Action potential duration and force-frequency relationship in isolated rabbit, guinea pig and rat cardiac muscle View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1996-06

AUTHORS

P. Szigligeti, C. Pankucsi, T. Bányász, A. Varró, P. P. Nánási

ABSTRACT

The effect of action potential duration and elevated cytosolic sodium concentration on the forcefrequency relationship in isolated rabbit, guinea pig and rat papillary muscle preparations was studied. Shortening of action potential duration in guinea pig and rabbit from 150–200 ms to values characteristic of rat (20–40 ms), using the K(ATP) channel activator levkromakalim (15 μmol·l−1), markedly reduced the force of contraction and converted the positive force-frequency relationship into negative one at longer pacing cycle lengths. This conversion was greatly enhanced in the presence of acetylstrophanthidin (0.2–1 μmol·l−1), an inhibitor of the Na-K pump. Acetylstrophanthidin (1 μmol·l−1) alone, however, had no effect on the forcefrequency relationship. Prolongation of action potential duration in rat with inhibitors of cardiac K channels (4-aminopyridine [10 mmol·l−1] plus tetraethylammonium [2 mmol·l−1) increased the force of contraction and abolished the negative force-frequency relationship observed in rat at longer pacing-cycle lengths. It is concluded that both action potential duration and cytosolic sodium concentration are major determinants of the force-frequency relationship in mammalian myocardium. More... »

PAGES

150-155

References to SciGraph publications

  • 1989-09. Potassium channel openers act through an activation of ATP-sensitive K+ channels in guinea-pig cardiac myocytes in PFLÜGERS ARCHIV - EUROPEAN JOURNAL OF PHYSIOLOGY
  • 1968-03. The effect of the duration of the action potential on contraction in the mammalian heart muscle in PFLÜGERS ARCHIV - EUROPEAN JOURNAL OF PHYSIOLOGY
  • 1974-12. Effect of intracellular tetraethylammonium ion on action potential in the guinea-pig's myocardium in PFLÜGERS ARCHIV - EUROPEAN JOURNAL OF PHYSIOLOGY
  • 1979-03. The steady state TTX-sensitive (“window”) sodium current in cardiac Purkinje fibres in PFLÜGERS ARCHIV - EUROPEAN JOURNAL OF PHYSIOLOGY
  • 1987-01. Slow inactivation of the sodium current in rabbit cardiac Purkinje fibres in PFLÜGERS ARCHIV - EUROPEAN JOURNAL OF PHYSIOLOGY
  • 1983. Tetraethylammonium ions and the potassium permeability of excitable cells in REVIEWS OF PHYSIOLOGY, BIOCHEMISTRY AND PHARMACOLOGY, VOLUME 94
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/bf00301179

    DOI

    http://dx.doi.org/10.1007/bf00301179

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1033657246

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/8766913


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