Proposal of a risk score for recurrence in patients with curatively resected gastric cancer View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1993-09

AUTHORS

Takashi Ichikura, Keiichi Fujino, Hirotsugu Ikawa, Soichi Tomimatsu, Kazuhiko Uefuji, Shoetsu Tamakuma

ABSTRACT

In this study, 168 patients who underwent curative resection for gastric cancer with prognostic serosal invasion [ps(+)] and 150 without prognostic serosal invasion [ps(−)] were analyzed separately to determine the prognostic importance of clinicopathological factors, and identify which patients were at high risk of recurrence. A multivariate analysis of survival time using Cox's proportional hazard model revealed the important prognostic factors to be: Lymph node involvement, the classification of gross appearance, macroscopic serosal invasion, and interstitial connective tissue in the ps(+) group; and lymph node involvement, macroscopic serosal invasion, and venous invasion in the ps(−) group. We proposed a risk score of recurrence based on the results of a further multivariate analysis called Hayashi's Quantification Analysis II, in which recurrence was chosen as an objective variable and the above prognostic factors were chosen as explanatory variables. Eighty-four percent of the patients with a score of 0 or higher in the ps(+) group and 83% of those with a score of +6 or higher in the ps(−) group showed recurrence. Thus, we believe that this score is useful for identifying those patients at high risk of recurrence, who should receive intensive chemotherapy even after curative resection. More... »

PAGES

759-764

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00311616

DOI

http://dx.doi.org/10.1007/bf00311616

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1036378770

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/8219607


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