Assignment of the human fast skeletal muscle myosin alkali light chains gene (MLC1F/MLC3F) to 2q 32.1-2qter View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1988-01

AUTHORS

Odile Cohen-Haguenauer, Paul J. R. Barton, Nguyen Van Cong, Stéphane Serero, Marie-Sylvie Gross, Chantal Jegou-Foubert, Marie-France de Tand, Benoit Robert, Margaret Buckingham, Jean Frézal

ABSTRACT

A DNA probe derived from a mouse intronless pseudogene including coding regions for the myosin fast skeletal muscle alkali light chains, MLC1F/MLC3F (suggested HGM symbol, MYL1), was tested on a panel of 25 independent man-rodent somatic cell hybrids in order to assign the human MLC1F/MLC3F gene to a human chromosome. A 3.7-kb TaqI human fragment was found to correlate with the presence of chromosome 2 in the hybrids, characterized both by cytogenetic analysis and reference enzyme markers. A regional assignment to 2q32.1-qter was possible using hybrids whose human parental strains bore a reciprocal translocation t(X;2) (p22;q32.1). The fact that IDH1 and the MLC1F/MLC3F gene are closely linked on chromosome 1 in the mouse and map to the same region of human chromosome 2 in man indicates, that these chromosomes have a conserved region of homology between them and that the human 3.7-kb TaqI fragment corresponds indeed to a functional gene. More... »

PAGES

65-70

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00291237

DOI

http://dx.doi.org/10.1007/bf00291237

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1004121850

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/3422212


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