Neuropathological stageing of Alzheimer-related changes View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1991-09

AUTHORS

H. Braak, E. Braak

ABSTRACT

Eighty-three brains obtained at autopsy from nondemented and demented individuals were examined for extracellular amyloid deposits and intraneuronal neurofibrillary changes. The distribution pattern and packing density of amyloid deposits turned out to be of limited significance for differentiation of neuropathological stages. Neurofibrillary changes occurred in the form of neuritic plaques, neurofibrillary tangles and neuropil threads. The distribution of neuritic plaques varied widely not only within architectonic units but also from one individual to another. Neurofibrillary tangles and neuropil threads, in contrast, exhibited a characteristic distribution pattern permitting the differentiation of six stages. The first two stages were characterized by an either mild or severe alteration of the transentorhinal layer Pre-α (transentorhinal stages I–II). The two forms of limbic stages (stages III–IV) were marked by a conspicuous affection of layer Pre-α in both transentorhinal region and proper entorhinal cortex. In addition, there was mild involvement of the first Ammon's horn sector. The hallmark of the two isocortical stages (stages V–VI) was the destruction of virtually all isocortical association areas. The investigation showed that recognition of the six stages required qualitative evaluation of only a few key preparations. More... »

PAGES

239-259

References to SciGraph publications

  • 1970-06. Quantitative histological studies on the aged human brain in ACTA NEUROPATHOLOGICA
  • 1990. Clinical diagnosis of Alzheimer’s disease: DSM-III-R, ICD-10 — what else? in ALZHEIMER’S DISEASE. EPIDEMIOLOGY, NEUROPATHOLOGY, NEUROCHEMISTRY, AND CLINICS
  • 1990-08. Ultrastructure of the neuropil threads in the Alzheimer brain: their dendritic origin and accumulation in the senile plaques in ACTA NEUROPATHOLOGICA
  • 1985-12. On areas of transition between entorhinal allocortex and temporal isocortex in the human brain. Normal morphology and lamina-specific pathology in Alzheimer's disease in ACTA NEUROPATHOLOGICA
  • 1988-11. A variety of cerebral amyloid deposits in the brains of the Alzheimer-type dementia demonstrated byβ protein immunostaining in ACTA NEUROPATHOLOGICA
  • 1991-02. Alzheimer's disease affects limbic nuclei of the thalamus in ACTA NEUROPATHOLOGICA
  • 1990. Morphology of the cerebral cortex in relation to Alzheimer’s dementia in ALZHEIMER’S DISEASE. EPIDEMIOLOGY, NEUROPATHOLOGY, NEUROCHEMISTRY, AND CLINICS
  • 1990-07. The prevalence of amyloid (A4) protein deposits within the cerebral and cerebellar cortex in Down's syndrome and Alzheimer's disease in ACTA NEUROPATHOLOGICA
  • 1989-09. Alzheimer's disease: areal and laminar pathology in the occipital isocortex in ACTA NEUROPATHOLOGICA
  • 1985. Senile Dementia of the Alzheimer Type: Diagnostic and Differential Diagnostic Features with Special Reference to Functional Assessment Staging in SENILE DEMENTIA OF THE ALZHEIMER TYPE
  • 1990-09. Neurofibrillary changes confined to the entorhinal region and an abundance of cortical amyloid in cases of presenile and senile dementia in ACTA NEUROPATHOLOGICA
  • Journal

