5-Azacytidine-induced undercondensations in human chromosomes View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1984-08

AUTHORS

M. Schmid, T. Haaf, D. Grunert

ABSTRACT

The cytosine analogue 5-azacytidine induces very distinct undercondensations in human chromosomes if applied to lymphocyte cultures. The number of induced undercondensations and their chromosomal localization can be varied by the 5-azacytidine dose and the treatment time. "Pulverized" chromosomes or undercondensations in the G-band-positive chromosome regions are produced with high doses and long treatment times. If applied in low doses during the last hours of culture, 5-azacytidine induces specific undercondensations in the heterochromatin of chromosomes 1, 9, 15, 16, and Y. Optimum conditions required for inducing the various types of undercondensation in the chromosomes were determined. Various examples of the use of 5-azacytidine in the analysis of chromosome rearrangements involving heterochromatic regions are presented. More... »

PAGES

257-263

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00291352

DOI

http://dx.doi.org/10.1007/bf00291352

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1037058742

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/6205969


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