Spontaneous variations in the cell population of a T-cell lymphoma during tissue culture and transplantation View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1975-01

AUTHORS

G. R. F. Krueger, H. -E. Schaefer, J. Luetzeler, R. Fischer, V. Kresin

ABSTRACT

Immunologically induced T-cell lymphomas were kept for long periods of time in isotransplantation and in tissue culture. Initially, a certain number of cells within the tumor showed differentiation towards histiocytes. These disappeared completely after about the twentieth graft generation when the tumor changed toward a more atypical and more uniform neoplasm. That change was correlated with a decrease in transplantability, a limited growth in tissue culture, and a decrease in density of theta antigens on tumor cell membranes. While the original tumor and early grafts contained occasional C-type particles, these were never demonstrated in late tumor grafts. The possible implications of these changes are discussed. More... »

PAGES

25-35

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00305686

DOI

http://dx.doi.org/10.1007/bf00305686

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1025196444

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/171865


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