In vitro Sensibilitätstestung von Tumoren gegenüber aktiviertem Cyclophosphamid (4-Hydroxycyclophosphamid). Kurzzeitinkubation von Originaltumorzellen und 3H-Uridinbzw. 3H-Thymidineinbau View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1975-01

AUTHORS

G. Bastert, H. Schmidt-Matthiesen, G. Voelcker, G. Peter, H. J. Hohorst

ABSTRACT

A new in vitro assay for screening the sensitivity of human tumour cells against Cyclophosphamide has been developed. While biologically activated Cyclophosphamide was unsuitable because of unpurities in the material, synthetic 4-Hydroxycyclophosphamide was shown to inhibit the incorporation of tritiated uridine and thymidine into the nucleic acids of human tumour cells in vitro. 29 tumours including 14 mammarial carcinomas, 8 ovarial carcinomas and 7 other malignant tumours were tested. While 12 tumours showed a significant and 5 only a slight inhibition of the 3H-uridine incorporation in vitro. 12 tumours showed no effect. Histologically none-differentiated tumours were more sensitive against 4-Hydroxycyclophosphamide as compared with the more differentiated ones. First observations point to 4-Hydroperoxycyclophosphamide instead of 4-Hydroxycyclophosphamide as a more suitable form of activated Cyclophosphamid for the in vitro assay of Cyclophosphamide sensitiveness because of the higher stability and better availability of this compound. More... »

PAGES

37-47

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00305687

DOI

http://dx.doi.org/10.1007/bf00305687

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1004147226

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/171866


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45 schema:description A new in vitro assay for screening the sensitivity of human tumour cells against Cyclophosphamide has been developed. While biologically activated Cyclophosphamide was unsuitable because of unpurities in the material, synthetic 4-Hydroxycyclophosphamide was shown to inhibit the incorporation of tritiated uridine and thymidine into the nucleic acids of human tumour cells in vitro. 29 tumours including 14 mammarial carcinomas, 8 ovarial carcinomas and 7 other malignant tumours were tested. While 12 tumours showed a significant and 5 only a slight inhibition of the 3H-uridine incorporation in vitro. 12 tumours showed no effect. Histologically none-differentiated tumours were more sensitive against 4-Hydroxycyclophosphamide as compared with the more differentiated ones. First observations point to 4-Hydroperoxycyclophosphamide instead of 4-Hydroxycyclophosphamide as a more suitable form of activated Cyclophosphamid for the in vitro assay of Cyclophosphamide sensitiveness because of the higher stability and better availability of this compound.
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