, Y. Honda, T. Iga

ABSTRACT

We have studied the pharmacokinetics of methylphenidate enantiomers after the oral administration of different doses of racemic methylphenidate to one patient with narcolepsy and to four healthy volunteers.The plasma concentrations of (+)-methylphenidate were much higher than those of (−)-methylphenidate after each dose in all subjects. In the patient the oral clearance (CL/f) of (+)-methylphenidate fell 3-fold and the area under the concentration-time curve (AUC) rose 7-fold when the dose was increased from 20 to 40 mg (from 0.27 to 0.53 mg·kg−1), in spite of the relatively constant terminal half-life of 2.6–2.7 h.Similar dose-dependency was also observed in the healthy volunteers in the dose range of 10–60 mg (0.12–0.77 mg·kg−1). The mean value of CL/f for the 40 mg dose was significantly lower than that for the 20 mg dose. The mean AUC of the (+)-isomer corrected to a dose of 10 mg increased significantly between the 20 mg and 40 mg doses.In the urine (+)- and (−)-ritalinic acid were excreted for 48 h after each dose as 32–37% and 34–40% of the dose respectively. The mean total recoveries (sum of enantiomers of methylphenidate and its metabolite, ritalinic acid) in the urine were relatively constant (63–78% of the doses), suggesting that the changes in AUC with dose may not be due to a change in the intestinal absorption of racemic methylphenidate.We conclude that the nonlinear kinetics of (+)-methylphenidate may be due to saturation of its presystemic elimination. More... »

PAGES

79-84

Journal

Related Patents

  • Methods For Treatment Of Cognitive And Menopausal Disorders With D-Threo Methylphenidate
  • Methods Of Treatment Of Attention Deficit Hyperactivity Disorder
  • Methods For Treatment Of Attention Deficit Hyperactivity Disorder
  • Methods For Treatment Of Attention Deficit Hyperactivity Disorder
  • Method Of Treatment Of Attention Deficit Hyperactivity Disorder
  • Delivery Of Multiple Doses Of Medications
  • Composition Comprising Methylphenidate And Another Drug
  • Pharmaceutical Dosage Form For Pulsatile Delivery Of D-Threo-Methylphenidate And A Second Cns Stimulant
  • Compositions For Treatment Of Attention Deficit Hyperactivity Disorder
  • Compositions For Treatment Of Attention Deficit Hyperactivity Disorder
  • Compositions For Treatment Of Attention Deficit Hyperactivity Disorder
  • Compositions For Treatment Of Attention Deficit Hyperactivity Disorder
  • Methods And Compositions For Treatment Of Attention Deficit Disorder
  • Methods For Treatment Of Attention Deficit Hyperactivity Disorder
  • Compositions For Treatment Of Attention Deficit Hyperactivity Disorder
  • Treatment Of Convulsive States
  • Compositions For Treatment Of Attention Deficit Hyperactivity Disorder
  • Compositions For Treatment Of Attention Deficit Hyperactivity Disorder
  • Compositions For Treatment Of Attention Deficit Hyperactivity Disorder
  • Process And Intermediates For Resolving Piperidyl Acetamide Steroisomers
  • The Treatment Of Convulsive States
  • Processes And Intermediates For Resolving Piperidyl Acetamide Stereoisomers
  • The Treatment Of Convulsive States
  • Methods Of Treatment Of Attention Deficit Hyperactivity Disorder
  • Compositions For Treatment Of Attention Deficit Hyperactivity Disorder
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/bf00315285

