Homology-dependent gene silencing in transgenic plants: epistatic silencing loci contain multiple copies of methylated transgenes View Full Text


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Article Info

DATE

1994-05

AUTHORS

A. J. M. Matzke, F. Neuhuber, Y. D. Park, P. F. Ambros, M. A. Matzke

ABSTRACT

Previous work has shown that two homologous, unlinked transgene loci can interact in plant nuclei, leading to non-reciprocal trans-inactivation and methylation of genes at one locus. Here, we report the structure and methylation of different transgene loci that contain the same construct but are variably able to inactivate and methylate a partially homologous, unlinked target locus. Silencing loci comprised multiple, methylated copies of the transgene construct, whereas a non-silencing locus contained a single, unmethylated copy. The correspondence between strength of silencing activity and copy number/degree of methylation was further demonstrated by producing novel alleles of a strong silencing locus: reducing the transgene copy number and methylation within this silencing locus decreased its ability to inactivate the target locus. The strong silencing locus, which was located close to a telomere, trans-inactivated various structural variants of the original target construct, regardless of their location in the genome. This suggests that the silencing locus can scan the entire genome for homologous regions, a process possibly aided by its telomeric location. Our data support the idea that epistatic trans-inactivation of unlinked, homologous transgenes in plants results from a pre-existing epigenetic difference between transgene loci, which is subsequently equalized by “epigene conversion” involving DNA-DNA pairing. More... »

PAGES

219-229

References to SciGraph publications

  • 1991-08. Reversible inactivation of a transgene in Arabidopsis thaliana in MOLECULAR GENETICS AND GENOMICS
  • 1987-05. T-DNA structure and gene expression in petunia plants transformed by Agrobacterium tumefaciens C58 derivatives in MOLECULAR GENETICS AND GENOMICS
  • 1990-07. Epigenetic changes in the expression of the maize A1 gene inPetunia hybrida: Role of numbers of integrated gene copies and state of methylation in MOLECULAR GENETICS AND GENOMICS
  • 1982-02. Substrate and sequence specificity of a eukaryotic DNA methylase in NATURE
  • 1991. Telomeric location of retroviral oncogenes in humans in HEREDITAS
  • 1993-01. Transgene copy number can be positively or negatively associated with transgene expression in PLANT MOLECULAR BIOLOGY
  • 1993-01. A variety of epistatic interactions can occur between partially homologous transgene loci brought together by sexual crossing in MOLECULAR GENETICS AND GENOMICS
  • 1993-06. A chromosome region-specific mapping strategy reveals gene-rich telomeric ends in wheat in CHROMOSOMA
  • 1994. Inactivation of Repeated Genes — DNA-DNA Interaction? in HOMOLOGOUS RECOMBINATION AND GENE SILENCING IN PLANTS
  • 1994-03. Gene inactivation triggered by recognition between DNA repeats in CELLULAR AND MOLECULAR LIFE SCIENCES
  • 1988-05. Analysis of the T-DNA structure in a large number of transgenic petunias generated by Agrobacterium-mediated transformation in PLANT MOLECULAR BIOLOGY
  • 1993-09. Epigenetic repeat-induced gene silencing (RIGS) inArabidopsis in PLANT MOLECULAR BIOLOGY
  • Journal

    TITLE

    Molecular Genetics and Genomics

    ISSUE

    3

    VOLUME

    244

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/bf00285449

    DOI

    http://dx.doi.org/10.1007/bf00285449

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1015099723

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/8058033


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