Immunohistochemical identification of proteoglycan form of macrophage colony-stimulating factor on bone surface View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1995-09

AUTHORS

T. Ohtsuki, K. Hatake, S. Suzu, K. Saito, K. Motoyoshi, Y. Miura

ABSTRACT

Several studies using op/op mice have shown that macrophage colony-stimulating factor (M-CSF) was necessary for osteoclast formation in vivo. Previously we reported that osteoblastic cells produced two molecular forms of M-CSF; one is an 85-kDa M-CSF, and the other is a proteoglycan form of M-CSF (PG-M-CSF) which has a binding affinity for bone-derived collagens and is extractable from human bone. In this study, we performed immunostaining of human bone using a newly established anti-PG-M-CSF antibody, and showed positive staining PG-M-CSF, probably produced by bone lining cells, on the bone surface. This observation suggests that the bone surface is suitable for osteoclast formation because of the presence of PG-M-CSF. More... »

PAGES

213-217

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00310261

DOI

http://dx.doi.org/10.1007/bf00310261

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1004679540

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/8574939


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