Hereditary hypotrophic axonopathy with neurofilament deficiency in a mutant strain of the Japanese quail View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1991-11

AUTHORS

H. Yamasaki, C. Itakura, M. Mizutani

ABSTRACT

A primary axonal disease affecting the central and peripheral nervous system was discovered in a new mutant strain of the Japanese quail, named quiver (Quv). Quv showed significantly smaller cross-sectional areas of the cervical spinal cord and the optic and sciatic nerves, when compared with controls by light microscopic morphometry. In the cervical spinal cord, electron microscopic morphometry indicated that myelinated axons in Quv were significantly smaller in size than in controls, though greater in density. The axonal circularity was not significantly different from that of controls. Electron microscopically and immunohistochemically, neurofilaments were not detected in the axons or neuronal cell bodies. Axons in Quv were composed mainly of microtubules, which were increased in number in relation to the axonal size. From these findings, the lesions observed in Quv were regarded as axonal hypotrophy (growth arrest or retardation) due to altered neurofilament expression. More... »

PAGES

427-434

References to SciGraph publications

  • 1990. Neurofilaments in CELLULAR AND MOLECULAR BIOLOGY OF INTERMEDIATE FILAMENTS
  • 1986-03. Computer editing of morphometric data on nerve fibers. An improved computer program in ACTA NEUROPATHOLOGICA
  • 1987-03. Adaptation of the myelin sheath during axonal atrophy in ACTA NEUROPATHOLOGICA
  • 1980-01-17. Intermediate filaments as mechanical integrators of cellular space in NATURE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/bf00293376

    DOI

    http://dx.doi.org/10.1007/bf00293376

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1044792870

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/1785256


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