    TITLE

    Acta Neuropathologica

    ISSUE

    4

    VOLUME

    82

    Related Patents

  • Methods For Diagnosing And Treating Alzheimer's Disease
  • Preventive And Therapeutic Vaccine For Stroke And Neurological Disorders
  • Antibodies To Tau And Methods Of Treatment Therewith
  • Therapeutic Use Of Diaminophenothiazines
  • Anti-Tau Antibodies And Methods Of Use
  • Benzoxazole Derivatives
  • Mirna-Based Universal Screening Test (Ust)
  • Protein-Based Therapy And Diagnosis Of Tau-Mediated Pathology In Alzheimer's Disease
  • Antibody Based Reagents That Specifically Recognize Toxic Oligomeric Forms Of Tau
  • Antibody-Based Methods Of Detecting And Treating Alzheimer's Disease
  • Antibody Treatment Of Alzheimer's And Related Diseases
  • Protein-Based Therapy And Diagnosis Of Tau-Mediated Pathology In Alzheimer's Disease
  • Methods Of Treating Brain Injury
  • Dihydropyridopyrrole Derivatives As Tau-Pet-Ligands
  • Protein-Based Therapy And Diagnosis Of Tau-Mediated Pathology In Alzheimer's Disease
  • Methods Of Treating Cognitive Impairment
  • Analysis Of Positron Emission Scans Using Descriptors Based On Fractal Analysis
  • Small Molecules For Imaging Protein-Protein Interactions
  • Antibodies To Tau And Uses Thereof
  • Use Of Cacybp/Sip In The Treatment And Diagnosis Of Alzheimer's Disease
  • Protein-Based Therapy And Diagnosis Of Tau-Mediated Pathology In Alzheimer's Disease
  • Heterocyclic Compounds As Imaging Probes Of Tau Pathology
  • Transgenic Pig As A Model Of Alzheimer's Disease
  • Novel Imaging Compounds
  • Agents Inhibiting Kallikrein-8 For Use In The Prevention Or Treatment Of Alzheimer's Disease
  • Method For Positron Emission Tomography (Pet) Imaging Analysis For Classifying And Diagnosing Of Neurological Diseases
  • Treatment Of Alzheimer's Disease
  • Dna Molecules Encoding Antibodies To Tau And Methods Of Making Thereof
  • Antibodies To Phosphorylated Tau Aggregates
  • Detection Of Tau
  • Methods Of Treating Cognitive Impairment
  • Aβ42 Lowering Agents
  • Specific Deep Brain Stimulation For Enhancement Of Memory
  • Methods Of Using Mirna From Bodily Fluids For Early Detection And Monitoring Of Mild Cognitive Impairment (Mci) And Alzheimer's Disease (Ad)
  • Antibodies Selective For Pathological Tau Dimers And Prefibrillar Pathological Tau Oligomers And Their Uses In Treatment, Diagnosis And Monitoring Of Tauopathies
  • A Peptide Or Collection Of Peptides Derived From Amyloid Precursor Protein
  • Combinational Fendiline Formulations And Uses Thereof
  • Ankyrin G And Modulators Thereof For The Treatment Of Neurodegenerative Disorders
  • Antibody Based Reagents That Specifically Recognize Toxic Oligomeric Forms Of Tau
  • Mirna-Based Methods For Detecting And Monitoring Aging
  • Inhibition Of Beta-2 Nicotinic Acetylcholine Receptors To Treat Alzheimer's Disease Pathology
  • Methods Of Using Mirna From Bodily Fluids For Early Detection And Monitoring Of Mild Cognitive Impairment (Mci) And Alzheimer's Disease (Ad)
  • Protein-Based Therapy And Diagnosis Of Tau-Mediated Pathology In Alzheimer's Disease Field
  • Site Specific Deep Brain Stimulation For Enhancement Of Memory
  • Method Of Detecting And Preventing Alzheimer's Disease, Particularly At Prodromal And Early Stages
  • Methods Of Diagnosing Diseases Caused By Or Associated With Neurofibrillary Tangles By Phosphospecific Antibodies Recognising Tau
  • Methods Of Treating Cognitive Impairment
  • Immunization With Amyloid-Beta Oligomers
  • Methods For Multi-Dose Synthesis Of [F-18]Fddnp For Clinical Settings
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/bf00308809

