Anaplastic thyroid carcinoma producing the granulocyte colony stimulating factor (G-CSF): Report of a case View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1995-02

AUTHORS

Kazunori Iwasa, Masakuni Noguchi, Kazuhiro Mori, Nagayoshi Ohta, Itsuo Miyazaki, Akitaka Nonomura, Yuji Mizukami, Shinobu Nakamura, Takatoshi Michigishi

ABSTRACT

We report herein the unusual case of a 60-year-old woman with an anaplastic thyroid carcinoma which produced granulocyte colony stimulating factor (G-CSF). She presented with large neck masses, respiratory difficulty, and a high fever. Laboratory examinations revealed marked leukocytosis of 43,200/mm3 with 85% granulocytes and an elevated G-CSF level of 67 pg/dl. Total thyroidectomy with bilateral node dissection and tracheostomy was performed, and a histological diagnosis of large-cell anaplastic thyroid carcinoma was confirmed. Immunohistochemical examination with a polyclonal antibody against G-CSF stained the tumor cells. Although the respiratory difficulty, fever, and marked granulocytosis subsequently improved, she died 1 month after undergoing surgery due to metastatic mediastinal disease. More... »

PAGES

158-160

References to SciGraph publications

  • 1990-12. A case of gallbladder cancer producing granulocyte-colony-stimulating factor in JOURNAL OF GASTROENTEROLOGY
  • 1966-06. THE GROWTH OF MOUSE BONE MARROW CELLS IN VITRO in IMMUNOLOGY AND CELL BIOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/bf00311090

    DOI

    http://dx.doi.org/10.1007/bf00311090

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1007965189

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/7539648


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