    DOI

    http://dx.doi.org/10.1007/bf00315285

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1035164371

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/8436161


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Clinical Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Administration, Oral", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adult", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Methylphenidate", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Narcolepsy", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Stereoisomerism", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Department of Pharmacy, The University of Tokyo Hospital, Faculty of Medicine, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.412708.8", 
              "name": [
                "Department of Pharmacy, The University of Tokyo Hospital, Faculty of Medicine, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Aoyama", 
            "givenName": "T.", 
            "id": "sg:person.011206573461.15", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011206573461.15"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pharmacy, The University of Tokyo Hospital, Faculty of Medicine, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.412708.8", 
              "name": [
                "Department of Pharmacy, The University of Tokyo Hospital, Faculty of Medicine, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kotaki", 
            "givenName": "H.", 
            "id": "sg:person.01127405054.09", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01127405054.09"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Neuropsychiatric Research Institute, Seiwa Hospital, Bentencho, Shinjuku-ku, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.419280.6", 
              "name": [
                "Neuropsychiatric Research Institute, Seiwa Hospital, Bentencho, Shinjuku-ku, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sasaki", 
            "givenName": "T.", 
            "id": "sg:person.016005236422.74", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016005236422.74"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pharmacy, The University of Tokyo Hospital, Faculty of Medicine, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.412708.8", 
              "name": [
                "Department of Pharmacy, The University of Tokyo Hospital, Faculty of Medicine, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sawada", 
            "givenName": "Y.", 
            "id": "sg:person.01270034754.54", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01270034754.54"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Neuropsychiatric Research Institute, Seiwa Hospital, Bentencho, Shinjuku-ku, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.419280.6", 
              "name": [
                "Neuropsychiatric Research Institute, Seiwa Hospital, Bentencho, Shinjuku-ku, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Honda", 
            "givenName": "Y.", 
            "id": "sg:person.01155455224.21", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01155455224.21"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pharmacy, The University of Tokyo Hospital, Faculty of Medicine, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.412708.8", 
              "name": [
                "Department of Pharmacy, The University of Tokyo Hospital, Faculty of Medicine, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Iga", 
            "givenName": "T.", 
            "id": "sg:person.01242657317.59", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01242657317.59"
            ], 
            "type": "Person"
          }
        ], 
        "datePublished": "1993-01", 
        "datePublishedReg": "1993-01-01", 
        "description": "We have studied the pharmacokinetics of methylphenidate enantiomers after the oral administration of different doses of racemic methylphenidate to one patient with narcolepsy and to four healthy volunteers.The plasma concentrations of (+)-methylphenidate were much higher than those of (\u2212)-methylphenidate after each dose in all subjects. In the patient the oral clearance (CL/f) of (+)-methylphenidate fell 3-fold and the area under the concentration-time curve (AUC) rose 7-fold when the dose was increased from 20 to 40 mg (from 0.27 to 0.53 mg\u00b7kg\u22121), in spite of the relatively constant terminal half-life of 2.6\u20132.7 h.Similar dose-dependency was also observed in the healthy volunteers in the dose range of 10\u201360 mg (0.12\u20130.77 mg\u00b7kg\u22121). The mean value of CL/f for the 40 mg dose was significantly lower than that for the 20 mg dose. The mean AUC of the (+)-isomer corrected to a dose of 10 mg increased significantly between the 20 mg and 40 mg doses.In the urine (+)- and (\u2212)-ritalinic acid were excreted for 48 h after each dose as 32\u201337% and 34\u201340% of the dose respectively. The mean total recoveries (sum of enantiomers of methylphenidate and its metabolite, ritalinic acid) in the urine were relatively constant (63\u201378% of the doses), suggesting that the changes in AUC with dose may not be due to a change in the intestinal absorption of racemic methylphenidate.We conclude that the nonlinear kinetics of (+)-methylphenidate may be due to saturation of its presystemic elimination.", 
        "genre": "article", 
        "id": "sg:pub.10.1007/bf00315285", 
        "inLanguage": "en", 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1054337", 
            "issn": [
              "0031-6970", 
              "1432-1041"
            ], 
            "name": "European Journal of Clinical Pharmacology", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "44"
          }
        ], 
        "keywords": [
          "healthy volunteers", 
          "racemic methylphenidate", 
          "concentration-time curve", 
          "CL/F", 
          "mean total recovery", 
          "oral clearance", 
          "presystemic elimination", 
          "methylphenidate enantiomers", 
          "plasma concentrations", 
          "oral administration", 
          "mean AUC", 
          "intestinal absorption", 
          "different doses", 
          "patients", 
          "dose", 
          "dose range", 
          "volunteers", 
          "narcolepsy", 
          "methylphenidate", 
          "doses", 
          "AUC", 
          "urine", 
          "nonlinear kinetics", 
          "total recovery", 
          "mean value", 
          "pharmacokinetics", 
          "administration", 
          "clearance", 
          "subjects", 
          "changes", 
          "recovery", 
          "elimination", 
          "concentration", 
          "spite", 
          "acid", 
          "enantiomers", 
          "saturation", 
          "area", 
          "curves", 
          "values", 
          "kinetics", 
          "absorption", 
          "range", 
          "threo-methylphenidate enantiomers"
        ], 
        "name": "Nonlinear kinetics of threo-methylphenidate enantiomers in a patient with narcolepsy and in healthy volunteers", 
        "pagination": "79-84", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1035164371"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/bf00315285"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "8436161"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/bf00315285", 
          "https://app.dimensions.ai/details/publication/pub.1035164371"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2021-12-01T19:08", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20211201/entities/gbq_results/article/article_239.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1007/bf00315285"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/bf00315285'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/bf00315285'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/bf00315285'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/bf00315285'


