Ontology type: schema:ScholarlyArticle
1973-06
AUTHORSJ. Vielkind, U. Vielkind, F. Anders
ABSTRACTExplants from genetically determined melanotic and amelanotic melanomas of platyfish-swordtail hybrids were cultivated in H3-thymidine-containing medium with or without additional amounts of amino acids. The incorporation of label into the DNA extracted from the explants was measured, and the DNA content per unit protein was determined. The results revealed a significant difference between the two melanoma types; the rate of DNA synthesis as well as the DNA to protein ratio of amelanotic melanoma explants was about twice that of melanotic ones. This is consistent with the results of earlier investigations which had shown that the amelanotic melanomas grow more rapidly and contain more incompletely differentiated cells than the melanotic ones. The data, furthermore, demonstrated that both melanoma types exhibit extreme individual variations in DNA synthesis and in the DNA to protein ratio. The present study failed to confirm the results of earlier autoradiographic studies which suggested that additional amounts of amino acids in the culture medium stimulate the incorporation of labeled thymidine into the melanoma DNA. The results of the present experiments on melanomas in vitro do not rule out the possibility that amino acids stimulate melanoma growth in vivo by initiating DNA synthesis and cell division of melanoma cells. More... »
PAGES103-112
http://scigraph.springernature.com/pub.10.1007/bf00305129
DOIhttp://dx.doi.org/10.1007/bf00305129
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