    DOI

    http://dx.doi.org/10.1007/bf00308809

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1000355620

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/1759558


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Clinical Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Neurosciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Aged, 80 and over", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Alzheimer Disease", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Amyloid", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Brain", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Histocytochemistry", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Middle Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neurites", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neurofibrillary Tangles", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Zentrum der Morphologie, Theodor-Stern-Kai 7, W-6000, Frankfurt/Main 70, Germany", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Zentrum der Morphologie, Theodor-Stern-Kai 7, W-6000, Frankfurt/Main 70, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Braak", 
            "givenName": "H.", 
            "id": "sg:person.01053255500.71", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01053255500.71"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Zentrum der Morphologie, Theodor-Stern-Kai 7, W-6000, Frankfurt/Main 70, Germany", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Zentrum der Morphologie, Theodor-Stern-Kai 7, W-6000, Frankfurt/Main 70, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Braak", 
            "givenName": "E.", 
            "id": "sg:person.01365302117.15", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01365302117.15"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1007/bf00294651", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038733783", 
              "https://doi.org/10.1007/bf00294651"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00294607", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026615032", 
              "https://doi.org/10.1007/bf00294607"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00305867", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019847482", 
              "https://doi.org/10.1007/bf00305867"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00689591", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047623814", 
              "https://doi.org/10.1007/bf00689591"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00687251", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021432159", 
              "https://doi.org/10.1007/bf00687251"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-3-7091-3396-5_8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001702440", 
              "https://doi.org/10.1007/978-3-7091-3396-5_8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00687663", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007759618", 
              "https://doi.org/10.1007/bf00687663"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-3-642-70644-8_2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041139942", 
              "https://doi.org/10.1007/978-3-642-70644-8_2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00307689", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048537601", 
              "https://doi.org/10.1007/bf00307689"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-3-7091-3396-5_41", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034080131", 
              "https://doi.org/10.1007/978-3-7091-3396-5_41"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00690836", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027229539", 
              "https://doi.org/10.1007/bf00690836"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "1991-09", 
        "datePublishedReg": "1991-09-01", 
        "description": "Eighty-three brains obtained at autopsy from nondemented and demented individuals were examined for extracellular amyloid deposits and intraneuronal neurofibrillary changes. The distribution pattern and packing density of amyloid deposits turned out to be of limited significance for differentiation of neuropathological stages. Neurofibrillary changes occurred in the form of neuritic plaques, neurofibrillary tangles and neuropil threads. The distribution of neuritic plaques varied widely not only within architectonic units but also from one individual to another. Neurofibrillary tangles and neuropil threads, in contrast, exhibited a characteristic distribution pattern permitting the differentiation of six stages. The first two stages were characterized by an either mild or severe alteration of the transentorhinal layer Pre-\u03b1 (transentorhinal stages I\u2013II). The two forms of limbic stages (stages III\u2013IV) were marked by a conspicuous affection of layer Pre-\u03b1 in both transentorhinal region and proper entorhinal cortex. In addition, there was mild involvement of the first Ammon's horn sector. The hallmark of the two isocortical stages (stages V\u2013VI) was the destruction of virtually all isocortical association areas. The investigation showed that recognition of the six stages required qualitative evaluation of only a few key preparations.", 
        "genre": "article", 
        "id": "sg:pub.10.1007/bf00308809", 
        "inLanguage": "en", 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1019073", 
            "issn": [
              "0001-6322", 
              "1432-0533"
            ], 
            "name": "Acta Neuropathologica", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "4", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "82"
          }
        ], 
        "keywords": [
          "neuritic plaques", 
          "neurofibrillary changes", 
          "amyloid deposits", 
          "intraneuronal neurofibrillary changes", 
          "isocortical association areas", 
          "extracellular amyloid deposits", 
          "limbic stage", 
          "isocortical stages", 
          "transentorhinal region", 
          "neuropil threads", 
          "mild involvement", 
          "neuropathological stages", 
          "neurofibrillary tangles", 
          "association areas", 
          "severe alterations", 
          "plaques", 
          "characteristic distribution pattern", 
          "pre", 
          "qualitative evaluation", 
          "individuals", 
          "brain", 
          "differentiation", 
          "tangles", 
          "limited significance", 
          "Alzheimer's", 
          "alterations", 
          "changes", 
          "distribution patterns", 
          "hallmark", 
          "involvement", 
          "stage", 
          "patterns", 
          "destruction", 
          "significance", 
          "affection", 
          "key preparation", 
          "evaluation", 
          "contrast", 
          "addition", 
          "form", 
          "units", 
          "investigation", 
          "preparation", 
          "area", 
          "recognition", 
          "region", 
          "deposits", 
          "distribution", 
          "density", 
          "threads", 
          "packing density", 
          "sector", 
          "architectonic units", 
          "transentorhinal layer Pre", 
          "layer Pre", 
          "conspicuous affection", 
          "first Ammon's horn sector", 
          "Ammon's horn sector", 
          "'s horn sector", 
          "Neuropathological stageing", 
          "stageing"
        ], 
        "name": "Neuropathological stageing of Alzheimer-related changes", 
        "pagination": "239-259", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1000355620"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/bf00308809"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "1759558"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/bf00308809", 
          "https://app.dimensions.ai/details/publication/pub.1000355620"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-01-01T18:05", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20220101/entities/gbq_results/article/article_228.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1007/bf00308809"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/bf00308809'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/bf00308809'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/bf00308809'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/bf00308809'


