Phenotypic identification of amplifications of the ADH4 and CUP1 genes of Saccharomyces cerevisiae View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1993-09

AUTHORS

Michael J. Dorsey, Paula Hoeh, Charlotte E. Paquin

ABSTRACT

Primary gene amplification, i.e., mutation from one gene copy to multiple gene copies per genome, is important in genomic evolution, as a means of producing anti-cancer drug resistance, and is associated with the progression of tumor malignancy. Primary amplification has not been studied in normal eukaryotic cells because amplifications are extremely rare in these cells. A system has been developed to phenotypically identify co-amplifications of the ADH4 and CUP1 genes of Saccharomyces cerevisiae and 21 independent spontaneous amplifications have been isolated. More... »

PAGES

392-396

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00312624

DOI

http://dx.doi.org/10.1007/bf00312624

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1044325003

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/8319294


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