     

    This table displays all metadata directly associated to this object as RDF triples.

    180 TRIPLES      21 PREDICATES      80 URIs      72 LITERALS      16 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/bf00315285 schema:about N169e61e5e9094b96ae14e4b1148b68ed
    2 N427bacd0864046dc9340277142f8fd1c
    3 N72b3c808cbbe4dfd97d6c6581db49d87
    4 N97109765c42d4fdcb35ee1f4d807ce91
    5 Nc2d0c72d1648495aa8a7cd26388b7cef
    6 Nc39be872c38448f0ae10137e67f3fa48
    7 Nd5a0426df8654216bc2a2f58d85a308b
    8 Neaa2ea42ea1343d6822a9bb721fffc98
    9 Nf520795e81b14d1e841206ddad316672
    10 anzsrc-for:11
    11 anzsrc-for:1103
    12 schema:author Ne5bf7f74fd9944ca90d4d11e69a6d085
    13 schema:datePublished 1993-01
    14 schema:datePublishedReg 1993-01-01
    15 schema:description We have studied the pharmacokinetics of methylphenidate enantiomers after the oral administration of different doses of racemic methylphenidate to one patient with narcolepsy and to four healthy volunteers.The plasma concentrations of (+)-methylphenidate were much higher than those of (−)-methylphenidate after each dose in all subjects. In the patient the oral clearance (CL/f) of (+)-methylphenidate fell 3-fold and the area under the concentration-time curve (AUC) rose 7-fold when the dose was increased from 20 to 40 mg (from 0.27 to 0.53 mg·kg−1), in spite of the relatively constant terminal half-life of 2.6–2.7 h.Similar dose-dependency was also observed in the healthy volunteers in the dose range of 10–60 mg (0.12–0.77 mg·kg−1). The mean value of CL/f for the 40 mg dose was significantly lower than that for the 20 mg dose. The mean AUC of the (+)-isomer corrected to a dose of 10 mg increased significantly between the 20 mg and 40 mg doses.In the urine (+)- and (−)-ritalinic acid were excreted for 48 h after each dose as 32–37% and 34–40% of the dose respectively. The mean total recoveries (sum of enantiomers of methylphenidate and its metabolite, ritalinic acid) in the urine were relatively constant (63–78% of the doses), suggesting that the changes in AUC with dose may not be due to a change in the intestinal absorption of racemic methylphenidate.We conclude that the nonlinear kinetics of (+)-methylphenidate may be due to saturation of its presystemic elimination.
    16 schema:genre article
    17 schema:inLanguage en
    18 schema:isAccessibleForFree false
    19 schema:isPartOf N12c960a0271b47a48be464084cdd202b
    20 Nf62968ea181b41f988b0e3fd828995dc
    21 sg:journal.1054337
    22 schema:keywords AUC
    23 CL/F
    24 absorption
    25 acid
    26 administration
    27 area
    28 changes
    29 clearance
    30 concentration
    31 concentration-time curve
    32 curves
    33 different doses
    34 dose
    35 dose range
    36 doses
    37 elimination
    38 enantiomers
    39 healthy volunteers
    40 intestinal absorption
    41 kinetics
    42 mean AUC
    43 mean total recovery
    44 mean value
    45 methylphenidate
    46 methylphenidate enantiomers
    47 narcolepsy
    48 nonlinear kinetics
    49 oral administration
    50 oral clearance
    51 patients
    52 pharmacokinetics
    53 plasma concentrations
    54 presystemic elimination
    55 racemic methylphenidate
    56 range
    57 recovery