     

    This table displays all metadata directly associated to this object as RDF triples.

    226 TRIPLES      22 PREDICATES      112 URIs      92 LITERALS      19 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/bf00308809 schema:about N0138d2b0d90d4f02ac77591f1abef302
    2 N0d01eb68247c4582902d74345da031f8
    3 N0d9bbdafbe734c98b0fc329c07795ae6
    4 N1b8c47fccb3748239297f738a318afe1
    5 N2fbf8cf09b004f4a947569535b2e5edb
    6 N6c7fa745de584856814e72693f3286c5
    7 N70768ec5f5454cc79ac8c6c723f7f398
    8 N7586ce6a2859483cbaf62aae1c83e558
    9 N932fa70e1c314891b4ad4f050f1305b9
    10 Ne3426d4c67a1409f98a25e59b83d5b08
    11 Nec617dd4c2284cda9de8ca30110547ab
    12 Nf904eacaf91a4954980a9284193276d4
    13 anzsrc-for:11
    14 anzsrc-for:1103
    15 anzsrc-for:1109
    16 schema:author N9bee81057f4548d49d764e84f301469a
    17 schema:citation sg:pub.10.1007/978-3-642-70644-8_2
    18 sg:pub.10.1007/978-3-7091-3396-5_41
    19 sg:pub.10.1007/978-3-7091-3396-5_8
    20 sg:pub.10.1007/bf00294607
    21 sg:pub.10.1007/bf00294651
    22 sg:pub.10.1007/bf00305867
    23 sg:pub.10.1007/bf00307689
    24 sg:pub.10.1007/bf00687251
    25 sg:pub.10.1007/bf00687663
    26 sg:pub.10.1007/bf00689591
    27 sg:pub.10.1007/bf00690836
    28 schema:datePublished 1991-09
    29 schema:datePublishedReg 1991-09-01
    30 schema:description Eighty-three brains obtained at autopsy from nondemented and demented individuals were examined for extracellular amyloid deposits and intraneuronal neurofibrillary changes. The distribution pattern and packing density of amyloid deposits turned out to be of limited significance for differentiation of neuropathological stages. Neurofibrillary changes occurred in the form of neuritic plaques, neurofibrillary tangles and neuropil threads. The distribution of neuritic plaques varied widely not only within architectonic units but also from one individual to another. Neurofibrillary tangles and neuropil threads, in contrast, exhibited a characteristic distribution pattern permitting the differentiation of six stages. The first two stages were characterized by an either mild or severe alteration of the transentorhinal layer Pre-α (transentorhinal stages I–II). The two forms of limbic stages (stages III–IV) were marked by a conspicuous affection of layer Pre-α in both transentorhinal region and proper entorhinal cortex. In addition, there was mild involvement of the first Ammon's horn sector. The hallmark of the two isocortical stages (stages V–VI) was the destruction of virtually all isocortical association areas. The investigation showed that recognition of the six stages required qualitative evaluation of only a few key preparations.
    31 schema:genre article
    32 schema:inLanguage en
    33 schema:isAccessibleForFree false
    34 schema:isPartOf N06a67d4b048f4137b40138a19999ad5c
    35 Nd24ee4a4aa4545ec894880e3d4c8a58b
    36 sg:journal.1019073
    37 schema:keywords 's horn sector
    38 Alzheimer's
    39 Ammon's horn sector
    40 Neuropathological stageing
    41 addition
    42 affection
    43 alterations
    44 amyloid deposits
    45 architectonic units
    46 area
    47 association areas
    48 brain
    49 changes
    50 characteristic distribution pattern
    51 conspicuous affection
    52 contrast
    53 density
    54 deposits
    55 destruction
    56 differentiation
    57 distribution
    58 distribution patterns
    59 evaluation
    60 extracellular amyloid deposits
    61 first Ammon's horn sector
    62 form
    63 hallmark
    64 individuals
    65 intraneuronal neurofibrillary changes
    66 investigation
    67 involvement
    68 isocortical association areas
    69 isocortical stages
    70 key preparation
    71 layer Pre
    72 limbic stage
