Prognostic value of 123-IODO-heptadecanoic acid imaging in patients with acute myocardial infarction View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1987-02

AUTHORS

P. Gavin P. Stoddart, Mark Papouchado, Peter Wilde

ABSTRACT

This trial aimed to test if the half life of radioiodinated heptadecanoic acid (HDA) in acutely infarcted myocardium is of prognostic value. Twenty patients had an HDA scan and a MUGA scan within 6 days of acute myocardial infarction, eighteen of these had a visible defect on the HDA images. The mean half life of the areas of acute infarction (15.50 min +/- 7.82 min) was significantly shorter than that of normal myocardium (20.77 min +/- 4.00 min). The MUGA scan was repeated after 6 months in 15 patients. The mean acute infarct half life was longer in patients with an LVEF improvement of at least 5% at 6 months (16.92 min +/- 10.56 min), compared to those with a deterioration of more than 5% (11.75 min +/- 4.03 min), although the difference is not statistically significant. While the results in a few individuals suggested that the half life may be of prognostic significance, the variable response of the group reduced the ability of the half life to act as a prognostic indicator. Improvements in imaging and background subtraction techniques may be necessary before the half life is of practical value. More... »

PAGES

525-528

References to SciGraph publications

  • 1983-05. Myocardial kinetics of 123I-labeled-16-hexadecanoic acid in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • 1985-02. The myocardial elimination rate of radioiodinated heptadecanoic acid in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • 1981-09. Metabolic myocardial imaging with 123I-labeled heptadecanoic acid in patients with angina pectoris in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • 1985-09. The elimination rate of 123I-heptadecanoic acid after intracoronary and intravenous administration in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • 1984-07. ω-Halofatty acids: A probe for mitochondrial membrane integrity in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • 1981-09. Dynamic myocardial scintigraphy with 123I-labeled free fatty acids in patients with myocardial infarction in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/bf00296090

    DOI

    http://dx.doi.org/10.1007/bf00296090

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1010956185

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/3552688


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