    58 saturation
    59 spite
    60 subjects
    61 threo-methylphenidate enantiomers
    62 total recovery
    63 urine
    64 values
    65 volunteers
    66 schema:name Nonlinear kinetics of threo-methylphenidate enantiomers in a patient with narcolepsy and in healthy volunteers
    67 schema:pagination 79-84
    68 schema:productId N2994ebd2178c48b4902b941812c75810
    69 Nc2bef6cdc33f479b99e1e18d5d0e00e1
    70 Nd66a89e64f8c41d1b09815f5ac32454e
    71 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035164371
    72 https://doi.org/10.1007/bf00315285
    73 schema:sdDatePublished 2021-12-01T19:08
    74 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    75 schema:sdPublisher N67faf92aac714f0ca913d81761712116
    76 schema:url https://doi.org/10.1007/bf00315285
    77 sgo:license sg:explorer/license/
    78 sgo:sdDataset articles
    79 rdf:type schema:ScholarlyArticle
    80 N03f11ed992d844e5a0190d176bcb161a rdf:first sg:person.01127405054.09
    81 rdf:rest N3b2342d0feb84bafbb1a4420396bb041
    82 N128a98f2f2114ce388509857c581f411 rdf:first sg:person.01242657317.59
    83 rdf:rest rdf:nil
    84 N12c960a0271b47a48be464084cdd202b schema:volumeNumber 44
    85 rdf:type schema:PublicationVolume
    86 N169e61e5e9094b96ae14e4b1148b68ed schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    87 schema:name Adult
    88 rdf:type schema:DefinedTerm
    89 N2994ebd2178c48b4902b941812c75810 schema:name pubmed_id
    90 schema:value 8436161
    91 rdf:type schema:PropertyValue
    92 N3b2342d0feb84bafbb1a4420396bb041 rdf:first sg:person.016005236422.74
    93 rdf:rest N9b2dbcb70a2d4088878f296987135c32
    94 N427bacd0864046dc9340277142f8fd1c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    95 schema:name Male
    96 rdf:type schema:DefinedTerm
    97 N67faf92aac714f0ca913d81761712116 schema:name Springer Nature - SN SciGraph project
    98 rdf:type schema:Organization
    99 N72b3c808cbbe4dfd97d6c6581db49d87 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    100 schema:name Humans
    101 rdf:type schema:DefinedTerm
    102 N97109765c42d4fdcb35ee1f4d807ce91 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    103 schema:name Narcolepsy
    104 rdf:type schema:DefinedTerm
    105 N9b2dbcb70a2d4088878f296987135c32 rdf:first sg:person.01270034754.54
    106 rdf:rest Nc5e0368469cd471cba18f3b22743223d
    107 Nc2bef6cdc33f479b99e1e18d5d0e00e1 schema:name doi
    108 schema:value 10.1007/bf00315285
    109 rdf:type schema:PropertyValue
    110 Nc2d0c72d1648495aa8a7cd26388b7cef schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    111 schema:name Methylphenidate
    112 rdf:type schema:DefinedTerm
    113 Nc39be872c38448f0ae10137e67f3fa48 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    114 schema:name Administration, Oral
    115 rdf:type schema:DefinedTerm
    116 Nc5e0368469cd471cba18f3b22743223d rdf:first sg:person.01155455224.21
    117 rdf:rest N128a98f2f2114ce388509857c581f411
    118 Nd5a0426df8654216bc2a2f58d85a308b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    119 schema:name Stereoisomerism
    120 rdf:type schema:DefinedTerm
    121 Nd66a89e64f8c41d1b09815f5ac32454e schema:name dimensions_id
    122 schema:value pub.1035164371
    123 rdf:type schema:PropertyValue