    73 limited significance
    74 mild involvement
    75 neuritic plaques
    76 neurofibrillary changes
    77 neurofibrillary tangles
    78 neuropathological stages
    79 neuropil threads
    80 packing density
    81 patterns
    82 plaques
    83 pre
    84 preparation
    85 qualitative evaluation
    86 recognition
    87 region
    88 sector
    89 severe alterations
    90 significance
    91 stage
    92 stageing
    93 tangles
    94 threads
    95 transentorhinal layer Pre
    96 transentorhinal region
    97 units
    98 schema:name Neuropathological stageing of Alzheimer-related changes
    99 schema:pagination 239-259
    100 schema:productId N256b71320efb4652b5c162d4ecb8b0fd
    101 N5880ef62997249a1b18f9322466630c0
    102 N998e87512e4d4db1a4c4d4c6476908c1
    103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000355620
    104 https://doi.org/10.1007/bf00308809
    105 schema:sdDatePublished 2022-01-01T18:05
    106 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    107 schema:sdPublisher N54de79e7c47645718a29962feec22b83
    108 schema:url https://doi.org/10.1007/bf00308809
    109 sgo:license sg:explorer/license/
    110 sgo:sdDataset articles
    111 rdf:type schema:ScholarlyArticle
    112 N0138d2b0d90d4f02ac77591f1abef302 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    113 schema:name Female
    114 rdf:type schema:DefinedTerm
    115 N06a67d4b048f4137b40138a19999ad5c schema:issueNumber 4
    116 rdf:type schema:PublicationIssue
    117 N0d01eb68247c4582902d74345da031f8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    118 schema:name Histocytochemistry
    119 rdf:type schema:DefinedTerm
    120 N0d9bbdafbe734c98b0fc329c07795ae6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    121 schema:name Aged
    122 rdf:type schema:DefinedTerm
    123 N1b8c47fccb3748239297f738a318afe1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    124 schema:name Aged, 80 and over
    125 rdf:type schema:DefinedTerm
    126 N256b71320efb4652b5c162d4ecb8b0fd schema:name pubmed_id
    127 schema:value 1759558
    128 rdf:type schema:PropertyValue
    129 N2fbf8cf09b004f4a947569535b2e5edb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    130 schema:name Alzheimer Disease
    131 rdf:type schema:DefinedTerm
    132 N54de79e7c47645718a29962feec22b83 schema:name Springer Nature - SN SciGraph project
    133 rdf:type schema:Organization
    134 N5880ef62997249a1b18f9322466630c0 schema:name dimensions_id
    135 schema:value pub.1000355620
    136 rdf:type schema:PropertyValue
    137 N5f2715b2935e4a9b8774f8429dd7a8a2 rdf:first sg:person.01365302117.15
    138 rdf:rest rdf:nil
    139 N6c7fa745de584856814e72693f3286c5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    140 schema:name Humans
    141 rdf:type schema:DefinedTerm
    142 N70768ec5f5454cc79ac8c6c723f7f398 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    143 schema:name Brain
    144 rdf:type schema:DefinedTerm
    145 N7586ce6a2859483cbaf62aae1c83e558 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    146 schema:name Middle Aged
    147 rdf:type schema:DefinedTerm
    148 N932fa70e1c314891b4ad4f050f1305b9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    149 schema:name Neurofibrillary Tangles
    150 rdf:type schema:DefinedTerm
    151 N998e87512e4d4db1a4c4d4c6476908c1 schema:name doi
    152 schema:value 10.1007/bf00308809
    153 rdf:type schema:PropertyValue
    154 N9bee81057f4548d49d764e84f301469a rdf:first sg:person.01053255500.71
    155 rdf:rest N5f2715b2935e4a9b8774f8429dd7a8a2
    156 Nd24ee4a4aa4545ec894880e3d4c8a58b schema:volumeNumber 82
    157 rdf:type schema:PublicationVolume
    158 Ne3426d4c67a1409f98a25e59b83d5b08 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    159 schema:name Amyloid
