High-dose cyclophosphamide with autologous marrow transplantation as initial treatment of small cell carcinoma of the bronchus View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1982-04

AUTHORS

R. L. Souhami, P. G. Harper, D. Linch, C. Trask, A. H. Goldstone, J. Tobias, S. G. Spiro, D. M. Geddes, J. D. M. Richards

ABSTRACT

Sixteen patients with untreated small cell carcinoma of the bronchus received cyclophosphamide in a total dose of 160-200 mg/kg. Autologous marrow transplantation was used to minimise the period of hypoplasia and 2-mercaptoethane sulphonate to prevent urothelial toxicity. The procedure was well tolerated, with predictable and manageable toxicity. Complete radiological and bronchoscopic response was achieved in seven patients and partial response in a further seven. High-dose cyclophosphamide may be a useful initial treatment for this disease. More... »

PAGES

31-34

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00292868

DOI

http://dx.doi.org/10.1007/bf00292868

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1049703229

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/6284395


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