    124 Ne5bf7f74fd9944ca90d4d11e69a6d085 rdf:first sg:person.011206573461.15
    125 rdf:rest N03f11ed992d844e5a0190d176bcb161a
    126 Neaa2ea42ea1343d6822a9bb721fffc98 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    127 schema:name Aged
    128 rdf:type schema:DefinedTerm
    129 Nf520795e81b14d1e841206ddad316672 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    130 schema:name Female
    131 rdf:type schema:DefinedTerm
    132 Nf62968ea181b41f988b0e3fd828995dc schema:issueNumber 1
    133 rdf:type schema:PublicationIssue
    134 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    135 schema:name Medical and Health Sciences
    136 rdf:type schema:DefinedTerm
    137 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
    138 schema:name Clinical Sciences
    139 rdf:type schema:DefinedTerm
    140 sg:journal.1054337 schema:issn 0031-6970
    141 1432-1041
    142 schema:name European Journal of Clinical Pharmacology
    143 schema:publisher Springer Nature
    144 rdf:type schema:Periodical
    145 sg:person.011206573461.15 schema:affiliation grid-institutes:grid.412708.8
    146 schema:familyName Aoyama
    147 schema:givenName T.
    148 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011206573461.15
    149 rdf:type schema:Person
    150 sg:person.01127405054.09 schema:affiliation grid-institutes:grid.412708.8
    151 schema:familyName Kotaki
    152 schema:givenName H.
    153 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01127405054.09
    154 rdf:type schema:Person
    155 sg:person.01155455224.21 schema:affiliation grid-institutes:grid.419280.6
    156 schema:familyName Honda
    157 schema:givenName Y.
    158 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01155455224.21
    159 rdf:type schema:Person
    160 sg:person.01242657317.59 schema:affiliation grid-institutes:grid.412708.8
    161 schema:familyName Iga
    162 schema:givenName T.
    163 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01242657317.59
    164 rdf:type schema:Person
    165 sg:person.01270034754.54 schema:affiliation grid-institutes:grid.412708.8
    166 schema:familyName Sawada
    167 schema:givenName Y.
    168 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01270034754.54
    169 rdf:type schema:Person
    170 sg:person.016005236422.74 schema:affiliation grid-institutes:grid.419280.6
    171 schema:familyName Sasaki
    172 schema:givenName T.
    173 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016005236422.74
    174 rdf:type schema:Person
    175 grid-institutes:grid.412708.8 schema:alternateName Department of Pharmacy, The University of Tokyo Hospital, Faculty of Medicine, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo, Japan
    176 schema:name Department of Pharmacy, The University of Tokyo Hospital, Faculty of Medicine, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo, Japan
    177 rdf:type schema:Organization
    178 grid-institutes:grid.419280.6 schema:alternateName Neuropsychiatric Research Institute, Seiwa Hospital, Bentencho, Shinjuku-ku, Tokyo, Japan
    179 schema:name Neuropsychiatric Research Institute, Seiwa Hospital, Bentencho, Shinjuku-ku, Tokyo, Japan
    180 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...