    160 rdf:type schema:DefinedTerm
    161 Nec617dd4c2284cda9de8ca30110547ab schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    162 schema:name Neurites
    163 rdf:type schema:DefinedTerm
    164 Nf904eacaf91a4954980a9284193276d4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    165 schema:name Male
    166 rdf:type schema:DefinedTerm
    167 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    168 schema:name Medical and Health Sciences
    169 rdf:type schema:DefinedTerm
    170 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
    171 schema:name Clinical Sciences
    172 rdf:type schema:DefinedTerm
    173 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
    174 schema:name Neurosciences
    175 rdf:type schema:DefinedTerm
    176 sg:journal.1019073 schema:issn 0001-6322
    177 1432-0533
    178 schema:name Acta Neuropathologica
    179 schema:publisher Springer Nature
    180 rdf:type schema:Periodical
    181 sg:person.01053255500.71 schema:affiliation grid-institutes:None
    182 schema:familyName Braak
    183 schema:givenName H.
    184 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01053255500.71
    185 rdf:type schema:Person
    186 sg:person.01365302117.15 schema:affiliation grid-institutes:None
    187 schema:familyName Braak
    188 schema:givenName E.
    189 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01365302117.15
    190 rdf:type schema:Person
    191 sg:pub.10.1007/978-3-642-70644-8_2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041139942
    192 https://doi.org/10.1007/978-3-642-70644-8_2
    193 rdf:type schema:CreativeWork
    194 sg:pub.10.1007/978-3-7091-3396-5_41 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034080131
    195 https://doi.org/10.1007/978-3-7091-3396-5_41
    196 rdf:type schema:CreativeWork
    197 sg:pub.10.1007/978-3-7091-3396-5_8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001702440
    198 https://doi.org/10.1007/978-3-7091-3396-5_8
    199 rdf:type schema:CreativeWork
    200 sg:pub.10.1007/bf00294607 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026615032
    201 https://doi.org/10.1007/bf00294607
    202 rdf:type schema:CreativeWork
    203 sg:pub.10.1007/bf00294651 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038733783
    204 https://doi.org/10.1007/bf00294651
    205 rdf:type schema:CreativeWork
    206 sg:pub.10.1007/bf00305867 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019847482
    207 https://doi.org/10.1007/bf00305867
    208 rdf:type schema:CreativeWork
    209 sg:pub.10.1007/bf00307689 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048537601
    210 https://doi.org/10.1007/bf00307689
    211 rdf:type schema:CreativeWork
    212 sg:pub.10.1007/bf00687251 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021432159
    213 https://doi.org/10.1007/bf00687251
    214 rdf:type schema:CreativeWork
    215 sg:pub.10.1007/bf00687663 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007759618
    216 https://doi.org/10.1007/bf00687663
    217 rdf:type schema:CreativeWork
    218 sg:pub.10.1007/bf00689591 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047623814
    219 https://doi.org/10.1007/bf00689591
    220 rdf:type schema:CreativeWork
    221 sg:pub.10.1007/bf00690836 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027229539
    222 https://doi.org/10.1007/bf00690836
    223 rdf:type schema:CreativeWork
    224 grid-institutes:None schema:alternateName Zentrum der Morphologie, Theodor-Stern-Kai 7, W-6000, Frankfurt/Main 70, Germany
    225 schema:name Zentrum der Morphologie, Theodor-Stern-Kai 7, W-6000, Frankfurt/Main 70, Germany
    226 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...